Seppä-Moilanen M. · Andersson S. · Kirjavainen T.

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Children’s Hospital, and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Article / Publication Details

First-Page Preview

Received: March 09, 2022
Accepted: May 18, 2022
Published online: September 09, 2022

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Background: The effect of supplemental oxygen on sleep has not been studied in preterm infants. Methods: We studied 18 stable late-preterm infants with observed periodic breathing at a median gestational age of 36 weeks. Polysomnography was performed on room air and on 25% oxygen-enriched ambient air. Results: Supplemental oxygen did not affect sleep stage distribution, sleep efficiency, the frequency of sleep stage transitions, the appearance of rapid-eye movement (REM) sleep periods, or the high number of spontaneous arousals. The percentage in periodic breathing out of total sleep time decreased from 10% (interquartile range [IQR] 5–9%) on room air to 1% (IQR 0–3%) (p < 0.001) on supplemental oxygen. Also, the number of central apneas decreased from 48 (IQR 32–68) to 23 (IRQ 15–32) per hour (p < 0.001), and the number of oxygen desaturations of a minimum 3% from 38 (IQR 29–74) to 10 (IQR 5–24) per hour (p < 0.001). On room air in non-REM sleep, the median end-tidal carbon dioxide values were systematically lower during periodic breathing at 5.1 (IQR 4.6–6.4) kPa than during stable breathing at 5.5 (4.9–5.9) kPa (p < 0.0001). Conclusions: In late-preterm infants, supplemental oxygen effectively reduces periodic breathing and the number of oxygen desaturations while having no significant effect on sleep. The results support the importance of carotid body over-reactivity on the genesis of periodic breathing in preterm infants.

© 2022 S. Karger AG, Basel

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First-Page Preview

Received: March 09, 2022
Accepted: May 18, 2022
Published online: September 09, 2022

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

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