Silybin induces endothelium-dependent vasodilation via TRPV4 channels in mouse mesenteric arteries

Bunchorntavakul C, Reddy KR. Review article: herbal and dietary supplement hepatotoxicity. Aliment Pharmacol Ther. 2013;37:3–17.

CAS  PubMed  Article  Google Scholar 

Federico A, Dallio M, Loguercio C. Silymarin/Silybin and chronic liver disease: a marriage of many years. Molecules. 2017;22:191.

PubMed Central  Article  CAS  Google Scholar 

Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. World J Gastroenterol. 2011;17:2288–301.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Janeczko M, Kochanowicz E. Silymarin, a popular dietary supplement shows anti-candida activity. Antibiotics. 2019;8:206.

CAS  PubMed Central  Article  Google Scholar 

Li Volti G, Salomone S, Sorrenti V, Mangiameli A, Urso V, Siarkos I, et al. Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice. Cardiovasc Diabetol. 2011;10:62.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sciacqua A, Perticone M, Tripepi G, Addesi D, Cassano V, Maio R, et al. Metabolic and vascular effects of silybin in hypertensive patients with high 1-h post-load plasma glucose. Intern Emerg Med. 2019;14:77–84.

PubMed  Article  Google Scholar 

Li X, Lin Y, Zhou H, Li Y, Wang A, Wang H, et al. Puerarin protects against endothelial dysfunction and end-organ damage in Ang II-induced hypertension. Clin Exp Hypertens. 2017;39:58–64.

PubMed  Article  CAS  Google Scholar 

Gonzalez J, Valls N, Brito R, Rodrigo R. Essential hypertension and oxidative stress: new insights. World J Cardiol. 2014;6:353–66.

PubMed  PubMed Central  Article  Google Scholar 

Konukoglu D, Uzun H. Endothelial dysfunction and hypertension. Adv Exp Med Biol. 2017;956:511–40.

PubMed  Article  Google Scholar 

Heathcote HR, Lee MD, Zhang X, Saunter CD, Wilson C, McCarron JG. Endothelial TRPV4 channels modulate vascular tone by Ca2+-induced Ca2+ release at inositol 1,4,5-trisphosphate receptors. Br J Pharmacol. 2019;176:3297–317.

CAS  PubMed  PubMed Central  Google Scholar 

Filosa JA, Yao X, Rath G. TRPV4 and the regulation of vascular tone. J Cardiovasc Pharmacol. 2013;61:113–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chen YL, Sonkusare SK. Endothelial TRPV4 channels and vasodilator reactivity. Curr Top Membr. 2020;85:89–117.

CAS  PubMed  Article  Google Scholar 

O’Neil RG, Heller S. The mechanosensitive nature of TRPV channels. Pflug Arch. 2005;451:193–203.

Article  CAS  Google Scholar 

Cao S, Anishkin A, Zinkevich NS, Nishijima Y, Korishettar A, Wang Z, et al. Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation. J Biol Chem. 2018;293:5307–22.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Liu L, Guo M, Lv X, Wang Z, Yang J, Li Y, et al. Role of transient receptor potential vanilloid 4 in vascular function. Front Mol Biosci. 2021;8:677661.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhou T, Wang Z, Guo M, Zhang K, Geng L, Mao A, et al. Puerarin induces mouse mesenteric vasodilation and ameliorates hypertension involving endothelial TRPV4 channels. Food Funct. 2020;11:10137–48.

CAS  PubMed  Article  Google Scholar 

Shao J, Han J, Zhu Y, Mao A, Wang Z, Zhang K, et al. Curcumin induces endothelium-dependent relaxation by activating endothelial TRPV4 channels. J Cardiovasc Transl Res. 2019;12:600–7.

PubMed  Article  Google Scholar 

Zhang X, Mao A, Xiao W, Zhang P, Han X, Zhou T, et al. Morin induces endothelium-dependent relaxation by activating TRPV4 channels in rat mesenteric arteries. Eur J Pharmacol. 2019;859:172561.

CAS  PubMed  Article  Google Scholar 

Meduru H, Wang YT, Tsai JJ, Chen YC. Finding a potential dipeptidyl peptidase-4 (DPP-4) inhibitor for type-2 diabetes treatment based on molecular docking, pharmacophore generation, and molecular dynamics simulation. Int J Mol Sci. 2016;17:920.

