Abe K, Funaya S, Tsukioka D, Kawamura M, Suzuki Y, Suzuki MG, Schultz RM, Aoki F. Minor zygotic gene activation is essential for mouse preimplantation development. P Natl Acad Sci USA. 2018;115:E6780–8.

CAS  Article  Google Scholar 

Bahar Halpern K, Caspi I, Lemze D, Levy M, Landen S, Elinav E, Ulitsky I, Itzkovitz S. Nuclear retention of mRNA in mammalian tissues. Cell Rep. 2015;13:2653–62.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bates M, Jones SA, Zhuang X. Stochastic optical reconstruction microscopy (STORM): a method for superresolution fluorescence imaging. Cold Spring Harb Protoc. 2013;2013:498–520.

PubMed  Google Scholar 

Bedoschi G, Navarro PA, Oktay K. Chemotherapy-induced damage to ovary: mechanisms and clinical impact. Future Oncol. 2016;12:2333–44.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bhasin S, Kerr C, Oktay K, Racowsky C. the implications of reproductive aging for the health, vitality, and economic welfare of human societies. J Clin Endocr Metab. 2019;104:3821–5.

Article  Google Scholar 

Chen JL, Liu TZ, Gao J, Gao L, Zhou LL, Cai MJ, Shi Y, Xiong WY, Jiang JG, Tong T, et al. Variation in carbohydrates between cancer and normal cell membranes revealed by super-resolution fluorescence imaging. Adv Sci. 2016;3(12):1600270.

Article  CAS  Google Scholar 

Chu DP, Tian S, Qi L, Hao CJ, Xia HF, Ma X. Abnormality of maternal-to-embryonic transition contributes to MEHP-induced mouse 2-cell block. J Cell Physiol. 2013;228:753–63.

CAS  PubMed  Article  Google Scholar 

Danilin S, Sourbier C, Thomas L, Lindner V, Rothhut S, Dormoy V, Helwig JJ, Jacqmin D, Lang H, Massfelder T. Role of the RNA-binding protein HuR in human renal cell carcinoma. Carcinogenesis. 2010;31:1018–26.

CAS  PubMed  Article  Google Scholar 

Denkert C, Koch I, von Keyserlingk N, Noske A, Niesporek S, Dietel M, Weichert W. Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. Modern Pathol. 2006;19:1261–9.

CAS  Article  Google Scholar 

Galloway SM, McNatty KP, Cambridge LM, Laitinen MPE, Juengel JL, Jokiranta TS, McLaren RJ, Luiro K, Dodds KG, Montgomery GW, et al. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat Genet. 2000;25:279–83.

CAS  PubMed  Article  Google Scholar 

Gao J, Wang Y, Cai M, Pan Y, Xu H, Jiang J, Ji H, Wang H. Mechanistic insights into EGFR membrane clustering revealed by super-resolution imaging. Nanoscale. 2015;7:2511–9.

CAS  PubMed  Article  Google Scholar 

Grammatikakis I, Abdelmohsen K, Gorospe M. Posttranslational control of HuR function. Wiley Interdiscip Rev RNA. 2017;8(1):10.1002.

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74.

CAS  PubMed  Article  Google Scholar 

Heck KE, Schoendorf KC, Ventura SJ, Kiely JL. Delayed childbearing by education level in the United States, 1969–1994. Matern Child Health J. 1997;1:81–8.

CAS  PubMed  Article  Google Scholar 

Higgins A, Khan Z, Coddington CC, Hashmi SK, Hefazi M, Alkhateeb H, Litzow MR, Hogan WJ, Cathcart-Rake E, Thompson CA, et al. Utilization and outcomes of fertility preservation techniques in women undergoing allogeneic hematopoietic cell transplant. Biol Blood Marrow Tr. 2019;25:1232–9.

Article  Google Scholar 

Hupalowska A, Jedrusik A, Zhu M, Bedford MT, Glover DM, Zernicka-Goetz M. CARM1 and paraspeckles regulate pre-implantation mouse embryo development. Cell. 2018;175:1902-1916 e1913.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Jemal A, Ward EM, Johnson CJ, Cronin KA, Ma JM, Ryerson AB, Mariotto A, Lake AJ, Wilson R, Sherman RL, et al. Annual report to the nation on the status of cancer, 1975–2014, Featuring survival. Jnci-J Natl Cancer. 2017;I:109.

Google Scholar 

Jing YY, Zhou LL, Chen JL, Xu HJ, Sun JY, Cai MJ, Jiang JG, Gao J, Wang HD. Quantitatively mapping the assembly pattern of EpCAM on cell membranes with peptide probes. Anal Chem. 2020;92:1865–73.

CAS  PubMed  Article  Google Scholar 

Karim-Kos HE, Kiemeney LA, Louwman MW, Coebergh JW, de Vries E. Progress against cancer in the Netherlands since the late 1980s: an epidemiological evaluation. Int J Cancer. 2012;130:2981–9.

CAS  PubMed  Article  Google Scholar 

Lai M, Li X, Li J, Hu Y, Czajkowsky DM, Shao Z. Improved clearing of lipid droplet-rich tissues for three-dimensional structural elucidation. Acta Biochim Biophys Sin (shanghai). 2017;49:465–7.

