Nussbaum ES. Vascular malformations of the brain. Minn Med. 2013;96(5):40–3.

PubMed  Google Scholar 

Whitehead KJ, Smith MC, Li DY. Arteriovenous malformations and other vascular malformation syndromes. Cold Spring Harb Perspect Med. 2013;3(2):a006635.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Florian IA, Beni L, Moisoiu V, Timis TL, Florian IS, Balașa A, et al. ‘De novo’ brain AVMs-hypotheses for development and a systematic review of reported cases. Medicina (Kaunas). 2021;57(3).

Komiyama M. Pathogenesis of brain arteriovenous malformations. Neurol Med Chir (Tokyo). 2016;56(6):317–25.

Article  Google Scholar 

Sturiale CL, Puca A, Sebastiani P, Gatto I, Albanese A, Di Rocco C, et al. Single nucleotide polymorphisms associated with sporadic brain arteriovenous malformations: where do we stand? Brain. 2013;136(Pt 2):665–81.

PubMed  Article  Google Scholar 

Ustaszewski A, Janowska-Głowacka J, Wołyńska K, Pietrzak A, Badura-Stronka M. Genetic syndromes with vascular malformations - update on molecular background and diagnostics. Arch Med Sci. 2021;17(4):965–91.

CAS  PubMed  Article  Google Scholar 

Ozpinar A, Mendez G, Abla AA. Epidemiology, genetics, pathophysiology, and prognostic classifications of cerebral arteriovenous malformations. Handb Clin Neurol. 2017;143:5–13.

PubMed  Article  Google Scholar 

Hashimoto T, Lam T, Boudreau NJ, Bollen AW, Lawton MT, Young WL. Abnormal balance in the angiopoietin-tie2 system in human brain arteriovenous malformations. Circ Res. 2001;89(2):111–3.

CAS  PubMed  Article  Google Scholar 

Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL. Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir Suppl. 2011;111:83–92.

PubMed  PubMed Central  Article  Google Scholar 

• Chen CJ, Ding D, Derdeyn CP, Lanzino G, Friedlander RM, Southerland AM, et al. Brain arteriovenous malformations: a review of natural history, pathobiology, and interventions. Neurology. 2020;95(20):917–27. This reference is a great review detailing the pathophysiology of AVMs, as well as updated numbers on the natural history of this vascular malformation.

Al-Shahi R, Bhattacharya JJ, Currie DG, Papanastassiou V, Ritchie V, Roberts RC, et al. Prospective, population-based detection of intracranial vascular malformations in adults: the Scottish Intracranial Vascular Malformation Study (SIVMS). Stroke. 2003;34(5):1163–9.

PubMed  Article  Google Scholar 

Stapf C, Mast H, Sciacca RR, Berenstein A, Nelson PK, Gobin YP, et al. The New York Islands AVM Study: design, study progress, and initial results. Stroke. 2003;34(5):e29-33.

CAS  PubMed  Article  Google Scholar 

Brown RD Jr, Wiebers DO, Forbes G, O’Fallon WM, Piepgras DG, Marsh WR, et al. The natural history of unruptured intracranial arteriovenous malformations. J Neurosurg. 1988;68(3):352–7.

PubMed  Article  Google Scholar 

da Costa L, Wallace MC, Ter Brugge KG, O’Kelly C, Willinsky RA, Tymianski M. The natural history and predictive features of hemorrhage from brain arteriovenous malformations. Stroke. 2009;40(1):100–5.

PubMed  Article  Google Scholar 

Halim AX, Johnston SC, Singh V, McCulloch CE, Bennett JP, Achrol AS, et al. Longitudinal risk of intracranial hemorrhage in patients with arteriovenous malformation of the brain within a defined population. Stroke. 2004;35(7):1697–702.

PubMed  Article  Google Scholar 

Hernesniemi JA, Dashti R, Juvela S, Väärt K, Niemelä M, Laakso A. Natural history of brain arteriovenous malformations: a long-term follow-up study of risk of hemorrhage in 238 patients. Neurosurgery. 2008;63(5):823–9; discussion 9–31.