PubMed Central  Article  CAS  Google Scholar 

Tang H, Wang H, Lin Q, Fan F, Zhang F, Peng X, et al. Loss of IP3 receptor-mediated Ca(2+) release in mouse B cells results in abnormal B cell development and function. J Immunol. 2017;199:570–80.

CAS  PubMed  Article  Google Scholar 

Zhang P, Sun C, Li H, Tang C, Kan H, Yang Z, et al. TRPV4 (Transient Receptor Potential Vanilloid 4) mediates endothelium-dependent contractions in the aortas of hypertensive mice. Hypertension. 2018;71:134–42.

CAS  PubMed  Article  Google Scholar 

Khaldan A, Bouamrane S, En-Nahli F, El-Mernissi R, El Khatabi K, Hmamouchi R, et al. Prediction of potential inhibitors of SARS-CoV-2 using 3D-QSAR, molecular docking modeling and ADMET properties. Heliyon 2021;7:e06603.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Takahashi N, Hamada-Nakahara S, Itoh Y, Takemura K, Shimada A, Ueda Y, et al. TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P(2). Nat Commun. 2014;5:4994.

CAS  PubMed  Article  Google Scholar 

Inada H, Procko E, Sotomayor M, Gaudet R. Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 2012;51:6195–206.

CAS  PubMed  Article  Google Scholar 

Kren V. Chirality matters: biological activity of optically pure silybin and its congeners. Int J Mol Sci. 2021;22:7885.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Xie Y, Zhang D, Zhang J, Yuan J. Metabolism, transport and drug-drug interactions of silymarin. Molecules. 2019;24:3693.

CAS  PubMed Central  Article  Google Scholar 

Aghazadeh S, Amini R, Yazdanparast R, Ghaffari SH. Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis. Exp Toxicol Pathol. 2011;63:569–74.

PubMed  Article  Google Scholar 

Cacciapuoti F, Scognamiglio A, Palumbo R, Forte R, Cacciapuoti F. Silymarin in non alcoholic fatty liver disease. World J Hepatol. 2013;5:109–13.

PubMed  PubMed Central  Article  Google Scholar 

Marino Z, Crespo G, D’Amato M, Brambilla N, Giacovelli G, Rovati L, et al. Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period. J Hepatol. 2013;58:415–20.

CAS  PubMed  Article  Google Scholar 

Abenavoli L, Izzo AA, Milic N, Cicala C, Santini A, Capasso R. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother Res. 2018;32:2202–13.

PubMed  Article  Google Scholar 

Pignatelli P, Carnevale R, Menichelli D. Silybin and metabolic disorders. Intern Emerg Med. 2019;14:1–3.

PubMed  Article  Google Scholar 

Hajiaghamohammadi AA, Ziaee A, Oveisi S, Masroor H. Effects of metformin, pioglitazone, and silymarin treatment on non-alcoholic Fatty liver disease: a randomized controlled pilot study. Hepat Mon. 2012;12:e6099.

PubMed  PubMed Central  Article  Google Scholar 

Yao J, Zhi M, Gao X, Hu P, Li C, Yang X. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver. Braz J Med Biol Res. 2013;46:270–7.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Wah Kheong C, Nik Mustapha NR, Mahadeva S. A randomized trial of silymarin for the treatment of nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2017;15:1940–9 e1948.

PubMed  Article  CAS  Google Scholar 

Grace MS, Bonvini SJ, Belvisi MG, McIntyre P. Modulation of the TRPV4 ion channel as a therapeutic target for disease. Pharmacol Ther. 2017;177:9–22.

CAS  PubMed  Article  Google Scholar 

Zhang T, Kawaguchi N, Yoshihara K, Hayama E, Furutani Y, Kawaguchi K, et al. Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia. Respir Res. 2019;20:79.

PubMed  PubMed Central  Article  Google Scholar 

Perticone F, Sciacqua A, Maio R, Perticone M, Maas R, Boger RH, et al. Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension. J Am Coll Cardiol. 2005;46:518–23.

CAS  PubMed  Article  Google Scholar 

Yao J, Zhi M, Minhu C. Effect of silybin on high-fat-induced fatty liver in rats. Braz J Med Biol Res. 2011;44:652–9.

CAS  PubMed  Google Scholar 

Sun YH, Zhao J, Jin HT, Cao Y, Ming T, Zhang LL, et al. Vasorelaxant effects of the extracts and some flavonoids from the buds of Coreopsis tinctoria. Pharm Biol. 2013;51:1158–64.

CAS 

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