Ahluwalia B, Moraes L, Magnusson MK, Öhman L (2018) Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies. Scand J Gastroenterol 53(4):379–389

PubMed  Article  Google Scholar 

Ananthakrishnan AN (2015) Epidemiology and risk factors for IBD. Nat Rev Gastroenterol Hepatol 12(4):205–217

PubMed  Article  Google Scholar 

Asensi V, Valle E, Meana A, Fierer J, Celada A, Alvarez V, Paz J, Coto E, Carton JA, Maradona JA (2004) In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis. Infect Immun 72(7):3823–3828

CAS  PubMed  PubMed Central  Article  Google Scholar 

Atreya R, Mudter J, Finotto S, Müllberg J, Jostock T, Wirtz S, Schütz M, Bartsch B, Holtmann M, Becker C (2000) Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 6(5):583–588

CAS  PubMed  Article  Google Scholar 

Atreya R, Neurath M (2008) New therapeutic strategies for treatment of inflammatory bowel disease. Mucosal Immunol 1(3):175–182

CAS  PubMed  Article  Google Scholar 

Barnes TC, Anderson ME, Moots RJ (2011) The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis. Int J Rheumatol. https://doi.org/10.1155/2011/721608

Article  PubMed  PubMed Central  Google Scholar 

Becker C, Dornhoff H, Neufert C, Fantini MC, Wirtz S, Huebner S, Nikolaev A, Lehr H-A, Murphy AJ, Valenzuela DM (2006) Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J Immunol 177(5):2760–2764

CAS  PubMed  Article  Google Scholar 

Beltrán CJ, Núñez LE, Díaz-Jiménez D, Farfan N, Candia E, Heine C, López F, González MJ, Quera R, Hermoso MA (2010) Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease. Inflamm Bowel Dis 16(7):1097–1107

PubMed  Article  Google Scholar 

Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441(7090):235–238

CAS  PubMed  Article  Google Scholar 

Boe A, Baiocchi M, Carbonatto M, Papoian R, Serlupi-Crescenzi O (1999) Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis. Cytokine 11(12):1057–1064

CAS  PubMed  Article  Google Scholar 

Borghini R, Vescovo M, Giordano C, Donato G, Picarelli A (2021) Onset of suspected ulcerative colitis after treatment with tocilizumab in patient with celiac disease and juvenile idiopathic arthritis. Inflamm Bowel Dis 27(6):e76–e78

PubMed  Article  Google Scholar 

Bouguen G, Chevaux J-B, Peyrin-Biroulet L (2011) Recent advances in cytokines: therapeutic implications for inflammatory bowel diseases. World J Gastroenterol: WJG 17(5):547

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bradham C, McClay DR (2006) p38 MAPK in development and cancer. Cell Cycle 5(8):824–828

CAS  PubMed  Article  Google Scholar 

Bray SJ (2006) Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7(9):678–689

CAS  PubMed  Article  Google Scholar 

Brzozowski B, Mazur-Bialy A, Pajdo R, Kwiecien S, Bilski J, Zwolinska-Wcislo M, Mach T, Brzozowski T (2016) Mechanisms by which stress affects the experimental and clinical inflammatory bowel disease (IBD): role of brain-gut axis. Curr Neuropharmacol 14(8):892–900

CAS  PubMed  PubMed Central  Article  Google Scholar 

Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ, Powrie F (2010) Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464(7293):1371–1375

CAS  PubMed  PubMed Central  Article  Google Scholar 

Cai J, Zhang N, Zheng Y, De Wilde RF, Maitra A, Pan D (2010) The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev 24(21):2383–2388

CAS  PubMed  PubMed Central  Article  Google Scholar 

Caiello I, Minnone G, Holzinger D, Vogl T, Prencipe G, Manzo A, De Benedetti F, Strippoli R (2014) IL-6 amplifies TLR mediated cytokine and chemokine production: implications for the pathogenesis of rheumatic inflammatory diseases. PLoS ONE 9(10):e107886

PubMed  PubMed Central  Article  CAS  Google Scholar 

Calabrese LH, Rose-John S (2014) IL-6 biology: implications for clinical targeting in rheumatic disease. Nat Rev Rheumatol 10(12):720–727

CAS  PubMed  Article  Google Scholar 

Cao J, Zhang H, Yang Z, Zhao J, Ma H (2020) Effect of dehydroepiandrosterone on the immune response and gut microbiota in dextran sulfate sodium-induced colitis mice. Mol Immunol 118:60–72

