High serum uric acid levels are associated with worse cognitive performance: A cross-sectional study.

Abstract

Background The association between raised serum uric acid and cognitive dysfunction remains a debated issue. In the present study, we investigated whether serum uric acid is associated with cognitive performance in a cohort of healthy individuals in Qatar;

Methods We conducted a cross-sectional study on a cohort of individuals aged 40 to 80 years old, without a diagnosis of dementia, schizophrenia, and stroke, who participated in Qatar Biobank. Cognitive performance was assessed using the CANTAB’s paired episodic memory test and reaction time test. The participants were divided into two groups, one group with a normal serum uric acid level (<350 μmol/l) and the other with high serum uric acid levels (>350 μmol/l). Two multivariable linear regression models were applied to determine the association between serum uric acid and memory test performance score and between serum uric acid and reaction time test performance score;

Results A total of 996 individuals with median age 48.0 years, IQR: (44.5, 54.0), of which 48.2% were male, were included. After adjusted multivariable linear regression, high serum uric acid levels were strongly associated with poor performance in the paired episodic memory test (beta -6.25, 95%CI - 10.65 to -1.84, p= 0.006). However, after adjusted multivariable linear regression, we found no significant association between high serum uric acid and performance in the reaction time test (beta - 13.24, 95%CI -138.77 to 112.29, p= 0.836,);

Conclusions In a cohort of healthy individuals in Qatar, high serum uric acid levels are associated with worse performance in visual memory and new learning domains of cognitive function but no significant effect on processing speed function.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This study did not receive any funding

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

IRB of Qatar Biobank gave ethical approval for this work

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Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

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I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes

Data Availability

All data produced in the present work are contained in the manuscript

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