Adams, T. E., Alpert, S., & Hanahan, D. (1987). Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature, 325(6101), 223–228. https://doi.org/10.1038/325223a0

CAS  Article  PubMed  Google Scholar 

Affo, S., Yu, L. X., & Schwabe, R. F. (2017). The role of cancer-associated fibroblasts and fibrosis in liver cancer. Annual Review of Pathology: Mechanisms of Disease, 12, 153–186. https://doi.org/10.1146/annurev-pathol-052016-100322

CAS  Article  Google Scholar 

Amit, M., Takahashi, H., Dragomir, M. P., Lindemann, A., Gleber-Netto, F. O., Pickering, C. R., Anfossi, S., Osman, A. A., Cai, Y., Wang, R., Knutsen, E., Shimizu, M., Ivan, C., Rao, X., Wang, J., Silverman, D. A., Tam, S., Zhao, M., Caulin, C., . . . Myers, J. N. (2020). Loss of p53 drives neuron reprogramming in head and neck cancer. Nature, 578(7795), 449-454. https://doi.org/10.1038/s41586-020-1996-3

Anderson, R. L., Balasas, T., Callaghan, J., Coombes, R. C., Evans, J., Hall, J. A., Kinrade, S., Jones, D., Jones, P. S., Jones, R., Marshall, J. F., Panico, M. B., Shaw, J. A., Steeg, P. S., Sullivan, M., Tong, W., Westwell, A. D., Ritchie, J. W. A., Cancer Research UK & Cancer Therapeutics CRCA.MWG . (2019). A framework for the development of effective anti-metastatic agents. Nat Rev Clin Oncol, 16(3), 185–204. https://doi.org/10.1038/s41571-018-0134-8

Article  PubMed  Google Scholar 

Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019). From NASH to HCC: Current concepts and future challenges. Nature Reviews. Gastroenterology & Hepatology, 16(7), 411–428. https://doi.org/10.1038/s41575-019-0145-7

Article  Google Scholar 

Arch, J. R., Ainsworth, A. T., Cawthorne, M. A., Piercy, V., Sennitt, M. V., Thody, V. E., Wilson, C., & Wilson, S. (1984). Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature, 309(5964), 163–165. https://doi.org/10.1038/309163a0

CAS  Article  PubMed  Google Scholar 

Aryal, B., Singh, A. K., Zhang, X., Varela, L., Rotllan, N., Goedeke, L., Chaube, B., Camporez, J. P., Vatner, D. F., Horvath, T. L., Shulman, G. I., Suárez, Y., & Fernández-Hernando, C. (2018). Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. JCI Insight, 3(6). https://doi.org/10.1172/jci.insight.97918

Aucejo, F., Kim, R., Zein, N., Quintini, C., Uso, T. D., Lopez, R., Eghtesad, B., Fung, J., Miller, C., & Yerian, L. (2009). Vascular endothelial growth factor receptor 2 expression in non-tumorous cirrhotic liver is higher when hepatoma is beyond Milan criteria. Liver Transplantation, 15(2), 169–176. https://doi.org/10.1002/lt.21678

Article  PubMed  Google Scholar 

Avgerinos, K. I., Spyrou, N., Mantzoros, C. S., & Dalamaga, M. (2019). Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism, 92, 121–135. https://doi.org/10.1016/j.metabol.2018.11.001

CAS  Article  PubMed  Google Scholar 

Azzi, S., Hebda, J. K., & Gavard, J. (2013). Vascular permeability and drug delivery in cancers. Frontiers in Oncology, 3, 211. https://doi.org/10.3389/fonc.2013.00211

Article  PubMed  PubMed Central  Google Scholar 

Babol, K., Przybylowska, K., Lukaszek, M., Pertynski, T., & Blasiak, J. (2004). An association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene and endometrial cancer and obesity. Journal of Experimental & Clinical Cancer Research, 23(4), 669–674.

