Impersonating neurons

Subpopulations of glioblastoma cells (GBCs) have been shown to organize into tumour networks, facilitated by membranous structures known as tumour microtubes. These functional networks enable interconnectivity between tumour cells and other cells of the brain microenvironment, such as neurons, which in turn enables tumour cell proliferation and invasion and colonization of the brain. Yet there are other subpopulations of GBCs that remain to some extent isolated, and their role in tumour progression is uncertain. To address this phenomenon of intratumoral heterogeneity, Venkataramani et al. used longitudinal intravital two-photon imaging to track migrating GBCs in vivo.

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