Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases

ALS

Amyotrophic lateral sclerosis

AMPA

α-amino-3-hydroxy-5-methyl-4- isoxazole propionate

BDNF

Brain derived neurotrophic factor

GDNF

Glial cell derived neurotrophic factor

GIRK

G protein-coupled inward rectifying K+ channels

GLAST

Glutamate-aspartate transporter

GLT-1

Glutamate transporter-1

GPCR

G-protein coupled receptor

GSK3β

Glycogen synthase kinase 3β

MDD

Major depressive disorder

mGluR

Metabotropic glutamate receptor

mTOR

mammalian Target Of Rapamycin

NAM

Negative allosteric modulator

PAM

Positive allosteric modulator

PI3K

Phosphoinositide 3-kinase

SNc

Substantia nigra pars compacta

SNr

Substantia nigra pars reticulata

VGCC

Voltage-gated calcium channel

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