CAS  Google Scholar 

Bäckhed, F., Crawford, P. A., O’Donnell, D., & Gordon, J. I. (2007). Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor. Proceedings of the National Academy of Sciences of the United States of America, 104(2), 606–611. https://doi.org/10.1073/pnas.0605957104

CAS  Article  PubMed  PubMed Central  Google Scholar 

Baeriswyl, V., & Christofori, G. (2009). The angiogenic switch in carcinogenesis. Seminars in Cancer Biology, 19(5), 329–337. https://doi.org/10.1016/j.semcancer.2009.05.003

CAS  Article  PubMed  Google Scholar 

Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A. M., Gingras, M. C., Miller, D. K., Christ, A. N., Bruxner, T. J., Quinn, M. C., Nourse, C., Murtaugh, L. C., Harliwong, I., Idrisoglu, S., Manning, S., Nourbakhsh, E., Wani, S., Fink, L., Holmes, O., . . . Grimmond, S. M. (2016). Genomic analyses identify molecular subtypes of pancreatic cancer. Nature, 531(7592), 47-52. https://doi.org/10.1038/nature16965

Barbieri, A., Bimonte, S., Palma, G., Luciano, A., Rea, D., Giudice, A., Scognamiglio, G., La Mantia, E., Franco, R., Perdonà, S., De Cobelli, O., Ferro, M., Zappavigna, S., Stiuso, P., Caraglia, M., & Arra, C. (2015). The stress hormone norepinephrine increases migration of prostate cancer cells in vitro and in vivo. International Journal of Oncology, 47(2), 527–534. https://doi.org/10.3892/ijo.2015.3038

CAS  Article  PubMed  Google Scholar 

Barron, T. I., Connolly, R. M., Sharp, L., Bennett, K., & Visvanathan, K. (2011). Beta blockers and breast cancer mortality: A population-based study. Journal of Clinical Oncology, 29(19), 2635–2644. https://doi.org/10.1200/jco.2010.33.5422

CAS  Article  PubMed  Google Scholar 

Batalla-Covello, J., Ali, S., Xie, T., & Amit, M. (2022). β-Adrenergic signaling in skin cancer. FASEB BioAdvances, 4(4), 225–234. https://doi.org/10.1096/fba.2021-00097

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bergamaschi, A., Tagliabue, E., Sorlie, T., Naume, B., Triulzi, T., Orlandi, R., Russnes, H. G., Nesland, J. M., Tammi, R., Auvinen, P., Kosma, V. M., Menard, S., & Borresen-Dale, A. L. (2008). Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome. The Journal of Pathology, 214(3), 357–367. https://doi.org/10.1002/path.2278

CAS  Article  PubMed  Google Scholar 

Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., & Hanahan, D. (2000). Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biology, 2(10), 737–744. https://doi.org/10.1038/35036374

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bergmann, L., Maute, L., Heil, G., Rüssel, J., Weidmann, E., Köberle, D., Fuxius, S., Weigang-Köhler, K., Aulitzky, W. E., Wörmann, B., Hartung, G., Moritz, B., Edler, L., Burkholder, I., Scheulen, M. E., & Richly, H. (2015). A prospective randomised phase-II trial with gemcitabine versus gemcitabine plus sunitinib in advanced pancreatic cancer: A study of the CESAR Central European Society for Anticancer Drug Research-EWIV. European Journal of Cancer, 51(1), 27–36. https://doi.org/10.1016/j.ejca.2014.10.010

CAS  Article  PubMed  Google Scholar 

Bergö, M., Olivecrona, G., & Olivecrona, T. (1996). Forms of lipoprotein lipase in rat tissues: in adipose tissue the proportion of inactive lipase increases on fasting. Biochemical Journal, 313(Pt 3), 893–898. https://doi.org/10.1042/bj3130893

Article  PubMed  PubMed Central  Google Scholar 

Berriel Diaz, M., Herzig, S., & Schafmeier, T. (2016). Biological mechanisms for the effect of obesity on cancer risk: Experimental evidence. Recent Results in Cancer Research, 208, 219–242. https://doi.org/10.1007/978-3-319-42542-9_12

CAS  Article  PubMed  Google Scholar 

Bhaskaran, K., Douglas, I., Forbes, H., & dos-Santos-Silva, I., Leon, D. A., & Smeeth, L. (2014). Body-mass index and risk of 22 specific cancers: A population-based cohort study of 5·24 million UK adults. Lancet, 384(9945), 755–765. https://doi.org/10.1016/s0140-6736(14)60892-8

Article  PubMed  PubMed Central  Google Scholar 

Blackwell, K. L., Haroon, Z. A., Shan, S., Saito, W., Broadwater, G., Greenberg, C. S., & Dewhirst, M. W. (2000). Tamoxifen inhibits angiogenesis in estrogen receptor-negative animal models. Clinical Cancer Research, 6(11), 4359–4364.

