Immunoglobulin G N-glycan, inflammation and type 2 diabetes in East Asian and European populations: a Mendelian randomization study

Ackerman ME, Crispin M, Yu X, Baruah K, Boesch AW, Harvey DJ, et al. Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity. J Clin Invest. 2013;123(5):2183–92. https://doi.org/10.1172/jci65708.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–25. https://doi.org/10.1093/ije/dyv080.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–14. https://doi.org/10.1002/gepi.21965.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Hemani G, Davey SG. Invited commentary: detecting individual and global horizontal pleiotropy in Mendelian randomization—a job for the humble heterogeneity statistic? Am J Epidemiol. 2018;187(12):2681–5. https://doi.org/10.1093/aje/kwy185.

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Thompson SG. Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol. 2017;32(5):377–89. https://doi.org/10.1007/s10654-017-0255-x.

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37(7):658–65. https://doi.org/10.1002/gepi.21758.

Article  PubMed  PubMed Central  Google Scholar 

Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes. Lancet. 2017;389(10085):2239–51. https://doi.org/10.1016/s0140-6736(17)30058-2.

CAS  Article  PubMed  Google Scholar 

Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives. Nat Rev Endocrinol. 2011;8(4):228–36. https://doi.org/10.1038/nrendo.2011.183.

CAS  Article  PubMed  Google Scholar 

Dalmon J, Laurent M, Courtois G. The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element. Mol Cell Biol. 1993;13(2):1183–93. https://doi.org/10.1128/mcb.13.2.1183-1193.1993.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Dong SS, Zhang K, Guo Y, Ding JM, Rong Y, Feng JC, et al. Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study. Genome Med. 2021;13(1):48. https://doi.org/10.1186/s13073-021-00865-3.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Dotz V, Lemmers RFH, Reiding KR, Hipgrave Ederveen AL, Lieverse AG, Mulder MT, et al. Plasma protein N-glycan signatures of type 2 diabetes. Biochim Biophys Acta Gen Subj. 2018;1862(12):2613–22. https://doi.org/10.1016/j.bbagen.2018.08.005.

CAS  Article  PubMed  Google Scholar 

Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA. 2017;318(19):1925–6. https://doi.org/10.1001/jama.2017.17219.

Article  PubMed  Google Scholar 

Ercan A, Cui J, Chatterton DE, Deane KD, Hazen MM, Brintnell W, et al. Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis Rheum. 2010;62(8):2239–48. https://doi.org/10.1002/art.27533.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gebrehiwot AG, Melka DS, Kassaye YM, Rehan IF, Rangappa S, Hinou H, et al. Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers. PLoS ONE. 2018;13(12): e0209515. https://doi.org/10.1371/journal.pone.0209515.

Article  PubMed  PubMed Central  Google Scholar 

Greto VL, Cvetko A, Štambuk T, Dempster NJ, Kifer D, Deriš H, et al. Extensive weight loss reduces glycan age by altering IgG N-glycosylation. Int J Obes (lond). 2021;45(7):1521–31. https://doi.org/10.1038/s41366-021-00816-3.

CAS  Article  Google Scholar 

Itoh N, Sakaue S, Nakagawa H, Kurogochi M, Ohira H, Deguchi K, et al. Analysis of N-glycan in serum glycoproteins from db/db mice and humans with type 2 diabetes. Am J Physiol Endocrinol Metab. 2007;293(4):E1069-1077. https://doi.org/10.1152/ajpendo.00182.2007.

CAS  Article  PubMed  Google Scholar 

Jin R, Liu L, Zhang S, Nanda A, Li G. Role of inflammation and its mediators in acute ischemic stroke. J Cardiovasc Transl Res. 2013;6(5):834–51. https://doi.org/10.1007/s12265-013-9508-6.

Article  PubMed  Google Scholar 

Kamat MA, Blackshaw JA, Young R, Surendran P, Burgess S, Danesh J, et al. PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations. Bioinformatics. 2019;35(22):4851–3. https://doi.org/10.1093/bioinformatics/btz469.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Kanai M, Akiyama M, Takahashi A, Matoba N, Momozawa Y, Ikeda M, et al. Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. Nat Genet. 2018;50(3):390–400. https://doi.org/10.1038/s41588-018-0047-6.

CAS  Article  PubMed  Google Scholar 

Keser T, Gornik I, Vučković F, Selak N, Pavić T, Lukić E, et al. Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes. Diabetologia. 2017;60(12):2352–60. https://doi.org/10.1007/s00125-017-4426-9.

