Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes

Members of the DZIF-TB cohort study group: Jan Heyckendorf (Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany), Sebastian Marwitz (Pathology of the Universal Medical Center Schleswig-Holstein (UKSH) and the Research Center Borstel, Campus Borstel, Airway Research Center North (ARCN); German Center for Lung Research (DZL), Germany), Maja Reimann (Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany), Korkut Avsar (Asklepios Fachkliniken München-Gauting, Munich, Germany), Andrew DiNardo (The Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, USA), Gunar Günther (Department of Medicine, University of Namibia School of Medicine, Windhoek, Namibia; Inselspital Bern, Department of Pulmonology, Bern, Switzerland), Michael Hoelscher (Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany; German Center for Infection Research (DZIF), partner site Munich, Germany), Elmira Ibraim (Institutul de Pneumoftiziologie “Marius Nasta”, MDR-TB Research Department, Bucharest, Romania), Barbara Kalsdorf (Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany), Stefan H.E. Kaufmann (Max Planck Institute for Infection Biology, Berlin, Germany; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany; Hagler Institute for Advanced Study, Texas A&M University, College Station, USA), Irina Kontsevaya (Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany), Frank van Leth (Department of Global Health, Amsterdam University Medical Centres, Location AMC, Amsterdam, The Netherlands; Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands), Anna Maria Mandalakas (The Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, USA), Florian P. Maurer (National and WHO Supranational Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany), Marius Müller (Sankt Katharinen-Krankenhaus, Frankfurt, Germany), Dörte Nitschkowski (Pathology of the Universal Medical Center Schleswig-Holstein (UKSH) and the Research Center Borstel, Campus Borstel, Airway Research Center North (ARCN); German Center for Lung Research (DZL), Germany), Ioana D. Olaru (London School of Hygiene and Tropical Medicine, London, UK; Biomedical Research and Training Institute, Harare, Zimbabwe), Cristina Popa (Institutul de Pneumoftiziologie “Marius Nasta”, MDR-TB Research Department, Bucharest, Romania), Andrea Rachow (Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany; German Center for Infection Research (DZIF), partner site Munich, Germany), Thierry Rolling (Division of Infectious Diseases, I. Department of Internal Medicine, German Center for Infection Research (DZIF); University Medical Centre Hamburg-Eppendorf, Hamburg, Germany, Department of Clinical Immunology of Infectious Diseases, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany), Jan Rybniker (Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany), Helmut J.F. Salzer (Department of Pulmonology, Kepler University Hospital, Linz, Austria), Patricia Sanchez-Carballo (Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany), Maren Schuhmann (Universitäts Thoraxklinik-Heidelberg, Heidelberg, Germany), Dagmar Schaub (Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany), Victor Spinu (Institutul de Pneumoftiziologie “Marius Nasta”, MDR-TB Research Department, Bucharest, Romania), Isabelle Suárez (German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany), Elena Terhalle (Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany), Markus Unnewehr (Department of Respiratory Medicine and Infectious Diseases, St. Barbara-Klinik, Hamm, Germany; University of Witten-Herdecke, Witten, Germany), January Weiner 3rd (Berlin Institute of HealthCUBI (Core Unit Bioinformatics), Berlin, Germany), Torsten Goldmann (Pathology of the Universal Medical Center Schleswig-Holstein (UKSH) and the Research Center Borstel, Campus Borstel, Airway Research Center North (ARCN); German Center for Lung Research (DZL), Germany), Christoph Lange (Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany; German Center for Infection Research (DZIF), Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany; The Global Tuberculosis Program, Texas Children's Hospital, Immigrant and Global Health, Department of Pediatrics, Baylor College of Medicine, Houston, USA)..

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