Itoyama Y, Uemura S, Ushio Y, Kuratsu J, Nonaka N, Wada H, et al. Natural course of unoperated intracranial arteriovenous malformations: study of 50 cases. J Neurosurg. 1989;71(6):805–9.

CAS  PubMed  Article  Google Scholar 

Kim H, Sidney S, McCulloch CE, Poon KY, Singh V, Johnston SC, et al. Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients. Stroke. 2007;38(9):2430–7.

PubMed  Article  Google Scholar 

Stapf C, Mast H, Sciacca RR, Choi JH, Khaw AV, Connolly ES, et al. Predictors of hemorrhage in patients with untreated brain arteriovenous malformation. Neurology. 2006;66(9):1350–5.

CAS  PubMed  Article  Google Scholar 

Wedderburn CJ, van Beijnum J, Bhattacharya JJ, Counsell CE, Papanastassiou V, Ritchie V, et al. Outcome after interventional or conservative management of unruptured brain arteriovenous malformations: a prospective, population-based cohort study. Lancet Neurol. 2008;7(3):223–30.

PubMed  Article  Google Scholar 

Yamada S, Takagi Y, Nozaki K, Kikuta K, Hashimoto N. Risk factors for subsequent hemorrhage in patients with cerebral arteriovenous malformations. J Neurosurg. 2007;107(5):965–72.

PubMed  Article  Google Scholar 

Gross BA, Du R. Natural history of cerebral arteriovenous malformations: a meta-analysis. J Neurosurg. 2013;118(2):437–43.

PubMed  Article  Google Scholar 

Wilkins RH. Natural history of intracranial vascular malformations: a review. Neurosurgery. 1985;16(3):421–30.

CAS  PubMed  Article  Google Scholar 

Laakso A, Hernesniemi J. Arteriovenous malformations: epidemiology and clinical presentation. Neurosurg Clin N Am. 2012;23(1):1–6.

PubMed  Article  Google Scholar 

Rutledge WC, Ko NU, Lawton MT, Kim H. Hemorrhage rates and risk factors in the natural history course of brain arteriovenous malformations. Transl Stroke Res. 2014;5(5):538–42.

PubMed  PubMed Central  Article  Google Scholar 

Duong DH, Young WL, Vang MC, Sciacca RR, Mast H, Koennecke HC, et al. Feeding artery pressure and venous drainage pattern are primary determinants of hemorrhage from cerebral arteriovenous malformations. Stroke. 1998;29(6):1167–76.

CAS  PubMed  Article  Google Scholar 

Langer DJ, Lasner TM, Hurst RW, Flamm ES, Zager EL, King JT, Jr. Hypertension, small size, and deep venous drainage are associated with risk of hemorrhagic presentation of cerebral arteriovenous malformations. Neurosurgery 1998;42(3):481–6; discussion 7–9.

Spetzler RF, Hargraves RW, McCormick PW, Zabramski JM, Flom RA, Zimmerman RS. Relationship of perfusion pressure and size to risk of hemorrhage from arteriovenous malformations. J Neurosurg. 1992;76(6):918–23.

CAS  PubMed  Article  Google Scholar 

Mast H, Mohr JP, Osipov A, Pile-Spellman J, Marshall RS, Lazar RM, et al. ‘Steal’ is an unestablished mechanism for the clinical presentation of cerebral arteriovenous malformations. Stroke. 1995;26(7):1215–20.

CAS  PubMed  Article  Google Scholar 

• Spetzler RF, Martin NA. A proposed grading system for arteriovenous malformations. J Neurosurg. 1986;65(4):476–83. Although not from the past 3 years, this is a landmark study that introduced us to the Spetzler-Martin grading system that we use to this day.

Davidson AS, Morgan MK. How safe is arteriovenous malformation surgery? A prospective, observational study of surgery as first-line treatment for brain arteriovenous malformations. Neurosurgery. 2010;66(3):498–504; discussion -5.

Hamilton MG, Spetzler RF. The prospective application of a grading system for arteriovenous malformations. Neurosurgery. 1994;34(1):2–6; discussion -7.

Han PP, Ponce FA, Spetzler RF. Intention-to-treat analysis of Spetzler-Martin grades IV and V arteriovenous malformations: natural history and treatment paradigm. J Neurosurg. 2003;98(1):3–7.

