Nicetto, D. & Zaret, K. S. Role of H3K9me3 heterochromatin in cell identity establishment and maintenance. Curr. Opin. Genet. Dev. 55, 1–10 (2019).
CAS PubMed PubMed Central Article Google Scholar
Elgin, S. C. & Reuter, G. Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila. Cold Spring Harb. Perspect. Biol. 5, a017780 (2013).
PubMed PubMed Central Article CAS Google Scholar
Grewal, S. I. & Jia, S. Heterochromatin revisited. Nat. Rev. Genet. 8, 35–46 (2007).
CAS PubMed Article Google Scholar
Janssen, A., Colmenares, S. U. & Karpen, G. H. Heterochromatin: guardian of the genome. Annu. Rev. Cell Dev. Biol. 34, 265–288 (2018).
CAS PubMed Article Google Scholar
Hall, I. M. et al. Establishment and maintenance of a heterochromatin domain. Science 297, 2232–2237 (2002).
CAS PubMed Article Google Scholar
Nakayama, J., Klar, A. J. & Grewal, S. I. A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis. Cell 101, 307–317 (2000).
CAS PubMed Article Google Scholar
Hathaway, N. A. et al. Dynamics and memory of heterochromatin in living cells. Cell 149, 1447–1460 (2012).
CAS PubMed PubMed Central Article Google Scholar
Audergon, P. N. et al. Epigenetics. Restricted epigenetic inheritance of H3K9 methylation. Science 348, 132–135 (2015).
CAS PubMed PubMed Central Article Google Scholar
Ragunathan, K., Jih, G. & Moazed, D. Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment. Science 348, 1258699 (2015).
PubMed Article CAS Google Scholar
Zhang, K., Mosch, K., Fischle, W. & Grewal, S. I. Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin. Nat. Struct. Mol. Biol. 15, 381–388 (2008).
CAS PubMed Article Google Scholar
Lee, N. N. et al. Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Cell 155, 1061–1074 (2013).
CAS PubMed PubMed Central Article Google Scholar
Tashiro, S., Asano, T., Kanoh, J. & Ishikawa, F. Transcription-induced chromatin association of RNA surveillance factors mediates facultative heterochromatin formation in fission yeast. Genes Cells 18, 327–339 (2013).
CAS PubMed Article Google Scholar
Volpe, T. A. et al. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297, 1833–1837 (2002).
CAS PubMed Article Google Scholar
Zofall, M. et al. RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation. Science 335, 96–100 (2012).
CAS PubMed Article Google Scholar
Al-Sady, B., Madhani, H. D. & Narlikar, G. J. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Mol. Cell 51, 80–91 (2013).
CAS PubMed PubMed Central Article Google Scholar
Muller, M. M., Fierz, B., Bittova, L., Liszczak, G. & Muir, T. W. A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nat. Chem. Biol. 12, 188–193 (2016).
CAS PubMed PubMed Central Article Google Scholar
Holla, S. et al. Positioning heterochromatin at the nuclear periphery suppresses histone turnover to promote epigenetic inheritance. Cell 180, 150–164 (2020).
CAS PubMed Article Google Scholar
Aygun, O., Mehta, S. & Grewal, S. I. HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin. Nat. Struct. Mol. Biol. 20, 547–554 (2013).
PubMed PubMed Central Article CAS Google Scholar
Taneja, N. et al. SNF2 family protein Fft3 suppresses nucleosome turnover to promote epigenetic inheritance and proper replication. Mol. Cell 66, 50–62 (2017).
CAS PubMed PubMed Central Article Google Scholar
Yamada, T., Fischle, W., Sugiyama, T., Allis, C. D. & Grewal, S. I. The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast. Mol. Cell 20, 173–185 (2005).
CAS PubMed Article Google Scholar
Sugiyama, T. et al. SHREC, an effector complex for heterochromatic transcriptional silencing. Cell 128, 491–504 (2007).
CAS PubMed Article Google Scholar
Job, G. et al. SHREC silences heterochromatin via distinct remodeling and deacetylation modules. Mol. Cell 62, 207–221 (2016).
CAS PubMed PubMed Central Article Google Scholar
Fischer, T. et al. Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast. Proc. Natl Acad. Sci. USA 106, 8998–9003 (2009).
Sadaie, M. et al. Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast. Mol. Cell. Biol. 28, 6973–6988 (2008).
CAS PubMed PubMed Central Article Google Scholar
Leopold, K., Stirpe, A. & Schalch, T. Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1. Genes Dev. 33, 565–577 (2019).
CAS PubMed PubMed Central Article Google Scholar
Cam, H. P., Noma, K., Ebina, H., Levin, H. L. & Grewal, S. I. Host genome surveillance for retrotransposons by transposon-derived proteins. Nature 451, 431–436 (2008).
CAS PubMed Article Google Scholar
Greenstein, R. A. et al. Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability. eLife 7, 32948 (2018).
Brehm, A. et al. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391, 597–601 (1998).
CAS PubMed Article Google Scholar
Raiymbek, G. et al. An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase. eLife 9, 53155 (2020).
Schultz, D. C., Friedman, J. R. & Rauscher, F. J. 3rd Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev. 15, 428–443 (2001).
CAS PubMed PubMed Central Article Google Scholar
Petrie, V. J., Wuitschick, J. D., Givens, C. D., Kosinski, A. M. & Partridge, J. F. RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast. Mol. Cell. Biol. 25, 2331–2346 (2005).
CAS PubMed PubMed Central Article Google Scholar
Schalch, T. et al. High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. Mol. Cell 34, 36–46 (2009).
CAS PubMed PubMed Central Article Google Scholar
Cutter DiPiazza, A. R. et al. Spreading and epigenetic inheritance of heterochromatin require a critical density of histone H3 lysine 9 tri-methylation. Proc. Natl Acad. Sci. USA 118, e2100699118 (2021).
CAS PubMed PubMed Central Article Google Scholar
Thon, G., Cohen, A. & Klar, A. J. Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe. Genetics 138, 29–38 (1994).
CAS PubMed PubMed Central Article Google Scholar
Canzio, D. et al. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol. Cell 41, 67–81 (2011).
CAS PubMed PubMed Central Article Google Scholar
Noma, K. et al. RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat. Genet. 36, 1174–1180 (2004).
CAS PubMed Article Google Scholar
Obersriebnig, M. J., Pallesen, E. M., Sneppen, K., Trusina, A. & Thon, G. Nucleation and spreading of a heterochromatic domain in fission yeast. Nat. Commun. 7, 11518 (2016).
CAS PubMed PubMed Central Article Google Scholar
Grewal, S. I. & Klar, A. J. Chromosomal inheritance of epigenetic states in fission yeast during mitosis and meiosis. Cell 86, 95–101 (1996).
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