Disclosures: The Department of Cardiology, Heart Lung Center, Leiden University Medical Centre received research grants from Alnylam, Abbott Vascular, Bayer, Biotronik, Bioventrix, Boston Scientific, Edwards Lifesciences, GE Healthcare, Ionis and Medtronic. JJB received speaker fees from Abbott Vascular. NAM received speaker fees from Abbott Vascular and GE Healthcare and has been in the Medical Advisory Board of Philips Ultrasound. VD received speaker fees from Abbott Vascular, Edwards Lifesciences, GE Healthcare, Medtronic, MSD and Novartis. JS received speaker fees from Pfizer. PD received speaker fees from Pfizer and has been involved in the Pfizer Medical Advisory Board. The remaining authors have nothing to disclose.