Trait-like white matter abnormalities in current and remitted depression

Elsevier

Available online 11 September 2022, 111544

Psychiatry Research: NeuroimagingHighlights•

Whiter matter integrity in the corpus callosum and coronal radiate decreased in MDD.

Current and remitted depression exhibited similar whiter matter lesion patterns

Whiter matter lesions cannot recover during the state of natural remission of MDD.

Abstract

Microstructural alterations to white matter (WM) have been implicated in the onset and recurrence of major depressive disorder (MDD). The present study aimed to identify trait-like WM abnormality in current and remitted depression, as well as changes to WM that could be specifically related to the state of clinical remission. Diffusion tensor imaging data were collected from 60 patients with medication-naive first episode current depression (cMDD), 41 patients with medication-naive remitted depression (rMDD), and 62 demographically-matched healthy control participants (HCs). Tract-based spatial statistics (TBSS) applied to the whole brain were used to detect microstructural differences of WM among the three groups. TBSS analyses showed that, compared with HCs, both the cMDD and rMDD groups exhibited significantly reduced FA values in the genus and body of the corpus callosum, and superior and anterior corona radiata, with no significant differences between the cMDD and rMDD groups. FA values in the corpus callosum were negatively correlated with the duration of illness in the rMDD group. Reduced WM integrity in the corpus callosum and corona radiata might reflect the trait markers of MDD, and could constitute a neuroanatomical marker of MDD.

Keywords

Major depressive disorder

Remission

White matter

Diffusion tensor imaging

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