Strength lies in difference

Cancer cells are characterized by transcriptional heterogeneity, which contributes to tumour progression, metastasis and treatment failure. In this study, Barkley and colleagues conducted single-cell RNA sequencing of almost 20,000 malignant cells derived from 62 untreated primary tumours of 15 cancer types. The researchers used non-negative matrix factorization to identify 16 sets of commonly co-expressed genes, also termed consensus modules. Some identified modules reflect cancer cells of origin (such as neurons and epithelial cells) or tissue environments (including the brain and reproductive tract). Others are shared by multiple tumour types.

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