Nerves in gastrointestinal cancer: from mechanism to modulations

Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209–249 (2021).

PubMed  Article  Google Scholar 

Anderson, N. M. & Simon, M. C. The tumor microenvironment. Curr. Biol. 30, R921–R925 (2020).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Quante, M., Varga, J., Wang, T. C. & Greten, F. R. The gastrointestinal tumor microenvironment. Gastroenterology 145, 63–78 (2013).

PubMed  Article  Google Scholar 

Zahalka, A. H. & Frenette, P. S. Nerves in cancer. Nat. Rev. Cancer 20, 143–157 (2020). Prominent review highlighting the importance of nerves within the TME in a variety of cancer types.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mancino, M., Ametller, E., Gascon, P. & Almendro, V. The neuronal influence on tumor progression. Biochim. Biophys. Acta 1816, 105–118 (2011).

CAS  PubMed  Google Scholar 

Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011).

CAS  PubMed  Article  Google Scholar 

Hanahan, D. Hallmarks of cancer: new dimensions. Cancer Discov. 12, 31–46 (2022). Timely revisited view on the hallmarks of cancer, building on the original hallmarks.

CAS  PubMed  Article  Google Scholar 

Furness, J. B., Callaghan, B. P., Rivera, L. R. & Cho, H. J. The enteric nervous system and gastrointestinal innervation: integrated local and central control. Adv. Exp. Med. Biol. 817, 39–71 (2014).

PubMed  Article  Google Scholar 

Langley, J. N. The autonomic nervous system. Brain 26, 1–26 (1903).

Article  Google Scholar 

Furness, J. B. The Enteric Nervous System 1st edn, 288 (Blackwell Publishing, 2006).

Bon-Frauches, A. C. & Boesmans, W. The enteric nervous system: the hub in a star network. Nat. Rev. Gastroenterol. Hepatol. 17, 717–718 (2020).

PubMed  Article  Google Scholar 

Rao, M. & Gershon, M. D. The bowel and beyond: the enteric nervous system in neurological disorders. Nat. Rev. Gastroenterol. Hepatol. 13, 517–528 (2016).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Niesler, B., Kuerten, S., Demir, I. E. & Schafer, K. H. Disorders of the enteric nervous system - a holistic view. Nat. Rev. Gastroenterol. Hepatol. 18, 393–410 (2021).

PubMed  Article  Google Scholar 

Holland, A. M., Bon-Frauches, A. C., Keszthelyi, D., Melotte, V. & Boesmans, W. The enteric nervous system in gastrointestinal disease etiology. Cell Mol. Life Sci. 78, 4713–4733 (2021).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rademakers, G. et al. The role of enteric neurons in the development and progression of colorectal cancer. Biochim. Biophys. Acta 1868, 420–434 (2017). The first review summarizing the importance of enteric neurons in colorectal carcinogenesis, focusing on the link between the ENS, inflammation and CRC.

CAS  Google Scholar 

Schledwitz, A., Xie, G. & Raufman, J. P. Exploiting unique features of the gut-brain interface to combat gastrointestinal cancer. J. Clin. Invest. https://doi.org/10.1172/JCI143776 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Griffin, N. et al. Clinicopathological significance of nerves in esophageal cancer. Am. J. Pathol. 190, 1921–1930 (2020).

CAS  PubMed  Article  Google Scholar 

Xu, G. et al. Prognosis and progression of ESCC patients with perineural invasion. Sci. Rep. 7, 43828 (2017).

PubMed  PubMed Central  Article  Google Scholar 

Deng, J. et al. Prognostic value of perineural invasion in gastric cancer: a systematic review and meta-analysis. PLoS ONE 9, e88907 (2014).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Tianhang, L., Guoen, F., Jianwei, B. & Liye, M. The effect of perineural invasion on overall survival in patients with gastric carcinoma. J. Gastrointest. Surg. 12, 1263–1264 (2008).

PubMed  Article  Google Scholar 

Knijn, N., Mogk, S. C., Teerenstra, S., Simmer, F. & Nagtegaal, I. D. Perineural invasion is a strong prognostic factor in colorectal cancer: a systematic review. Am. J. Surg. Pathol. 40, 103–112 (2016). Systematic review depicting the prominence of perineural invasion by summarizing all evidence for its prognostic value for CRC.

PubMed  Article  Google Scholar 

Liebig, C. et al. Perineural invasion is an independent predictor of outcome in colorectal cancer. J. Clin. Oncol. 27, 5131–5137 (2009).