CAS  Article  PubMed  Google Scholar 

Khan MAB, Hashim MJ, King JK, Govender RD, Mustafa H, Al KJ. Epidemiology of type 2 diabetes—global burden of disease and forecasted trends. J Epidemiol Glob Health. 2020;10(1):107–11. https://doi.org/10.2991/jegh.k.191028.001.

Article  PubMed  PubMed Central  Google Scholar 

Klarić L, Tsepilov YA, Stanton CM, Mangino M, Sikka TT, Esko T, et al. Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases. Sci Adv. 2020;6(8):eaax0301. https://doi.org/10.1126/sciadv.aax0301.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Krištić J, Lauc G. Ubiquitous importance of protein glycosylation. Methods Mol Biol. 2017;1503:1–12. https://doi.org/10.1007/978-1-4939-6493-2_1.

CAS  Article  PubMed  Google Scholar 

Krištić J, Vučković F, Menni C, Klarić L, Keser T, Beceheli I, et al. Glycans are a novel biomarker of chronological and biological ages. J Gerontol A Biol Sci Med Sci. 2014;69(7):779–89. https://doi.org/10.1093/gerona/glt190.

CAS  Article  PubMed  Google Scholar 

Kronimus Y, Dodel R, Galuska SP, Neumann S. IgG Fc N-glycosylation: alterations in neurologic diseases and potential therapeutic target? J Autoimmun. 2019;96:14–23. https://doi.org/10.1016/j.jaut.2018.10.006.

CAS  Article  PubMed  Google Scholar 

Lemmers RFH, Vilaj M, Urda D, Agakov F, Šimurina M, Klaric L, et al. IgG glycan patterns are associated with type 2 diabetes in independent European populations. Biochim Biophys Acta Gen Subj. 2017;1861(9):2240–9. https://doi.org/10.1016/j.bbagen.2017.06.020.

CAS  Article  PubMed  Google Scholar 

Li X, Wang H, Russell A, Cao W, Wang X, Ge S, et al. Type 2 diabetes mellitus is associated with the immunoglobulin G N-glycome through putative proinflammatory mechanisms in an Australian Population. OMICS. 2019;23(12):631–9. https://doi.org/10.1089/omi.2019.0075.

CAS  Article  PubMed  Google Scholar 

Liang B, Tang WW, Zhang WQ, Huang C, Liu Y, Xu F, et al. Prevalence and associated factors of diabetes mellitus in a very elderly Chinese population: a cross-sectional study. Biomed Environ Sci. 2020;33(5):315–22. https://doi.org/10.3967/bes2020.043.

Article  PubMed  Google Scholar 

Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, et al. Genome analyses of >200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders. Am J Hum Genet. 2018;103(5):691–706. https://doi.org/10.1016/j.ajhg.2018.09.009.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Liu D, Chu X, Wang H, Dong J, Ge SQ, Zhao ZY, et al. The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia. J Transl Med. 2018a;16(1):235. https://doi.org/10.1186/s12967-018-1616-2.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Liu D, Zhao Z, Wang A, Ge S, Wang H, Zhang X, et al. Ischemic stroke is associated with the pro-inflammatory potential of N-glycosylated immunoglobulin G. J Neuroinflamm. 2018b;15(1):123. https://doi.org/10.1186/s12974-018-1161-1.

CAS  Article  Google Scholar 

Liu D, Xu X, Li Y, Zhang J, Zhang X, Li Q, et al. Immunoglobulin G N-glycan analysis by ultra-performance liquid chromatography. J vis Exp. 2020. https://doi.org/10.3791/60104.

Article  PubMed  Google Scholar 

Liu D, Tian QY, Zhang J, Hou HF, Li Y, Wang W, et al. Association between 25 hydroxyvitamin D concentrations and the risk of COVID-19: a Mendelian randomization study. Biomed Environ Sci. 2021;34(9):750–4. https://doi.org/10.3967/bes2021.104.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Liu D, Dong J, Zhang J, Xu X, Tian Q, Meng X, et al. Genome-wide mapping of plasma IgG N-glycan quantitative trait loci identifies a potentially causal association between IgG N-glycans and rheumatoid arthritis. J Immunol. 2022;208(11):2508–14. https://doi.org/10.4049/jimmunol.2100080.

CAS  Article  PubMed  Google Scholar 

Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet. 2018;50(4):559–71. https://doi.

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