MacNeil A, Rollin PE. Ebola and Marburg hemorrhagic fevers: neglected tropical diseases? PLoS Negl Trop Dis. 2012;6:e1546.
PubMed PubMed Central Article Google Scholar
Rghei AD, van Lieshout LP, Santry LA, Guilleman MM, Thomas SP, Susta L, et al. AAV Vectored Immunoprophylaxis for Filovirus Infections. Trop Med Infect Dis. 2020;5:169.
Howley PM, Knipe DM, Whelan S. Fields Virology: Emerging Viruses, Lippincott Williams & Wilkins (LWW), 2020.
Heymann DL, Chen L, Takemi K, Fidler DP, Tappero JW, Thomas MJ, et al. Global health security: the wider lessons from the west African Ebola virus disease epidemic. Lancet. 2015;385:1884–901.
PubMed PubMed Central Article Google Scholar
Coltart CE, Lindsey B, Ghinai I, Johnson AM, Heymann DL. The Ebola outbreak, 2013–2016: old lessons for new epidemics. Philos Trans R Soc Lond B Biol Sci. 2017;372:20160297.
Towner JS, Pourrut X, Albariño CG, Nkogue CN, Bird BH, Grard G, et al. Marburg virus infection detected in a common African bat. PLoS One. 2007;2:e764.
PubMed PubMed Central Article CAS Google Scholar
History of Marburg Virus Disease (MVD) Outbreaks|Marburg (Marburg Virus Disease) | CDC. In, 2022.
Dulin N, Spanier A, Merino K, Hutter JN, Waterman PE, Lee C, et al. Systematic review of Marburg virus vaccine nonhuman primate studies and human clinical trials. Vaccine. 2021;39:202–8.
CAS PubMed Article Google Scholar
Dibo M, Battocchio EC, Dos Santos Souza LM, da Silva MDV, Banin-Hirata BK, Sapla MMM, et al. Antibody therapy for the control of viral diseases: an update. Curr Pharm Biotechnol. 2019;20:1108–21.
CAS PubMed Article Google Scholar
Banadyga L, Schiffman Z, He S, Qiu X. Virus inoculation and treatment regimens for evaluating anti-filovirus monoclonal antibody efficacy. Biosaf Health. 2019;1:6–13.
PubMed PubMed Central Article Google Scholar
Tshiani Mbaya O, Mukumbayi P, Mulangu S. Review: insights on current FDA-approved monoclonal antibodies against Ebola Virus Infection. Front Immunol. 2021;12:721328.
PubMed PubMed Central Article CAS Google Scholar
Fausther-Bovendo H, Kobinger G. The road to effective and accessible antibody therapies against Ebola virus. Curr Opin Virol. 2022;54:101210.
CAS PubMed Article Google Scholar
Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, et al. Mechanism of human antibody-mediated neutralization of Marburg virus. Cell. 2015;160:893–903.
CAS PubMed PubMed Central Article Google Scholar
King LB, Fusco ML, Flyak AI, Ilinykh PA, Huang K, Gunn B, et al. The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe. 2018;23:101–109.
CAS PubMed PubMed Central Article Google Scholar
Brannan JM, He S, Howell KA, Prugar LI, Zhu W, Vu H, et al. Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates. Nat Commun. 2019;10:105.
PubMed PubMed Central Article CAS Google Scholar
Mire CE, Geisbert JB, Borisevich V, Fenton KA, Agans KN, Flyak AI, et al. Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody. Sci Transl Med. 2017;9:384.
Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature. 2013;503:224–8.
CAS PubMed PubMed Central Article Google Scholar
Ledgerwood JE, Coates EE, Yamshchikov G, Saunders JG, Holman L, Enama ME, et al. Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults. Clin Exp Immunol. 2015;182:289–301.
CAS PubMed PubMed Central Article Google Scholar
Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Buckley N, et al. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature. 2015;522:487–91.
CAS PubMed PubMed Central Article Google Scholar
Mulangu S, Dodd LE, Davey RT, Tshiani Mbaya O, Proschan M, Mukadi D, et al. A randomized, controlled Trial of Ebola Virus Disease Therapeutics. N Engl J Med. 2019;381:2293–303.
CAS PubMed Article Google Scholar
Sanders JW, Ponzio TA. Vectored immunoprophylaxis: an emerging adjunct to traditional vaccination. Trop Dis Travel Med Vaccines. 2017;3:3.
PubMed PubMed Central Article Google Scholar
Schnepp BC, Johnson PR. Vector-mediated antibody gene transfer for infectious diseases. Adv Exp Med Biol. 2015;848:149–67.
