Author notes

S. Lagger and L. Kenner are co-last authors.

Authors and Affiliations

Department of Pathology, Medical University of Vienna, 1090, Vienna, Austria

I. Garces de los Fayos Alonso, L. Zujo, I. Wiest, M. Zrimšek, C. Giordano, M. Kothmayer, M. Schlederer, T. Limberger, C. Probst, O. Merkel, A. I. Schiefer, G. Egger & L. Kenner

Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria

I. Garces de los Fayos Alonso, L. Zujo, I. Wiest, P. Kodajova, M. Kothmayer, B. S. Schmalzbauer, C. Probst, S. Högler, S. Tangermann, S. Lagger & L. Kenner

Division of Nuclear Medicine, Medical University of Vienna, 1090, Vienna, Austria

L. Zujo, I. Wiest, T. Limberger, C. Probst & L. Kenner

Center for Cancer Research, Medical University of Vienna, 1090, Vienna, Austria

G. Timelthaler

Division Pharmacology, Department of Pharmacology, Physiology and Microbiology, Karl Landsteiner University of Health Sciences, 3500, Krems, Austria

S. Edtmayer & D. Stoiber

Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria

S. Kollmann & B. S. Schmalzbauer

Centre for Anatomy and Cell Biology, Medical University of Vienna, 1090, Vienna, Austria

M. Kothmayer & O. Pusch

Institute of Animal Breeding and Genetics, Unit of Functional Cancer Genomics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria

H. A. Neubauer & R. Moriggl

Department of Dermatology, Medical University of Graz, 8036, Graz, Austria

S. Dey & P. Wolf

Center for Medical Research (ZMF), Medical University of Graz, 8010, Graz, Austria

S. Dey & L. Kenner

CBMed Core Lab, Medical University of Vienna, 1090, Vienna, Austria

T. Limberger & L. Kenner

Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090, Vienna, Austria

C. Kornauth & P. B. Staber

Comprehensive Cancer Center Vienna, Vienna General Hospital, Medical University of Vienna, 1090, Vienna, Austria

C. Kornauth, P. B. Staber & G. Egger

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

N. Prutsch, M. Zimmerman & T. A. Look

Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

B. Abraham

Institute of Pathology, University of Wuerzburg, 97080, Würzburg, Germany

J. Anagnostopoulos

Institute of Pathology, Charité-Medical University of Berlin, 10117, Berlin, Germany

J. Anagnostopoulos

Institute of Pathology and Neuropathology and Cluster of excellence iFIT, “Image-Guided and Functionally Instructed Tumor Therapy”, University of Tübingen, 72076, Tübingen, Germany

L. Quintanilla-Martinez

Department of Hematology, Oncology, and Cancer Immunology, Charité-Medical University of Berlin, 12200, Berlin, Germany

S. Mathas

German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany

S. Mathas

Max-Delbrück-Center (MDC) for Molecular Medicine, 13125, Berlin, Germany

S. Mathas

Experimental and Clinical Research Center, a joint cooperation between the Charité and the MDC, 13125, Berlin, Germany

S. Mathas

Boltzmann Institute Applied Diagnostics, 1090, Vienna, Austria

G. Egger

Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel/University Hospital Schleswig-Holstein, 24105, Kiel, Germany

W. Klapper

Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany

W. Woessmann

Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, ON, L5L 1C6, Canada

P. Gunning

Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada

P. Gunning

Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, CB20QQ, UK

S. D. Turner

Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic

S. D. Turner

Christian Doppler Laboratory of Applied Metabolomics, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, 1090, Vienna, Austria

L. Kenner

Contributions

Conceptualization: IG, SL, LK. Funding acquisition: LK, SDT, OM. Formal analysis: IG, LZ, IW, PK, SE, CG, MZ, SK, GT, MK, HAN, SD, MS, BSS, TL, CP, OP, SH, ST, OM, AIS, CK, NP, MZ, BA, JA, LQM, SM, PW, DS, PBS, GE, WK, WW, TAL, PG, SDT, RM, SL, LK. Investigation: IG, LZ, IW, PK, MS, GT, SE, CG, MK, HAN, SD, BSS, SK, TL, MZ, MZi, NP, CP, OP, SH, ST, OM, AIS, CK, GE, LQM, WW, SDT, RM, SL, LK. Methodology: IG, PK, MS, GT, SE, OP, ST, SH, AIS, CK, TAL, BA, MZi. Project administration: IG, SL, LK. Resources: GT, HAN, SD, OP, SH, ST, OM, AIS, CK, PW, DS, PS, GE, JA, LQM, SM, WK, WW, ATL, PG, SDT, RM, SL, LK. Supervision: LK, SL. Validation and Visualization: IG. Writing – original draft: IG. Writing – review & editing: All. The author(s) read and approved the final manuscript.

Authors’ information

MRes Ines Garces de los Fayos Alonso: This work is part of her PhD thesis at Medical University of Vienna (MUV), which was done at Department of Experimental and Laboratory Animal Pathology (MUV) and at the Unit of Laboratory Animal Pathology, University of Veterinary Medicine (VetMedUni), Vienna, Austria.

BSc. Lamija Zujo: Master Student at the at the Department of Experimental and Laboratory Animal Pathology, MUV, Vienna, Austria.

BSc. Ivana Wiest: Master Student at the Division of Nuclear Medicine, MUV, Vienna, Austria.

MSc. Petra Kodajova: BMA at the Unit of Laboratory Animal Pathology, VetMedUni, Vienna, Austria.

Mag. Gerald Timelthaler: BMA at the Center for Cancer Research, MUV, Vienna, Austria.

MSc. Sophie Edtmayer: PhD Student at the Division Pharmacology, Department of Pharmacology, Physiology and Microbiology, Karl Landsteiner University of Health Sciences, Krems, Austria.

MSc. Masa Zrimsek: PhD Student at the Department of Pathology, MUV, Vienna, Austria.

Dr. Sebastian Kollmann (PhD): PostDoc at the Institute of Pharmacology and Toxicology, VetMedUni, Vienna, Austria.

MSc. Catello Giordano: PhD Student at the Department of Pathology, MUV, Vienna, Austria.

MSc. Michael Kothmayer: BMA at the Centre for Anatomy and Cell Biology, MUV, Vienna, Austria.

Dr. Heidi A. Neubauer (PhD): PostDoc at the Institute of Animal Breeding and Genetics, VetMedUni, Vienna, Austria.

MSc. Saptaswa Dey: PhD Student at the Department of Dermatology, Medical University of Graz, Graz, Austria.

MSc. Michaela Schlederer: BMA at the Department of Experimental and Laboratory Animal Pathology, MUV, Vienna, Austria.

MSc. Belinda S. Schmalzbauer: PhD student at Institute of Pharmacology and Toxicology, VetMedUni, Vienna, Austria.

DI. Tanja Limberger: PhD Student at the Department of Experimental and Laboratory Animal Pathology, MUV, Vienna, Austria.

BSc. Clara Probst: Master student at the Unit of Laboratory Animal Pathology, VetMedUni, Vienna, Austria.

Prof Dr. Oliver Pusch (PhD): Professor at the Centre for Anatomy and Cell Biology, MUV, Vienna, Austria.

Dr. Sandra Högler (DVM): Veterinary Pathologist at the Unit of Laboratory Animal Pathology, VetMedUni, Vienna, Austria.

Dr. Simone Tangermann (DVM): Veterinary Pathologist at the Unit of Laboratory Animal Pathology, VetMedUni, Vienna, Austria.

Assoc. Prof. Dr. Olaf Merkel (PhD): Associate Prof. at the Department of Pathology, MUV, Vienna, Austria.

Assoc. Prof. Dr. Ana-Iris Schiefer (PhD): Associate Prof. at the Department of Pathology, MUV, Vienna, Austria.

Dr. Christoph Kornauth (MD): PostDoc at the Department of Medicine I, Division of Hematology and Hemostaseology, MUV, Vienna, Austria.

Dr. Nicole Prutsch (PhD): PostDoc at the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Dr. Mark Zimmerman (PhD): PostDoc at the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Dr. Brian Abraham (PhD): PostDoc at the Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis TN, USA.

Prof. Dr. Ioannis Anagnostopoulos (MD): Professor at the Institute of Pathology, University of Wuerzburg, Germany.

Prof. Dr. Leticia Quintanilla-Martinez (MD): Professor at the Institute of Pathology and Neuropathology and Cluster of excellence iFIT, “Image-Guided and Functionally Instructed Tumor Therapy”, University of Tübingen, Germany.

Prof. Dr. Stephan Mathas (MD): Professor at the Department of Hematology, Oncology, and Cancer Immunology, Charité-Medical University of Berlin, