Jacobson KA, Gao ZG. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov. 2006;5:247–64. https://doi.org/10.1038/nrd1983.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Stagg J, Smyth MJ. Extracellular adenosine triphosphate and adenosine in cancer. Oncogene. 2010;29:5346–58. https://doi.org/10.1038/onc.2010.292.

CAS  Article  PubMed  Google Scholar 

Fredholm BB, IJzerman AP, Jacobson KA, Linden J, Müller CE. International union of basic and clinical pharmacology. LXXXI. Nomenclature and classification of adenosine receptors—an update. Pharmacol Rev. 2011;63:1–34. https://doi.org/10.1124/pr.110.003285.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Allard B, Allard D, Buisseret L, Stagg J. The adenosine pathway in immuno-oncology. Nat Rev Clin Oncol. 2020;17:611–29. https://doi.org/10.1038/s41571-020-0382-2.

CAS  Article  PubMed  Google Scholar 

Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of adenosine receptors: the state of the art. Physiol Rev. 2018;98:1591–625. https://doi.org/10.1152/physrev.00049.2017.

CAS  Article  PubMed  Google Scholar 

Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pathological overproduction: the bad side of adenosine. Br J Pharmacol. 2017;174:1945–60. https://doi.org/10.1111/bph.13763.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Franco R, Cordomí A, Llinas del Torrent C, Lillo A, Serrano-Marín J, Navarro G, Pardo L. Structure and function of adenosine receptor heteromers. Cell Mol Life Sci. 2021;78:3957–68. https://doi.org/10.1007/s00018-021-03761-6.

CAS  Article  PubMed  Google Scholar 

Chen JF, Eltzschig HK, Fredholm BB. Adenosine receptors as drug targets-what are the challenges? Nat Rev Drug Discov. 2013;12:265–86. https://doi.org/10.1038/nrd3955.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Modlinger PS, Welch WJ. Adenosine A1 receptor antagonists and the kidney. Curr Opin Nephrol Hypertens. 2003;12:497–502. https://doi.org/10.1097/00041552-200309000-00003.

CAS  Article  PubMed  Google Scholar 

Nadeem A, Obiefuna PCM, Wilson CN, Mustafa SJ. Adenosine A1 receptor antagonist versus montelukast on airway reactivity and inflammation. Eur J Pharmacol. 2006;551:116–24. https://doi.org/10.1016/j.ejphar.2006.08.059.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Kashfi S, Ghaedi K, Baharvand H, Nasr-Esfahani MH, Javan M. A1 adenosine receptor activation modulates central nervous system development and repair. Mol Neurobiol. 2017;54:8128–39. https://doi.org/10.1007/s12035-016-0292-6.

CAS  Article  PubMed  Google Scholar 

Liu YJ, Chen J, Li X, Zhou X, Hu YM, Chu SF, Peng Y, Chen NH. Research progress on adenosine in central nervous system diseases. CNS Neurosci Ther. 2019;25:899–910. https://doi.org/10.1111/cns.13190.

Article  PubMed  PubMed Central  Google Scholar 

Bours MJL, Swennen ELR, Di Virgilio F, Cronstein BN, Dagnelie PC. Adenosine 5’-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006;112:358–404. https://doi.org/10.1016/j.pharmthera.2005.04.013.

CAS  Article  PubMed  Google Scholar 

Ren H, Stiles GL. Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. J Biol Chem. 1994;269:3104–10. https://doi.org/10.1016/s0021-9258(17)42054-0.

CAS  Article  PubMed  Google Scholar 

Glukhova A, Thal DM, Nguyen AT, Vecchio EA, Jörg M, Scammells PJ, May LT, Sexton PM, Christopoulos A. Structure of the adenosine A1 receptor reveals the basis for subtype selectivity. Cell. 2017;168:867-877.e13. https://doi.org/10.1016/j.cell.2017.01.042.

CAS  Article  PubMed  Google Scholar 

Jespers W, Schiedel AC, Heitman LH, Cooke RM, Kleene L, van Westen GJP, Gloriam DE, Müller CE, Sotelo E, Gutiérrez-de-Terán H. Structural mapping of adenosine receptor mutations: ligand binding and signaling mechanisms. Trends Pharmacol Sci. 2018;39:75–89. https://doi.org/10.1016/j.tips.2017.11.001.

CAS  Article  PubMed  Google Scholar 

Klinger M, Freissmuth M, Nanoff C. Adenosine receptors: G protein-mediated signalling and the role of accessory proteins. Cell Signal. 2002;14:99–108. https://doi.org/10.1016/S0898-6568(01)00235-2.

CAS  Article  PubMed  Google Scholar 

Effendi WI, Nagano T, Kobayashi K, Nishimura Y. Focusing on adenosine receptors as a potential targeted therapy in human diseases. Cells. 2020;9:1–36. https://doi.org/10.3390/cells9030785.