PubMed  Article  Google Scholar 

Spetzler RF, Ponce FA. A 3-tier classification of cerebral arteriovenous malformations. Clinical article J Neurosurg. 2011;114(3):842–9.

PubMed  Article  Google Scholar 

Kim H, Abla AA, Nelson J, McCulloch CE, Bervini D, Morgan MK, et al. Validation of the supplemented Spetzler-Martin grading system for brain arteriovenous malformations in a multicenter cohort of 1009 surgical patients. Neurosurgery. 2015;76(1):25–31; discussion -2; quiz 2–3.

Kim H, Pourmohamad T, Westbroek EM, McCulloch CE, Lawton MT, Young WL. Evaluating performance of the spetzler-martin supplemented model in selecting patients with brain arteriovenous malformation for surgery. Stroke. 2012;43(9):2497–9.

PubMed  PubMed Central  Article  Google Scholar 

Lawton MT, Kim H, McCulloch CE, Mikhak B, Young WL. A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery. Neurosurgery. 2010;66(4):702–13; discussion 13.

Mohr JP, Parides MK, Stapf C, Moquete E, Moy CS, Overbey JR, et al. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet. 2014;383(9917):614–21.

CAS  PubMed  Article  Google Scholar 

• Feghali J, Huang J. Updates in arteriovenous malformation management: the post-ARUBA era. Stroke and Vascular Neurology. 2020;5(1):34–9. This is an important study, as it sheds light on the many limitations of the ARUBA trial, which falsely recommended observation rather than treatment of AVMs.

Lang M, Moore NZ, Rasmussen PA, Bain MD. Treatment outcomes of a randomized trial of unruptured brain arteriovenous malformation-eligible unruptured brain arteriovenous malformation patients. Neurosurgery. 2018;83(3):548–55.

PubMed  Article  Google Scholar 

Magro E, Gentric JC, Darsaut TE, Ziegler D, Msi, Bojanowski MW, et al. Responses to ARUBA: a systematic review and critical analysis for the design of future arteriovenous malformation trials. J Neurosurg. 2017;126(2):486–94.

Knopman J, Stieg PE. Management of unruptured brain arteriovenous malformations. Lancet. 2014;383(9917):581–3.

PubMed  Article  Google Scholar 

Lawton MT. The role of AVM microsurgery in the aftermath of a randomized trial of unruptured brain arteriovenous malformations. Am J Neuroradiol. 2015;36(4):617–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Potts MB, Lau D, Abla AA, Kim H, Young WL, Lawton MT. Current surgical results with low-grade brain arteriovenous malformations. J Neurosurg. 2015;122(4):912–20.

PubMed  PubMed Central  Article  Google Scholar 

Mosimann PJ, Chapot R. Contemporary endovascular techniques for the curative treatment of cerebral arteriovenous malformations and review of neurointerventional outcomes. J Neurosurg Sci. 2018;62(4):505–13.

PubMed  Article  Google Scholar 

• Wu EM, El Ahmadieh TY, McDougall CM, Aoun SG, Mehta N, Neeley OJ, et al. Embolization of brain arteriovenous malformations with intent to cure: a systematic review. J Neurosurg. 2019;132(2):388–99. This study shows how neurovascular interventionalists started looking at endovascular embolization as a potential cure to AVMs, not just as an adjunct to another treatment modality.

Ren Q, He M, Zeng Y, Liu Z, Liu H, Xu J. Microsurgery for intracranial arteriovenous malformation: Long-term outcomes in 445 patients. PLoS ONE. 2017;12(3): e0174325.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Stapf C, Mohr JP, Choi JH, Hartmann A, Mast H. Invasive treatment of unruptured brain arteriovenous malformations is experimental therapy. Curr Opin Neurol. 2006;19(1):63–8.

PubMed  Article  Google Scholar 

Starke RM, Komotar RJ, Hwang BY, Fischer LE, Garrett MC, Otten ML, et al. Treatment guidelines for cerebral arteriovenous malformation microsurgery. Br J Neurosurg. 2009;23(4):376–86.

PubMed