The bright frontiers of microbial metabolic optogenetics

ElsevierVolume 71, December 2022, 102207Current Opinion in Chemical BiologyAbstract

In recent years, light-responsive systems from the field of optogenetics have been applied to several areas of metabolic engineering with remarkable success. By taking advantage of light's high tunability, reversibility, and orthogonality to host endogenous processes, optogenetic systems have enabled unprecedented dynamical controls of microbial fermentations for chemical production, metabolic flux analysis, and population compositions in co-cultures. In this article, we share our opinions on the current state of this new field of metabolic optogenetics.We make the case that it will continue to impact metabolic engineering in increasingly new directions, with the potential to challenge existing paradigms for metabolic pathway and strain optimization as well as bioreactor operation.

Keywords

Metabolic engineering

Optogenetics

Cybergenetics

Biosensors

Control

Dynamic control of microbial fermentations: Design build test learn cycle

DBTL

Multivariate modular metabolic engineering

MMME

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