The burden of asthma, hay fever and eczema in adults in 17 countries: GAN Phase I study

This article has an editorial commentary: https://doi.org/10.1183/13993003.00440-2022

Global Asthma Network Study Group. Global Asthma Network Steering Group: M.I. Asher, Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; K. Bissell, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; C-Y. Chiang, International Union Against Tuberculosis and Lung Disease, Paris, France, and Division of Pulmonary Medicine, Dept of Internal Medicine, Wan Fang Hospital, Taipei Medical University, and Division of Pulmonary Medicine, Dept of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; A. El Sony, Epidemiological Laboratory for Public Health and Research, Khartoum, Sudan; E. Ellwood, P. Ellwood, Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; L. García-Marcos, Pediatric Allergy and Pulmonology Units, Virgen de la Arrixaca University Children's Hospital, University of Murcia and IMIB Bioresearch Institute, Murcia, and ARADyAL Allergy Network, Edificio Departamental-LAIB, Murcia, Spain; G.B. Marks, Respiratory and Environmental Epidemiology, University of New South Wales, Sydney, Australia; R. Masekela, Dept of Paediatrics and Child Health, Nelson R. Mandela School of Clinical Medicine, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa; E. Morales, Department of Public Health Sciences, University of Murcia, and IMIB Bio-health Research Institute, Edificio Departamental-LAIB, Murcia, Spain; K. Mortimer, Liverpool School of Tropical Medicine, Liverpool, UK; N. Pearce, Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK; D.P. Strachan, Population Health Research Institute, St George's, University of London, London, UK.

Global Asthma Network International Data Centres. GAN Global Centre: P. Ellwood, E. Ellwood, M.I. Asher, Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. Murcia, Spain: L. García-Marcos, Pediatric Allergy and Pulmonology Units, Virgen de la Arrixaca University Children's Hospital, University of Murcia and IMIB Bioresearch Institute, Murcia, and ARADyAL Allergy Network, Edificio Departamental-LAIB, Murcia, Spain; V. Perez-Fernández, Dept of Paediatrics, University of Murcia, and IMIB Bio-health Research Institute, Edificio Departamental-LAIB, Murcia Spain; E. Morales, Dept of Public Health Sciences, University of Murcia, and IMIB Bio-health Research Institute, Edificio Departamental-LAIB, Murcia, Spain; A. Martinez-Torres, Paediatric Allergy and Pulmonology Units and Nurse Research Group, Virgen de la Arrixaca University Children's Hospital, University of Murcia and IMIB Bio-health Research Institute, Edificio Departamental-LAIB, Murcia, Spain. London, UK: D.P. Strachan, Population Health Research Institute, St George's, University of London, London, UK; N. Pearce, S. Robertson and C.E. Rutter, Dept of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK; R.J. Silverwood, Dept of Medical Statistics, London School of Hygiene and Tropical Medicine, and Centre for Longitudinal Studies, UCL Social Research Institute, University College London, London, UK.