CAS PubMed Article Google Scholar
Kuzmin DA, Shutova MV, Johnston NR, Smith OP, Fedorin VV, Kukushkin YS, et al. The clinical landscape for AAV gene therapies. Nat Rev Drug Discov. 2021;20:173–4.
CAS PubMed Article Google Scholar
Lewis AD, Chen R, Montefiori DC, Johnson PR, Clark KR. Generation of neutralizing activity against human immunodeficiency virus type 1 in serum by antibody gene transfer. J Virol. 2002;76:8769–75.
CAS PubMed PubMed Central Article Google Scholar
Balazs AB, Chen J, Hong CM, Rao DS, Yang L, Baltimore D. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature. 2012;481:81–4.
Balazs AB, Ouyang Y, Hong CM, Chen J, Nguyen SM, Rao DS, et al. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat Med. 2014;20:296–300.
CAS PubMed PubMed Central Article Google Scholar
Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D. Broad protection against influenza infection by vectored immunoprophylaxis in mice. Nat Biotechnol. 2013;31:647–52.
CAS PubMed PubMed Central Article Google Scholar
Limberis MP, Adam VS, Wong G, Gren J, Kobasa D, Ross TM, et al. Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza. Sci Transl Med. 2013;5:187ra72.
PubMed PubMed Central Article CAS Google Scholar
van Lieshout LP, Soule G, Sorensen D, Frost KL, He S, Tierney K, et al. Intramuscular Adeno-Associated Virus-Mediated Expression of Monoclonal Antibodies Provides 100% Protection Against Ebola Virus Infection in Mice. J Infect Dis. 2018;217:916–25.
PubMed PubMed Central Article CAS Google Scholar
Robert MA, Nassoury N, Chahal PS, Venne MH, Racine T, Qiu X, et al. Gene Transfer of ZMapp Antibodies Mediated by Recombinant Adeno-Associated Virus Protects Against Ebola Infections. Hum Gene Ther. 2018;29:452–66.
CAS PubMed Article Google Scholar
Deal C, Balazs AB, Espinosa DA, Zavala F, Baltimore D, Ketner G. Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice. Proc Natl Acad Sci USA. 2014;111:12528–32.
CAS PubMed PubMed Central Article Google Scholar
Fang J, Qian JJ, Yi S, Harding TC, Tu GH, VanRoey M, et al. Stable antibody expression at therapeutic levels using the 2A peptide. Nat Biotechnol. 2005;23:584–90.
CAS PubMed Article Google Scholar
Rghei AD, Stevens BAY, Thomas SP, Yates JGE, McLeod BM, Karimi K, et al. Production of Adeno-Associated Virus Vectors in Cell Stacks for Preclinical Studies in Large Animal Models. J Vis Exp. 2021;172:e62727.
van Lieshout LP, Domm JM, Wootton SK. AAV-mediated gene delivery to the Lung. Methods Mol Biol. 2019;1950:361–72.
PubMed Article CAS Google Scholar
Guilleman MM, Stevens BAY, Van Lieshout LP, Rghei AD, Pei Y, Santry LA, et al. AAV-mediated delivery of actoxumab and bezlotoxumab results in serum and mucosal antibody concentrations that provide protection from C. difficile toxin challenge. Gene Ther. 2021 https://doi.org/10.1038/s41434-021-00236-y.
Mingozzi F, Meulenberg JJ, Hui DJ, Basner-Tschakarjan E, Hasbrouck NC, Edmonson SA, et al. AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells. Blood. 2009;114:2077–86.
CAS PubMed PubMed Central Article Google Scholar
Manno CS, Chew AJ, Hutchison S, Larson PJ, Herzog RW, Arruda VR, et al. AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B. Blood. 2003;101:2963–72.
CAS PubMed Article Google Scholar
Katz MG, Swain JD, White JD, Low D, Stedman H, Bridges CR. Cardiac gene therapy: optimization of gene delivery techniques in vivo. Hum Gene Ther. 2010;21:371–80.
CAS PubMed PubMed Central Article Google Scholar
French BA, Mazur W, Geske RS, Bolli R. Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors. Circulation. 1994;90:2414–24.
CAS PubMed Article Google Scholar
Hunanyan AS, Kantor B, Puranam RS, Elliott C, McCall A, Dhindsa J, et al. Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3 Mashl/+, Mouse Model of Alternating Hemiplegia of Childhood. Hum Gene Ther. 2021;32:405–19.
CAS PubMed PubMed Central Article Google Scholar
Mayer B, Zolnai A, Frenyó LV, Jancsik V, Szentirmay Z, Hammarström L, et al. Redistribution of the sheep neonatal Fc receptor in the mammary gland around the time of parturition in ewes and its localization in the small intestine of neonatal lambs. Immunology. 2002;107:288–96.
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