Nia HT, Munn LL, Jain RK. Physical traits of cancer. Science 2020;370:eaaz0868.

CAS  Article  Google Scholar 

Noble R, Burri D, Sueur CL, Lemant J, Viossat Y, Kather JN, et al. Spatial structure governs the mode of tumour evolution. Nat Ecol Evol. 2022;6:207–17.

Article  Google Scholar 

Huang A, Pressnall MM, Lu R, Huayamares SG, Griffin JD, Groer C, et al. Human intratumoral therapy: linking drug properties and tumor transport of drugs in clinical trials. J Control Release. 2020;326:203–21.

CAS  Article  Google Scholar 

Zanotelli MR, Reinhart-King CA. Biomechanics in Oncology. Adv Exp Med Biol. 2018;1092:91–112.

CAS  Article  Google Scholar 

Khawar IA, Kim JH, Kuh HJ. Improving drug delivery to solid tumors: priming the tumor microenvironment. J Control Release. 2015;201:78–89.

CAS  Article  Google Scholar 

Sheth RA, Hesketh R, Kong DS, Wicky S, Oklu R. Barriers to drug delivery in interventional oncology. J Vasc Int Radiol. 2013;24:1201–7. http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23735316&retmode=ref&cmd=prlinks.

Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, et al. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat Commun. 2013;4:2516.

Article  Google Scholar 

Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma. Cancer Cell. 2012;21:418–29.

CAS  Article  Google Scholar 

Wang-Gillam A. Targeting stroma: a tale of caution. J Clin Oncol. 2019;37:JCO.19.00056.

Article  Google Scholar 

Bazan-Peregrino M, Garcia-Carbonero R, Laquente B, Álvarez R, Mato-Berciano A, Gimenez-Alejandre M, et al. VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects. J Immunother Cancer. 2021;9:e003254.

Article  Google Scholar 

Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol: Offic J Am Soc Clin Oncol. 2013;31:2205–18. http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2012.46.3653.

Mpekris F, Baish JW, Stylianopoulos T, Jain RK. Role of vascular normalization in benefit from metronomic chemotherapy. Proc Natl Acad Sci. 2017;114:1994–9.

CAS  Article  Google Scholar 

Li X, Ramadori P, Pfister D, Seehawer M, Zender L, Heikenwalder M. The immunological and metabolic landscape in primary and metastatic liver cancer. Nat Rev Cancer. 2021;21:541–57.

CAS  Article  Google Scholar 

Qu S, Worlikar T, Felsted AE, Ganguly A, Beems MV, Hubbard R, et al. Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy. J Immunother Cancer. 2020;8:e000200.

Article  Google Scholar 

Bilusic M, Gulley JL. Editorial: Local Immunotherapy: A Way to Convert Tumors From “Cold” to “Hot”. J Natl Cancer Inst. 2017;109:djx132.

Article  Google Scholar 

Murthy V, Minehart J, Sterman DH. Local immunotherapy of cancer: innovative approaches to harnessing tumor-specific immune responses. J Natl Cancer Inst. 2017;109. https://doi.org/10.1093/jnci/djx097.

Andtbacka RHI, Ross M, Puzanov I, Milhem M, Collichio F, Delman KA, et al. Patterns of Clinical Response with Talimogene Laherparepvec (T-VEC) in Patients with Melanoma Treated in the OPTiM Phase III Clinical Trial. Ann Surg Oncol. 2016;23:4169–77.

Article  Google Scholar 

Munoz NM, Williams M, Dixon K, Dupuis C, McWatters A, Avritscher R, et al. Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy. J Immunother Cancer. 2021;9:e001800. https://jitc.bmj.com/lookup/doi/10.1136/jitc-2020-001800.

Sheth RA, Murthy R, Hong DS, Patel S, Overman MJ, Diab A, et al. Assessment of Image-Guided Intratumoral Delivery of Immunotherapeutics in Patients With Cancer. JAMA Network Open. 2020;3:e207911–e207911. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2768765.

Lohr F, Huang Q, Hu K, Dewhirst MW, Li CY. Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors. Clin Cancer Res Off J Am Assoc Cancer Res. 2001;7:3625–8.

CAS  Google Scholar 

Marabelle A, Andtbacka R, Harrington K, Melero I, Leidner R, Baere Tde, et al. Starting the fight in the tumor: expert recommendations for the development of human intratumoral immunotherapy (HIT-IT). Ann Oncol. 2018;29:2163–74.