PubMed  PubMed Central  Article  Google Scholar 

Zhao, C. M. et al. Denervation suppresses gastric tumorigenesis. Sci. Transl. Med. https://doi.org/10.1126/scitranslmed.3009569 (2014). Leading research article uncovering the functional importance of parasympathetic nerves in gastric cancer and their highly valuable potential as therapeutic targets. This article paved the way to gain more insights into the role of the nervous system in (gastric) cancer.

Article  PubMed  PubMed Central  Google Scholar 

Albo, D. et al. Neurogenesis in colorectal cancer is a marker of aggressive tumor behavior and poor outcomes. Cancer 117, 4834–4845 (2011).

CAS  PubMed  Article  Google Scholar 

Mauffrey, P. et al. Progenitors from the central nervous system drive neurogenesis in cancer. Nature 569, 672–678 (2019).

CAS  PubMed  Article  Google Scholar 

Lu, R. et al. Neurons generated from carcinoma stem cells support cancer progression. Signal. Transduct. Target. Ther. 2, 16036 (2017).

PubMed  PubMed Central  Article  Google Scholar 

Weinstein, V. A., Druckerman, L. J., Lyons, A. S. & Colp, R. Gastroenterostomy and vagotomy in the treatment of duodenal ulcer. Ann. Surg. 141, 482–487 (1955).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kraft, R. O., Myers, J., Overton, S. & Fry, W. J. Vagotomy and the gastric ulcer. Am. J. Surg. 121, 122–128 (1971).

CAS  PubMed  Article  Google Scholar 

Calmels, S., Bereziat, J. C., Ohshima, H. & Bartsch, H. Bacterial formation of N-nitroso compounds from administered precursors in the rat stomach after omeprazole-induced achlorhydria. Carcinogenesis 12, 435–439 (1991).

CAS  PubMed  Article  Google Scholar 

Moller, H., Nissen, A. & Mosbech, J. Use of cimetidine and other peptic ulcer drugs in Denmark 1977-1990 with analysis of the risk of gastric cancer among cimetidine users. Gut 33, 1166–1169 (1992).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rabben, H. L., Zhao, C. M., Hayakawa, Y., Wang, T. C. & Chen, D. Vagotomy and gastric tumorigenesis. Curr. Neuropharmacol. 14, 967–972 (2016).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tatsuta, M., Iishi, H., Yamamura, H., Baba, M. & Taniguchi, H. Effects of bilateral and unilateral vagotomy on gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in Wistar rats. Int. J. Cancer 42, 414–418 (1988).

CAS  PubMed  Article  Google Scholar 

Kim, S. J. & Choi, C. W. Common locations of gastric cancer: review of research from the endoscopic submucosal dissection era. J. Korean Med. Sci. 34, e231 (2019).

PubMed  PubMed Central  Article  Google Scholar 

Cassaro, M. et al. Topographic patterns of intestinal metaplasia and gastric cancer. Am. J. Gastroenterol. 95, 1431–1438 (2000).

CAS  PubMed  Article  Google Scholar 

Liu, V. et al. Extrinsic intestinal denervation modulates tumor development in the small intestine of ApcMin/+ mice. J. Exp. Clin. Cancer Res. 34, 39 (2015).

PubMed  PubMed Central  Article  CAS  Google Scholar 

Nelson, R. L., Briley, S., Vaz, O. P. & Abcarian, H. The effect of vagotomy and pyloroplasty on colorectal tumor induction in the rat. J. Surg. Oncol. 51, 281–286 (1992).

CAS  PubMed  Article  Google Scholar 

Bayón Lara, A. M. et al. Colonic carcinogenesis in vagotomyzed rats. Rev. Esp. Enferm. Dig. 93, 576–586 (2001).

PubMed  Google Scholar 

Caygill, C. P., Hill, M. J., Hall, C. N., Kirkham, J. S. & Northfield, T. C. Increased risk of cancer at multiple sites after gastric surgery for peptic ulcer. Gut 28, 924–928 (1987).

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bundred, N. J. et al. Gastric surgery and the risk of subsequent colorectal cancer. Br. J. Surg. 72, 618–619 (1985).

CAS  PubMed  Article  Google Scholar 

Watt, P. C., Patterson, C. C. & Kennedy, T. L. Late mortality after vagotomy and drainage for duodenal ulcer. Br. Med. J. 288, 1335–1338 (1984).

CAS  Article  Google Scholar 

Tatsuta, M., Iishi, H., Baba, M. & Taniguchi, H. Inhibitions by 6-hydroxydopamine and neostigmine singly or together of gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in Wistar rats. Int. J. Cancer 51, 767–771 (1992).

CAS 

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