CAS  Article  Google Scholar 

Lang M, Berry D, Passecker K, Mesteri I, Bhuju S, Ebner F, Sedlyarov V, Evstatiev R, Dammann K, Loy A, et al. HuR small-molecule inhibitor elicits differential effects in adenomatosis polyposis and colorectal carcinogenesis. Cancer Res. 2017;77:2424–38.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Levet F, Hosy E, Kechkar A, Butler C, Beghin A, Choquet D, Sibarita JB. SR-Tesseler: a method to segment and quantify localization-based super-resolution microscopy data. Nat Methods. 2015;12:1065–71.

CAS  PubMed  Article  Google Scholar 

Li J, Kawamura K, Cheng Y, Liu S, Klein C, Liu S, Duan EK, Hsueh AJW. Activation of dormant ovarian follicles to generate mature eggs. P Natl Acad Sci USA. 2010;107:10280–4.

CAS  Article  Google Scholar 

Li X, Zheng M, Xu B, Li D, Shen Y, Nie Y, Ma L, Wu J. Generation of offspring-producing 3D ovarian organoids derived from female germline stem cells and their application in toxicological detection. Biomaterials. 2021;279: 121213.

CAS  PubMed  Article  Google Scholar 

Lim SJ, Lee SH, Joo SH, Song JY, Choi SI. Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer. Cancer Res Treat. 2009;41:87–92.

PubMed  PubMed Central  Article  Google Scholar 

Liu HB, Muhammad T, Guo YS, Li MJ, Sha QQ, Zhang CX, Liu H, Zhao SG, Zhao H, Zhang H, et al. RNA-binding protein IGF2BP2/IMP2 is a critical maternal activator in early zygotic genome activation. Adv Sci. 2019;6(15):1900295.

Article  CAS  Google Scholar 

Liu B, Xu Q, Wang Q, Feng S, Lai F, Wang P, Zheng F, Xiang Y, Wu J, Nie J, et al. The landscape of RNA Pol II binding reveals a stepwise transition during ZGA. Nature. 2020a;587:139–44.

CAS  PubMed  Article  Google Scholar 

Liu RP, Wu KY, Li YJ, Sun R, Li XJY. Human antigen R: a potential therapeutic target for liver diseases. Pharmacol Res. 2020b;155:104684.

Liu YB, Li XZ, Zhang H, Zhang MM, Wei YL. HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer. Oncogene. 2021;40(12):2230–42.

Luo H, Li X, Tian GG, Li D, Hou C, Ding X, Hou L, Lyu Q, Yang Y, Cooney AJ, et al. Offspring production of ovarian organoids derived from spermatogonial stem cells by defined factors with chromatin reorganization. J Adv Res. 2021;33:81–98.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Meisner NC, Hintersteiner M, Mueller K, Bauer R, Seifert JM, Naegeli HU, Ottl J, Oberer L, Guenat C, Moss S, et al. Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat Chem Biol. 2007;3:508–15.

CAS  PubMed  Article  Google Scholar 

Ni J, Hu C, Li H, Li X, Fu Q, Czajkowsky DM, Guo Y, Shao Z. Significant improvement in data quality with simplified SCRB-seq. Acta Biochim Biophys Sin (shanghai). 2020;52:457–9.

CAS  Article  Google Scholar 

Niakan KK, Han JN, Pedersen RA, Simon C, Pera RAR. Human pre-implantation embryo development. Development. 2012;139:829–41.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Nishino M, Kurasawa Y, Evans R, Lin SH, Brinkley BR, Yu-Lee LY. NudC is required for Plk1 targeting to the kinetochore and chromosome congression. Curr Biol. 2006;16:1414–21.

CAS  PubMed  Article  Google Scholar 

Ohinata Y, Payer B, O’Carroll D, Ancelin K, Ono Y, Sano M, Barton SC, Obukhanych T, Nussenzweig M, Tarakhovsky A, et al. Blimp1 is a critical determinant of the germ cell lineage in mice. Nature. 2005;436:207–13.

CAS  PubMed  Article  Google Scholar 

Ovesny M, Krizek P, Borkovec J, Svindrych ZK, Hagen GM. ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging. Bioinformatics. 2014;30:2389–90.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Pabis M, Popowicz GM, Stehle R, Fernandez-Ramos D, Asami S, Warner L, Garcia-Maurino SM, Schlundt A, Martinez-Chantar ML, Diaz-Moreno I, et al. HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs. Nucleic Acids Res. 2019;47:1011–29.

CAS  PubMed  Article  Google Scholar 

Paz I, Kosti I, Ares M Jr, Cline M, Mandel-Gutfreund Y. RBPmap: a web server for mapping binding sites of RNA-binding proteins. Nucleic Acids Res. 2014;42:W361-367.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Reddy P, Liu L, Adhikari D, Jagarlamudi K, Rajareddy S, Shen Y, Du C, Tang WL, Hamalainen T, Peng SL, et al. Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science. 2008;319:611–3.

CAS  PubMed  Article  Google Scholar 

Richards NG, Rittenhouse DW, Freydin B, Cozzitorto JA, Grenda D, Rui H, Gonye G, Kennedy EP, Yeo CJ, Brody JR, et al. HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients. Ann Surg. 2010;252:499–506.

PubMed  Article  Google Scholar 

Ripin N, Boudet J, Duszczyk MM, Hinniger A, Faller M, Krepl M, Gadi A, Schneider RJ, Sponer J, Meisner-Kober NC, et al. Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal R