Yao-Chun Hsu has received research support from Gilead Sciences and has served as an advisory board member or consultant for Gilead Sciences, and has served as a speaker for Abbvie, Bristol-Myers Squibb, Gilead Sciences, Merck Sharp & Dohme, and Novartis. Grace Lai-Hung Wong has received research funding from Gilead Sciences and has served as an advisory board member or consultant for Gilead Sciences and Janssen, and has served as a speaker for Abbott, Abbvie, Bristol-Myers Squibb, Echosens, Furui, Gilead Sciences, Janssen and Roche. Cheng-Yuan Peng has served as an advisory board member or consultant for Abbvie, Bristol-Myers Squibb, Gilead Sciences, and Roche. Sebastian Marciano has received research or educational support from, Gilead Sciences, Bristol-Myers and Abbvie. Adrián Gadano has received research or educational support from, Gilead Sciences, Bristol-Myers and Abbvie. Hidenori Toyoda has served as a speaker for Gilead, AbbVie, Bayer, Eisai, Terumo, and Otsuka Pharmaceuticals. Seng Gee Lim has received educational or research funding from Abbott, Merck Sharpe and Dohme, Gilead Sciences, has served as an advisory board member for Gilead Sciences, Merck Sharpe and Dohme, Abbvie, and Abbott, and has served as a speaker for Gilead Sciences, Abbott, Merck Sharpe and Dohme, Roche. Mar Riveiro-Barciela has received research support from Gilead and has served as a speaker for Grifols. Dong Hyun Lee has received research support from Gilead Sciences Korea, Korea Pharma, and Jassen Korea. Jee Fu Huang has served as an advisory board member or consultant for Gilead Sciences and Abbvie, and has served as a speaker for Gilead Sciences, Abbvie, Bristol-Myers-Squibb, Merck Sharp & Dohme, Roche, and Sysmex. Chia-Yen Dai has served as an advisory board member or consultant for Abbvie and Gilead Sciences, and has served as a speaker for Abbvie, Bristol-Myers Squibb, Gilead Sciences, and Merck Sharp & Dohme. Wan-Long Chuang has served as a consultant for Abbvie, Bristol-Myers Squibb, Gilead Sciences, and Merck Sharp & Dohme, PharmaEssentia, and has served as a speaker for Abbvie, Bristol-Myers Squibb, Gilead Sciences, and Merck Sharp & Dohme, PharmaEssentia. Man-Fung Yuen has served as a consultant for AbbVie, Arbutus Biopharma, Assembly Biosciences, Bristol Myer Squibb, Dicerna Pharmaceuticals, GlaxoSmithKline, Gilead Sciences, Janssen, Merck Sharp and Dohme, Clear B Therapeutics, Springbank Pharmaceutical. Vincent Wai-Sun Wong has received research support from Gilead Sciences and has served as an advisory board member or consultant for 3 V-BIO, AbbVie, Allergan, Boehringer Ingelheim, Echosens, Gilead Sciences, Hanmi Pharmaceutical, Intercept, Merck, Novartis, Novo Nordisk, Perspectum Diagnostics, Pfizer, ProSciento, Sagimet Biosciences, TARGET PharmaSolutions, and Terns, and has served as a speaker for AbbVie, Bristol-Myers Squibb, Echosens, and Gilead Sciences. Maria Buti has received research support from Abbvie and Gilead Sciences, and has served as an advisory board member or consultant for Abbvie, Arbutus, Gilead, Janssen and Spring Bank. Ming-Lung Yu has received research grant from Abbott, BMS, Gilead and Merck and has served as a consultant for Abbvie, Abbott, Ascletis, BMS, Gilead, Merck and Roche, and a speaker of Abbvie, Abbott, BMS, Gilead, Merck, and IPSEN. Mindie H. Nguyen has received research support from Pfizer, Gilead Sciences, Enanta, Vir Biotech, Glycotests, B. K. Kee Foundation and the National Cancer Institute and has served as an advisory board member or consultant for Gilead, Intercept, Novartis, Eisai, Bayer, Exact Science, Laboratory of Advanced Medicine, Sprin Bank, and Janssen. Conduction of this study conformed to the ethics principles of the Declaration of Helsinki in 1975, as revised in 2008, and was approved by the Institutional Review Board of Stanford University (protocol number 13927) as well as at each site.