Amylin regulates testosterone levels via steroidogenesis-related enzymes in the central nervous system of male mice

Keywords

Amylin

Steroidogenesis-related enzymes

3β-hydroxysteroid dehydrogenase

Cytochrome P450 17A1

Steroidogenic acute regulatory protein

Phospho-extracellular signal-regulated kinase

Abbreviations3β-HSD

3β-hydroxysteroid dehydrogenase

CNS

Central nervous system

CYP17A1

Cytochrome P450 17A1

DHEA

Dehydroepiandrosterone

DMH

Dorsomedial nucleus of the hypothalamus

ELISA

Enzyme-linked immunosorbent assay

ERK

Extracellular signal-regulated kinase

GABA

Gamma aminobutyric acid

GAPDH

Glyceraldehyde-3-phosphate dehydrogenase

GnRH

Gonadotropin-releasing hormone

GRN

Gigantocellular reticular nucleus

HPA

Hypothalamic-pituitary-adrenal axis

HPG

Hypothalamic-pituitary-gonadal axis

IACUC

Institutional Animal Care and Use Committee

LDT

Lateral dorsal tegmental nucleus

LHA

Lateral hypothalamic area

MAPK

Mitogen-activated protein kinase family

MARN

Magnocellular reticular nucleus

NTS

Nucleus tractus solitarii

PCRt

Parvocellular reticular nucleus

pERK

phospho-Extracellular signal-regulated kinase

PVN

Paraventricular nucleus

PVT

Paraventricular nucleus of the thalamus

RPa

Raphe pallidus nucleus

RSCg

Granular retrosplenial cortex

S1

Primary somatosensory cortex, barrel field

S2

Secondary somatosensory cortex

SAC

Secondary auditory cortex

SOC

Superior olivary complex

StAR

Steroidogenic acute regulatory protein

STN

Spinal trigeminal nucleus, oral part

TMN

Trigeminal motor nucleus

VMH

Ventromedial hypothalamic nucleus

VTA

Ventral tegmental area

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