Zinc insulin hexamer loaded alginate zinc hydrogel: preparation, characterization and in vivo hypoglycemic ability

Elsevier

Available online 7 September 2022

European Journal of Pharmaceutics and BiopharmaceuticsHighlights•

Alginate zinc hydrogel loaded with zinc insulin hexamer was prepared;

Alginate hydrogel promote intestine absorption of insulin;

Zn-insulin loaded alginate hydrogel shows strong hypoglycemic ability.

Abstract

Alginate zinc hydrogel loaded with zinc insulin hexamer was prepared and characterized for oral insulin administration. The hydrogel was fabricated by dripping zinc insulin hexamer into sodium alginate solution and followed by crosslinking by zinc chloride. SEM image reveals the zinc insulin hexamer was integrated into the matrix of hydrogel. Zinc insulin hexamer loaded hydrogel shows no obvious cytotoxicity to both HT29 and Caco-2 cells. The developed hydrogel retards the burst release of insulin in simulated gastric fluid but promotes the release when in simulated intestinal fluid. In the diabetic mice, zinc insulin hexamer loaded alginate hydrogel demonstrates significant and prolonged hypoglycemic effect.

Keywords

Insulin

Sodium alginate

Maltodextrin

Hydrogel

Control release

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