Bunchorntavakul C, Reddy KR. Review article: herbal and dietary supplement hepatotoxicity. Aliment Pharmacol Ther. 2013;37:3–17.
CAS PubMed Article Google Scholar
Federico A, Dallio M, Loguercio C. Silymarin/Silybin and chronic liver disease: a marriage of many years. Molecules. 2017;22:191.
PubMed Central Article CAS Google Scholar
Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. World J Gastroenterol. 2011;17:2288–301.
CAS PubMed PubMed Central Article Google Scholar
Janeczko M, Kochanowicz E. Silymarin, a popular dietary supplement shows anti-candida activity. Antibiotics. 2019;8:206.
CAS PubMed Central Article Google Scholar
Li Volti G, Salomone S, Sorrenti V, Mangiameli A, Urso V, Siarkos I, et al. Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice. Cardiovasc Diabetol. 2011;10:62.
CAS PubMed PubMed Central Article Google Scholar
Sciacqua A, Perticone M, Tripepi G, Addesi D, Cassano V, Maio R, et al. Metabolic and vascular effects of silybin in hypertensive patients with high 1-h post-load plasma glucose. Intern Emerg Med. 2019;14:77–84.
Li X, Lin Y, Zhou H, Li Y, Wang A, Wang H, et al. Puerarin protects against endothelial dysfunction and end-organ damage in Ang II-induced hypertension. Clin Exp Hypertens. 2017;39:58–64.
PubMed Article CAS Google Scholar
Gonzalez J, Valls N, Brito R, Rodrigo R. Essential hypertension and oxidative stress: new insights. World J Cardiol. 2014;6:353–66.
PubMed PubMed Central Article Google Scholar
Konukoglu D, Uzun H. Endothelial dysfunction and hypertension. Adv Exp Med Biol. 2017;956:511–40.
Heathcote HR, Lee MD, Zhang X, Saunter CD, Wilson C, McCarron JG. Endothelial TRPV4 channels modulate vascular tone by Ca2+-induced Ca2+ release at inositol 1,4,5-trisphosphate receptors. Br J Pharmacol. 2019;176:3297–317.
CAS PubMed PubMed Central Google Scholar
Filosa JA, Yao X, Rath G. TRPV4 and the regulation of vascular tone. J Cardiovasc Pharmacol. 2013;61:113–9.
CAS PubMed PubMed Central Article Google Scholar
Chen YL, Sonkusare SK. Endothelial TRPV4 channels and vasodilator reactivity. Curr Top Membr. 2020;85:89–117.
CAS PubMed Article Google Scholar
O’Neil RG, Heller S. The mechanosensitive nature of TRPV channels. Pflug Arch. 2005;451:193–203.
Cao S, Anishkin A, Zinkevich NS, Nishijima Y, Korishettar A, Wang Z, et al. Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation. J Biol Chem. 2018;293:5307–22.
CAS PubMed PubMed Central Article Google Scholar
Liu L, Guo M, Lv X, Wang Z, Yang J, Li Y, et al. Role of transient receptor potential vanilloid 4 in vascular function. Front Mol Biosci. 2021;8:677661.
CAS PubMed PubMed Central Article Google Scholar
Zhou T, Wang Z, Guo M, Zhang K, Geng L, Mao A, et al. Puerarin induces mouse mesenteric vasodilation and ameliorates hypertension involving endothelial TRPV4 channels. Food Funct. 2020;11:10137–48.
CAS PubMed Article Google Scholar
Shao J, Han J, Zhu Y, Mao A, Wang Z, Zhang K, et al. Curcumin induces endothelium-dependent relaxation by activating endothelial TRPV4 channels. J Cardiovasc Transl Res. 2019;12:600–7.
Zhang X, Mao A, Xiao W, Zhang P, Han X, Zhou T, et al. Morin induces endothelium-dependent relaxation by activating TRPV4 channels in rat mesenteric arteries. Eur J Pharmacol. 2019;859:172561.
CAS PubMed Article Google Scholar
Meduru H, Wang YT, Tsai JJ, Chen YC. Finding a potential dipeptidyl peptidase-4 (DPP-4) inhibitor for type-2 diabetes treatment based on molecular docking, pharmacophore generation, and molecular dynamics simulation. Int J Mol Sci. 2016;17:920.