CAS  Article  Google Scholar 

Mehta AM, Sonabend AM, Bruce JN. Convection-Enhanced Delivery. Neurotherapeutics 2017;14:358–71.

CAS  Article  Google Scholar 

Krauze MT, Saito R, Noble C, Tamas M, Bringas J, Park JW, et al. Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents. J Neurosurg. 2005;103:923–9.

Article  Google Scholar 

Sillay KA, McClatchy SG, Shepherd BA, Venable GT, Fuehrer TS. Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain. J Vis Exp. 2014;e51466. https://doi.org/10.3791/5146.

Kunwar S, Chang S, Westphal M, Vogelbaum M, Sampson J, Barnett G, et al. Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma. Neuro-Oncol. 2010;12:871–81.

CAS  Article  Google Scholar 

Hu J, Albadawi H, Chong BW, Deipolyi AR, Sheth RA, Khademhosseini A, et al. Advances in Biomaterials and Technologies for Vascular Embolization. Adv Mater (Deerfield Beach, Fla). 2019;31:e1901071. https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201901071.

Rose SC, Narsinh KH, Newton IG. Quantification of Blood Pressure Changes in the Vascular Compartment When Using an Anti-Reflux Catheter during Chemoembolization versus Radioembolization: a retrospective case series. J Vasc Inter Radio. 2017;28:103–10.

Article  Google Scholar 

Fischman AM, Ward TJ, Patel RS, Arepally A, Kim E, Nowakowski FS, et al. Prospective, Randomized Study of Coil Embolization versus Surefire Infusion System during Yttrium-90 Radioembolization with Resin Microspheres. J Vasc Inter Radio. 2014;25:1709–16.

Article  Google Scholar 

Pasciak AS, McElmurray JH, Bourgeois AC, Heidel RE, Bradley YC. The Impact of an Antireflux Catheter on Target Volume Particulate Distribution in Liver-Directed Embolotherapy: a pilot study. J Vasc Inter Radio. 2015;26:660–9.

Article  Google Scholar 

d’Abadie P, Belgium D of NM Saint Luc University Hospital and King Albert II Cancer Institute, Brussels, Walrand S, Goffette P, Amini N, van Maanen A, et al. Antireflux catheter improves tumor targeting in liver radioembolization with resin microspheres. Diagn Inter Radio. 2021;27:768–73.

Article  Google Scholar 

Arepally A, Chomas J, Katz SC, Jaroch D, Kolli KP, Prince E, et al. Pressure-Enabled Drug Delivery Approach in the Pancreas with Retrograde Venous Infusion of Lipiodol with Ex Vivo Analysis. Cardiovasc Inter Rad. 2021;44:141–9.

Article  Google Scholar 

Adusumilli PS, Zauderer MG, Riviere I, Solomon SB, Rusch VW, O’Cearbhaill RE, et al. A phase I trial of regional mesothelin-targeted CAR T-cell therapy in patients with malignant pleural disease, in combination with the anti-PD-1 agent pembrolizumab. Cancer Discov. 2021;11:candisc.0407.2021.

Chai LF, Hardaway JC, Heatherton KR, O’Connell KP, LaPorte JP, Guha P, et al. Regional Delivery of CAR-T Effectively Controls Tumor Growth in Colorectal Liver Metastasis Model. J Surg Res. 2022;272:37–50.

Article  Google Scholar 

Szeligo BM, Ivey AD, Boone BA. Poor Response to Checkpoint Immunotherapy in Uveal Melanoma Highlights the Persistent Need for Innovative Regional Therapy Approaches to Manage Liver Metastases. Cancers 2021;13:3426.

CAS  Article  Google Scholar 

Burga RA, Thorn M, Point GR, Guha P, Nguyen CT, Licata LA, et al. Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T. Cancer Immunol Immunother. 2015;64:817–29.

CAS  Article  Google Scholar 

Yu J, Green MD, Li S, Sun Y, Journey SN, Choi JE, et al. Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Nat Med. 2021;27:152–64.

CAS  Article  Google Scholar 

Rantala ES, Hernberg M, Kivelä TT. Overall survival after treatment for metastatic uveal melanoma: a systematic review and meta-analysis. Melanoma Res. 2019;29:561–8.

Article  Google Scholar 

Meijer TS, Burgmans MC, Leede EM de, Geus-Oei LF de, Boekestijn B, Handgraaf HJM, et al. Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Ocular Melanoma Metastases Confined to the Liver: A Prospective Phase II Study. Ann Surg Oncol. 2021;28:1130–41.

Article  Google Scholar