CAS  PubMed  Article  Google Scholar 

Cao Q, Lin Y, Yue C, Wang Y, Quan F, Cui X, Bi R, Tang X, Yang Y, Wang C (2021) IL-6 deficiency promotes colitis by recruiting Ly6Chi monocytes into inflamed colon tissues in a CCL2-CCR2-dependent manner. Eur J Pharmacol 904:174165

CAS  PubMed  Article  Google Scholar 

Chen W, Yuan H, Cao W, Wang T, Chen W, Yu H, Fu Y, Jiang B, Zhou H, Guo H (2019) Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation. Theranostics 9(14):3980

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chen Y, Chen H, Ding J, Stanton C, Ross RP, Zhao J, Zhang H, Yang B, Chen W (2021) Bifidobacterium longum ameliorates dextran sulfate sodium-induced colitis by producing conjugated linoleic acid, protecting intestinal mechanical barrier, restoring unbalanced gut Microbiota, and regulating the toll-like receptor-4/Nuclear Factor-κB signaling pathway. J Agric Food Chem 69(48):14593–14608

CAS  PubMed  Article  Google Scholar 

Choi JS, Kim K-H, Lau LF (2015) The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6. Mucosal Immunol 8(6):1285–1296

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chonov DC, Ignatova MMK, Ananiev JR, Gulubova MV (2019) IL-6 activities in the tumour microenvironment. Part 1. Open Access Macedonian J Med Sci 7(14):2391

Article  Google Scholar 

Clarke WT, Feuerstein JD (2019) Colorectal cancer surveillance in inflammatory bowel disease: practice guidelines and recent developments. World J Gastroenterol 25(30):4148

PubMed  PubMed Central  Article  Google Scholar 

Coskun M, Vermeire S, Nielsen OH (2017) Novel targeted therapies for inflammatory bowel disease. Trends Pharmacol Sci 38(2):127–142

CAS  PubMed  Article  Google Scholar 

Dai Y, Jiao H, Teng G, Wang W, Zhang R, Wang Y, Hebbard L, George J, Qiao L (2014) Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling. Mol Cancer Ther 13(5):1206–1216

CAS  PubMed  Article  Google Scholar 

Danese S, Vermeire S, Hellstern P, Panaccione R, Rogler G, Fraser G, Kohn A, Desreumaux P, Leong RW, Comer GM (2019) Randomised trial and open-label extension study of an anti-interleukin-6 antibody in Crohn’s disease (ANDANTE I and II). Gut 68(1):40–48

CAS  PubMed  Article  Google Scholar 

De Souza HS, Fiocchi C (2016) Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol 13(1):13–27

PubMed  Article  CAS  Google Scholar 

Deiana M, Serra G, Corona G (2018) Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds. Food Funct 9(8):4085–4099

CAS  PubMed  Article  Google Scholar 

Deng J, Zhao L, Yuan X, Li Y, Shi J, Zhang H, Zhao Y, Han L, Wang H, Yan Y (2022) Pre-administration of berberine exerts chemopreventive effects in aom/dss-induced colitis-associated carcinogenesis mice via modulating inflammation and intestinal microbiota. Nutrients 14(4):726

CAS  PubMed  PubMed Central  Article  Google Scholar 

Devaraj S, Hemarajata P, Versalovic J (2013) The human gut microbiome and body metabolism: implications for obesity and diabetes. Clin Chem 59(4):617–628

CAS  PubMed  PubMed Central  Article  Google Scholar 

Diehl SA, Schmidlin H, Nagasawa M, Blom B, Spits H (2012) IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells. Immunol Cell Biol 90(8):802–811

CAS  PubMed  PubMed Central  Article  Google Scholar 

Dimitrov S, Lange T, Benedict C, Nowell MA, Jones SA, Scheller J, Rose-John S, Born J, Dimitrov S, Lange T (2006) Sleep enhances IL-6 trans-signaling in humans. FASEB J 20(12):2174–2176

CAS  PubMed  Article  Google Scholar 

Dinarello CA (1999) IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol 103(1):11–24

CAS  PubMed  Article  Google Scholar 

Dinarello CA (2009) Interleukin-1β and the autoinflammatory diseases. Mass Medical Soc 360:2467–2470