State Key Laboratory of Natural Medicines, Center of Advanced Pharmaceuticals and Biomaterials, School of Pharmacy, China Pharmaceutical University, Nanjing, PR China.

Correspondence: Zhigui Su, PhD or Lingjing Xue, PhD, State Key Laboratory of Natural Medicines, Center of Advanced Pharmaceuticals and Biomaterials, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China (e-mail: [email protected] or [email protected]).

Supported by the National Natural Science Foundation of China (No.81973270, 82003694, 8210132135) and the Natural Science Foundation of Jiangsu Province of China for Excellent Young Scholars (No. BK20190078).

The authors report no conflicts of interest.

Z. Wang and J. Su are co-first authors.