CAS  PubMed  Google Scholar 

Blücher, C., Iberl, S., Schwagarus, N., Müller, S., Liebisch, G., Höring, M., Hidrobo, M. S., Ecker, J., Spindler, N., Dietrich, A., Burkhardt, R., & Stadler, S. C. (2020). Secreted factors from adipose tissue reprogram tumor lipid metabolism and induce motility by modulating PPARα/ANGPTL4 and FAK. Molecular Cancer Research, 18(12), 1849–1862. https://doi.org/10.1158/1541-7786.Mcr-19-1223

Article  PubMed  Google Scholar 

Bos, P. D., Zhang, X. H., Nadal, C., Shu, W., Gomis, R. R., Nguyen, D. X., Minn, A. J., van de Vijver, M. J., Gerald, W. L., Foekens, J. A., & Massagué, J. (2009). Genes that mediate breast cancer metastasis to the brain. Nature, 459(7249), 1005–1009. https://doi.org/10.1038/nature08021

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492

Article  Google Scholar 

Bu, D., Crewe, C., Kusminski, C. M., Gordillo, R., Ghaben, A. L., Kim, M., Park, J., Deng, H., Xiong, W., Liu, X. Z., Lonning, P. E., Halberg, N., Rios, A., Chang, Y., Gonzalez, A., Zhang, N., An, Z., & Scherer, P. E. (2019). Human endotrophin as a driver of malignant tumor growth. JCI Insight, 5. https://doi.org/10.1172/jci.insight.125094

Caldwell, S. H., Crespo, D. M., Kang, H. S., & Al-Osaimi, A. M. (2004). Obesity and hepatocellular carcinoma. Gastroenterology, 127(5 Suppl 1), S97-103. https://doi.org/10.1053/j.gastro.2004.09.021

CAS  Article  PubMed  Google Scholar 

Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. The New England Journal of Medicine, 348(17), 1625–1638. https://doi.org/10.1056/NEJMoa021423

Article  PubMed  Google Scholar 

Camell, C. D., Sander, J., Spadaro, O., Lee, A., Nguyen, K. Y., Wing, A., Goldberg, E. L., Youm, Y. H., Brown, C. W., Elsworth, J., Rodeheffer, M. S., Schultze, J. L., & Dixit, V. D. (2017). Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature, 550(7674), 119–123. https://doi.org/10.1038/nature24022

CAS  Article  PubMed  PubMed Central  Google Scholar 

Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J. L., Bouloumié, A., Barbatelli, G., Cinti, S., Svensson, P. A., Barsh, G. S., Zucker, J. D., Basdevant, A., Langin, D., & Clément, K. (2005). Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes, 54(8), 2277–2286. https://doi.org/10.2337/diabetes.54.8.2277

CAS  Article  PubMed  Google Scholar 

Cao, D. X., Wu, G. H., Yang, Z. A., Zhang, B., Jiang, Y., Han, Y. S., He, G. D., Zhuang, Q. L., Wang, Y. F., Huang, Z. L., & Xi, Q. L. (2010). Role of beta1-adrenoceptor in increased lipolysis in cancer cachexia. Cancer Science, 101(7), 1639–1645. https://doi.org/10.1111/j.1349-7006.2010.01582.x

CAS  Article  PubMed  Google Scholar 

Cao, Y. (2010). Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases. Nature Reviews. Drug Discovery, 9(2), 107–115. https://doi.org/10.1038/nrd3055

CAS  Article  PubMed  Google Scholar 

Cao, Y. (2013). Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity. Cell Metabolism, 18(4), 478–489. https://doi.org/10.1016/j.cmet.2013.08.008

CAS  Article  PubMed  Google Scholar 

Chakravarthy, A., Khan, L., Bensler, N. P., Bose, P., & De Carvalho, D. D. (2018). TGF-beta-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure. Nature Communications, 9(1), 4692. https://doi.org/10.1038/s41467-018-06654-8

CAS  Article  PubMed