Wilson, M. C. et al. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 506, 58–62 (2014).
CAS PubMed Article Google Scholar
Elshahawi, S. I. et al. Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Proc. Natl Acad. Sci. USA 110, e295–e304 (2013).
CAS PubMed PubMed Central Article Google Scholar
Sit, C. S. et al. Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants. Proc. Natl Acad. Sci. USA 112, 13150–13154 (2015).
CAS PubMed PubMed Central Article Google Scholar
Ueoka, R. et al. Genome-based identification of a plant-associated marine bacterium as a rich natural product source. Angew. Chem. Int. Ed. 130, 14727–14731 (2018).
Waterworth, S. C. et al. Horizontal gene transfer to a defensive symbiont with a reduced genome in a multipartite beetle microbiome. mBio 11, e02430-19 (2020).
PubMed PubMed Central Article Google Scholar
Zan, J. et al. A microbial factory for defensive kahalalides in a tripartite marine symbiosis. Science 364, eaaw6732 (2019).
CAS PubMed Article Google Scholar
Tobias, N. J. et al. Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nat. Microbiol. 2, 1676–1685 (2017).
CAS PubMed Article Google Scholar
Rust, M. et al. A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli. Proc. Natl Acad. Sci. USA 117, 9508–9518 (2020).
CAS PubMed PubMed Central Article Google Scholar
Storey, M. A. et al. Metagenomic exploration of the marine sponge Mycale hentscheli uncovers multiple polyketide-producing bacterial symbionts. mBio 11, e02997-19 (2020).
PubMed PubMed Central Article Google Scholar
Freeman, M. F. et al. Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides. Science 338, 387–390 (2012).
CAS PubMed Article Google Scholar
Helfrich, E. J. N. & Piel, J. Biosynthesis of polyketides by trans-AT polyketide synthases. Nat. Prod. Rep. 33, 231–316 (2016).
CAS PubMed Article Google Scholar
Fuller, A. T. et al. Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens. Nature 234, 416–417 (1971).
CAS PubMed Article Google Scholar
El-Sayed, A. K. et al. Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586. Chem. Biol. 10, 419–430 (2003).
CAS PubMed Article Google Scholar
Pulsawat, N., Kitani, S. & Nihira, T. Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae. Gene 393, 31–42 (2007).
CAS PubMed Article Google Scholar
Mast, Y. et al. Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis. Microb. Biotechnol. 4, 192–206 (2011).
CAS PubMed PubMed Central Article Google Scholar
Cocito, C. G. Antibiotics of the virginiamycin family, inhibitors which contain synergistic components. Microbiol. Rev. 43, 145–198 (1979).
CAS PubMed PubMed Central Article Google Scholar
Pöplau, P., Frank, S., Morinaka, B. I. & Piel, J. An enzymatic domain for the formation of cyclic ethers in complex polyketides. Angew. Chem. Int. Ed. 52, 13215–13218 (2013).
Ueoka, R., Bortfeld-Miller, M., Morinaka, B. I., Vorholt, J. A. & Piel, J. Toblerols: cyclopropanol-containing polyketide modulators of antibiosis in Methylobacteria. Angew. Chem. Int. Ed. 130, 989–993 (2018).
Meoded, R. A. et al. A polyketide synthase component for oxygen insertion into polyketide backbones. Angew. Chem. Int. Ed. 57, 11644–11648 (2018).
Ma, M., Lohman, J. R., Liu, T. & Shen, B. C-S bond cleavage by a polyketide synthase domain. Proc. Natl Acad. Sci. USA 112, 10359–11364 (2015).
CAS PubMed PubMed Central Article Google Scholar
Chung, E. J., Park, J. A., Jeon, C. O. & Chung, Y. R. Gynuella sunshinyii gen. nov., sp. nov., an antifungal rhizobacterium isolated from a halophyte, Carex scabrifolia Steud. Int. J. Syst. Evol. Microbiol. 65, 1038–1043 (2015).
CAS PubMed Article Google Scholar
Blin, K. et al. AntiSMASH 5.0: updates to the secondary metabolite genome mining pipeline. Nucleic Acids Res. 47, W81–W87 (2019).
CAS PubMed PubMed Central Article Google Scholar
Helfrich, E. J. N. et al. Automated structure prediction of trans-acyltransferase polyketide synthase products. Nat. Chem. Biol. 15, 813–821 (2019).
CAS PubMed PubMed Central Article Google Scholar
Ueoka, R. et al. Genome mining of oxidation modules in trans-acyltransferase polyketide synthases reveals a culturable source for lobatamides. Angew. Chem. Int. Ed. 59, 7761–7765 (2020).
Chung, Y. R. & Khan, H. Novel nitrilase and method for preparing sangivamycin by using same. Patent KR20150047041A (2014).
Helfrich, E. J. N. et al. Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria. Nat. Commun. 12, 1422 (2021).
CAS PubMed PubMed Central Article Google Scholar
Nguyen, T. et al. Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat. Biotechnol. 26, 225–233 (2008).
CAS PubMed Article Google Scholar
Grindberg, R. V. et al. Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS ONE 6, e18565 (2011).
CAS PubMed PubMed Central Article Google Scholar
Luesch, H., Yoshida, W. Y., Moore, R. E., Paul, V. J. & Corbett, T. H. Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula. J. Am. Chem. Soc. 123, 5418–5423 (2001).
CAS PubMed Article Google Scholar
Buchholz, T. J. et al. Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase. Chem. Biol. 17, 1092–1100 (2010).
CAS PubMed PubMed Central Article Google Scholar
Davidson, S. K., Allen, S. W., Lim, G. E., Anderson, C. M. & Haygood, M. G. Evidence for the biosynthesis of bryostatins by the bacterial symbiont ‘Candidatus Endobugula sertula’ of the bryozoan Bugula neritina. Appl. Environ. Microbiol. 67, 4531–4537 (2001).
CAS PubMed PubMed Central Article Google Scholar
Skiba, M. A. et al. Repurposing the GNAT fold in the initiation of polyketide biosynthesis. Structure 28, 63–74 (2020).
CAS PubMed Article Google Scholar
Skiba, M. A. et al. A mononuclear iron-dependent methyltransferase catalyzes initial steps in assembly of the apratoxin A polyketide starter unit. ACS Chem. Biol. 12, 3039–3048 (2017).
CAS PubMed PubMed Central Article Google Scholar
Skiba, M. A. et al. Biosynthesis of t-butyl in apratoxin A: functional analysis and architecture of a PKS loading module. ACS Chem. Biol. 13, 1640–1650 (2018).
CAS PubMed PubMed Central Article Google Scholar
Röttig, M. et al. NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity. Nucleic Acids Res. 39, W362–W367 (2011).
PubMed PubMed Central Article CAS Google Scholar
Lu, S. et al. CDD/SPARCLE: the conserved domain database in 2020. Nucleic Acids Res. 48, D265–D268 (2020).
CAS PubMed Article Google Scholar
Hehre, W. et al. Efficient protocol for accurately calculating 13C chemical shifts of conformationally flexible natural products: scope, assessment and limitations. J. Nat. Prod. 82, 2299–2306 (2019).
CAS PubMed Article Google Scholar
Hwang, T.-L. & Shaka, A. J. Cross relaxation without TOCSY: transverse rotating-frame Overhauser effect spectroscopy. J. Am. Chem. Soc. 114, 3157–3159 (1992).
Nunez-Vergara, L. J. et al. Chromenopyridines: promising scaffolds for medicinal and biological chemistry. Curr. Med. Chem. 18, 4761–4785 (2011).
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