PubMed Central Article CAS Google Scholar
Tang H, Wang H, Lin Q, Fan F, Zhang F, Peng X, et al. Loss of IP3 receptor-mediated Ca(2+) release in mouse B cells results in abnormal B cell development and function. J Immunol. 2017;199:570–80.
CAS PubMed Article Google Scholar
Zhang P, Sun C, Li H, Tang C, Kan H, Yang Z, et al. TRPV4 (Transient Receptor Potential Vanilloid 4) mediates endothelium-dependent contractions in the aortas of hypertensive mice. Hypertension. 2018;71:134–42.
CAS PubMed Article Google Scholar
Khaldan A, Bouamrane S, En-Nahli F, El-Mernissi R, El Khatabi K, Hmamouchi R, et al. Prediction of potential inhibitors of SARS-CoV-2 using 3D-QSAR, molecular docking modeling and ADMET properties. Heliyon 2021;7:e06603.
PubMed PubMed Central Article CAS Google Scholar
Takahashi N, Hamada-Nakahara S, Itoh Y, Takemura K, Shimada A, Ueda Y, et al. TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P(2). Nat Commun. 2014;5:4994.
CAS PubMed Article Google Scholar
Inada H, Procko E, Sotomayor M, Gaudet R. Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 2012;51:6195–206.
CAS PubMed Article Google Scholar
Kren V. Chirality matters: biological activity of optically pure silybin and its congeners. Int J Mol Sci. 2021;22:7885.
CAS PubMed PubMed Central Article Google Scholar
Xie Y, Zhang D, Zhang J, Yuan J. Metabolism, transport and drug-drug interactions of silymarin. Molecules. 2019;24:3693.
CAS PubMed Central Article Google Scholar
Aghazadeh S, Amini R, Yazdanparast R, Ghaffari SH. Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis. Exp Toxicol Pathol. 2011;63:569–74.
Cacciapuoti F, Scognamiglio A, Palumbo R, Forte R, Cacciapuoti F. Silymarin in non alcoholic fatty liver disease. World J Hepatol. 2013;5:109–13.
PubMed PubMed Central Article Google Scholar
Marino Z, Crespo G, D’Amato M, Brambilla N, Giacovelli G, Rovati L, et al. Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period. J Hepatol. 2013;58:415–20.
CAS PubMed Article Google Scholar
Abenavoli L, Izzo AA, Milic N, Cicala C, Santini A, Capasso R. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother Res. 2018;32:2202–13.
Pignatelli P, Carnevale R, Menichelli D. Silybin and metabolic disorders. Intern Emerg Med. 2019;14:1–3.
Hajiaghamohammadi AA, Ziaee A, Oveisi S, Masroor H. Effects of metformin, pioglitazone, and silymarin treatment on non-alcoholic Fatty liver disease: a randomized controlled pilot study. Hepat Mon. 2012;12:e6099.
PubMed PubMed Central Article Google Scholar
Yao J, Zhi M, Gao X, Hu P, Li C, Yang X. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver. Braz J Med Biol Res. 2013;46:270–7.
PubMed PubMed Central Article CAS Google Scholar
Wah Kheong C, Nik Mustapha NR, Mahadeva S. A randomized trial of silymarin for the treatment of nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2017;15:1940–9 e1948.
PubMed Article CAS Google Scholar
Grace MS, Bonvini SJ, Belvisi MG, McIntyre P. Modulation of the TRPV4 ion channel as a therapeutic target for disease. Pharmacol Ther. 2017;177:9–22.
CAS PubMed Article Google Scholar
Zhang T, Kawaguchi N, Yoshihara K, Hayama E, Furutani Y, Kawaguchi K, et al. Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia. Respir Res. 2019;20:79.
PubMed PubMed Central Article Google Scholar
Perticone F, Sciacqua A, Maio R, Perticone M, Maas R, Boger RH, et al. Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension. J Am Coll Cardiol. 2005;46:518–23.
CAS PubMed Article Google Scholar
Yao J, Zhi M, Minhu C. Effect of silybin on high-fat-induced fatty liver in rats. Braz J Med Biol Res. 2011;44:652–9.
Sun YH, Zhao J, Jin HT, Cao Y, Ming T, Zhang LL, et al. Vasorelaxant effects of the extracts and some flavonoids from the buds of Coreopsis tinctoria. Pharm Biol. 2013;51:1158–64.
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