Global Asthma Network Adult Principal Investigators. Brazil: M. Urrutia Pereira, Federal University of Pampa, UNIPAMPA (Uruguaiana); Cameroon: G.A. Ajeagah, The University of Yaounde 1 (Yaounde); Costa Rica: M.E. Soto-Martínez, Hospital Nacional de Niños “Dr. Carlos Saénz Herrera”, Caja Costarricense Seguro Social – Universidad de Costa Rica, San José, Costa Rica; Greece: K. Priftis, National and Kapodistrian University of Athens, Athens; Honduras: J. Sanchez, Instituto Nacional Cardiopulmonar, Tegucigalpa; India: S.K. Kochar, Sardar Patel Medical College, Bikaner; M. Singh, Postgraduate Institute of Medical Education and Research, Chandigarh; N. Singh, Asthma Bhawan, Jaipur; N. Sit, National Allergy Asthma Bronchitis Institute, Kolkata; T.U. Sukumaran, Pushpagiri Institute of Medical Sciences and Research, Thiruvalla, Kottayam; S. Awasthi, King George's Medical University, Lucknow; P.A. Mahesh, JSS Medical College, JSSAHER, Mysuru; S. Sinha, All India Institute of Medical Sciences, New Delhi; M. Barne, Chest Research Foundation, Pune; Iran: M. Tavakol, Alborz University of Medical Sciences, Karaj; N. Behniafard, Shahid Sadoughi University of Medical Sciences, Yazd; Kingdom of Saudi Arabia: S.A. Alomary, Ministry of Health, Kingdom of Saudi Arabia; Kosovo: I. Bucaliu-Ismajli, The Principal Center of Family Care, Ferizaj; L. Hana-Lleshi, General Hospital “Isa Grezda” Gjakova, Kosovo; V. Gashi, American Hospital in Kosovo, Gjilan; X. Kurhasani, UBT College Kosovo, Peja; B. Gacaferri-Lumezi, University of Prishtina Hasan Prishtina, Peja 6–7; L.N. Ahmetaj (national coordinator), University Hospital (Prishtina); V. Lokaj-Berisha, University of Prishtina, Prizren; México: M.G. Sanchez Coronel, COMPEDIA (Colegio Mexicano de Pediatras Especialistas en Inmunología y Alergia), Aguascalientes; G. Ochoa-Lopez, Department of Pediatric Allergology, Ciudad Juárez; R. García-Almaráz, Hospital Infantil de Tamaulipas, Ciudad Victoria; J.A. Sacre Hazouri, Instituto Privado de Alergia, Córdoba; M.d.J. Ambriz-Moreno, Hospital General de Matamoros Tamaulipas, Mexico “Dr. Alfredo Pumarejo Lafaurie”, Matamoros; J.V. Mérida-Palacio, Centro de Investigacion de Enfermedades Alergicas y Respiratorias, Mexicali; O.J. Saucedo-Ramirez, Hospital Angeles Pedregal, Mexico City North; L.O. Hernández-Mondragón, CRIT de Michoacán, Michoacán); A. Arias-Cruz, Hospital Universitario, Monterrey; C.A. Jiménez González, Universidad Autonoma of San Luis Potosí, San Luis Potosí; A.J. Escalante-Dominguez, Hospital General Tijuana, Isesalud, Tijuana; F.J. Linares-Zapién, Centro De Enfermedades Alergicas Y Asma de Toluca, Toluca Rural Area; E.M. Navarrete-Rodriguez, Hospital Infantil de México Federico Gómez, Toluca Urban Area; New Zealand: I. Asher, University of Auckland, Auckland; Nigeria: A.G. Falade, University of Ibadan and University College Hospital, Ibadan; Poland: G. Brożek, Medical University of Silesia, Katowice; Russia: K. Kyzmicheva, Tyumen State Medical University, Tyumen; Spain: L. García-Marcos (national coordinator), Pediatric Allergy and Pulmonology Units, Virgen de la Arrixaca University Children's Hospital, University of Murcia and IMIB Bioresearch Institute, Murcia, Cartagena; Taiwan: K. Yeh, Chang Gung Memorial Hospital, Taipei; Thailand: S. Chinratanapisit, Department of Pediatrics, Bhumibol Adulyadej Hospital, Royal Thai Air Force, Bangkok. Global Asthma Network National Co-ordinators not named above: Brazil: D. Solé, Escola Paulista de Medicina, Federal University of São Paulo; Costa Rica: M.E. Soto-Quirós, University of Costa Rica; India: V. Singh, Asthma Bhawan; Kingdom of Saudi Arabia: W.A. Althagafi, Ministry of Health; México: B.E. Del Río Navarro, Service of Allergy and Clinical Immunology, Hospital Infantil de México, México City; Thailand: P. Vichyanond, Mahidol University, Phutthamonthon.

Data sharing: The study protocol including a recommended informed consent form and statistical analysis plan are in the public domain (http://globalasthmanetwork.org/surveillance/surveillance.php). The GAN Phase I data, including de-identified individual participant data, will be password protected and made available on the Global Asthma Network website http://www.globalasthmanetwork.org/ within 12 months of all GAN Phase I analyses being published. Access for non-GAN researchers will require a formal request to the GAN steering group for consideration, by submission of a written proposal and, on acceptance, a signed data access agreement.

Author contributions: The following individual contributions were made. Conceptualisation: M.I. Asher, K. Bissell, C-Y. Chiang, A. El Sony, P. Ellwood, L. García-Marcos, G.B. Marks, N. Pearce and D.P. Strachan; data curation: E. Ellwood, P. Ellwood, L. García-Marcos, E. Morales, V. Perez-Fernandez, C.E. Rutter, S. Robertson, R.J. Silverwood and M. Lesosky; verification of the underlying data: C.E. Rutter, N. Pearce, V. Perez-Fernandez and D.P. Strachan; formal analysis: M. Lesosky, N. Pearce, C.E. Rutter and D.P. Strachan; investigation: M.I. Asher; methodology: M.I. Asher, C-Y. Chiang, P. Ellwood, L. García-Marcos, N. Pearce, C.E. Rutter, D.P. Strachan and R.J. Silverwood; project administration: M.I. Asher, E. Ellwood and P. Ellwood; resources: M.I. Asher; supervision: L. García-Marcos, N. Pearce, D.P. Strachan and R.J. Silverwood; validation: P. Ellwood; visualisation: E. Ellwood, P. Ellwood and C.E. Rutter; writing original draft: K. Mortimer and C-Y. Chiang; manuscript review/editing: M.I. Asher, G.B. Marks, A. Martínez-Torres, S. Robertson, C.E. Rutter, K. Bissell, A. El Sony, E. Ellwood, P. Ellwood, L. García-Marcos, E. Morales, V. Perez-Fernandez, N. Pearce, D.P. Strachan, R.J. Silverwood, M. Lesosky and the Global Asthma Network Phase I Study Group; the latter contributed original data to the analyses. All authors shared responsibility for the decision to submit the manuscript.

Conflict of interest: The authors declare that they have no conflict of interest.

Support statement: This work was supported by the International Union Against Tuberculosis and Lung Disease, Boehringer Ingelheim New Zealand, AstraZeneca Educational Grant, National Institute for Health Research, UK Medical Research Council, European Research Council and Instituto de Salud Carlos III, Spain.

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