CAS  Article  Google Scholar 

Defer N, Best-belpomme M, Hanoune J, Cre F, Best-belpomme M, Hanoune J, Sutherland E. Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. Am J Physiol Ren Physiol. 2000;279:400–16. https://doi.org/10.1152/ajprenal.2000.279.3.F400.

Article  Google Scholar 

Liu AMF, Wong YH. G16-mediated activation of nuclear factor κB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling*. J Biol Chem. 2004;279:53196–204. https://doi.org/10.1074/jbc.M410196200.

CAS  Article  PubMed  Google Scholar 

Schulte G, Fredholm BB. Human adenosine A1, A(2A), A(2B), and A3 receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2. Mol Pharmacol. 2000;58:477–82. https://doi.org/10.1124/mol.58.3.477.

CAS  Article  PubMed  Google Scholar 

Faure M, Voyno-Yasenetskaya TA, Bourne HR. cAMP and βγ subunits of heterotrimeric G proteins stimulate the mitogen- activated protein kinase pathway in COS-7 cells. J Biol Chem. 1994;269:7851–4. https://doi.org/10.1016/s0021-9258(17)37127-2.

CAS  Article  PubMed  Google Scholar 

Schulte G, Fredholm BB. Signalling from adenosine receptors to mitogen-activated protein kinases. Cell Signal. 2003;15:813–27. https://doi.org/10.1016/S0898-6568(03)00058-5.

CAS  Article  PubMed  Google Scholar 

Deb PK, Deka S, Borah P, Abed SN, Klotz K-N. Medicinal chemistry and therapeutic potential of agonists, antagonists and allosteric modulators of A1 adenosine receptor: current status and perspectives. Curr Pharm Des. 2019;25:2697–715. https://doi.org/10.2174/1381612825666190716100509.

CAS  Article  PubMed  Google Scholar 

Yan L, Burbiel JC, Maaß A, Müller CE. Adenosine receptor agonists: from basic medicinal chemistry to clinical development. Expert Opin Emerg Drugs. 2003;8:537–76. https://doi.org/10.1517/14728214.8.2.537.

CAS  Article  PubMed  Google Scholar 

Klotz KN. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000;362:382–91. https://doi.org/10.1007/s002100000315.

CAS  Article  PubMed  Google Scholar 

Tosh DK, Phan K, Gao ZG, Gakh AA, Xu F, Deflorian F, Abagyan R, Stevens RC, Jacobson KA, Katritch V. Optimization of adenosine 5’-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. J Med Chem. 2012;55:4297–308. https://doi.org/10.1021/jm300095s.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bogatko K, Poleszak E, Szopa A, Wyska E, Wlaź P, Świąder K, Wlaź A, Doboszewska U, Rojek K, Serefko A. The influence of selective A1 and A2A receptor antagonists on the antidepressant-like activity of moclobemide, venlafaxine and bupropion in mice. J Pharm Pharmacol. 2018;70:1200–8. https://doi.org/10.1111/jphp.12954.

CAS  Article  PubMed  Google Scholar 

Müller CE, Jacobson KA. Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta - Biomembr. 1808;2011:1290–308. https://doi.org/10.1016/j.bbamem.2010.12.017.

CAS  Article  Google Scholar 

Hocher B. Adenosine A1 receptor antagonists in clinical research and development. Kidney Int. 2010;78:438–45. https://doi.org/10.1038/ki.2010.204.

CAS  Article  PubMed  Google Scholar 

Moro S, Gao ZG, Jacobson KA, Spalluto G. Progress in the pursuit of therapeutic adenosine receptor antagonists. Med Res Rev. 2006;26:131–59. https://doi.org/10.1002/med.20048.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Scheiff AB, Yerande SG, El-Tayeb A, Li W, Inamdar GS, Vasu KK, Sudarsanam V, Müller CE. 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorganic Med Chem. 2010;18:2195–203. https://doi.org/10.1016/j.bmc.2010.01.072.

CAS  Article  Google Scholar 

Muller CE. A1-adenosine receptor antagonists. Expert Opin Ther Pat. 1997;7:419–40. https://doi.org/10.1517/13543776.7.5.419.

CAS  Article  Google Scholar 

Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood. 2008;112:1822–31. https://doi.org/10.1182/blood-2008-02-136325.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Haskó G, Pacher P. Regulation of macrophage function by adenosine. Arterioscler Thromb Vasc Biol. 2012;32:865–9. https://doi.org/10.1161/ATVBAHA.111.226852.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Boyce BF. Advances in the regulation of osteoclasts and osteoclast functions. J Dent Res. 2013;92:860–7.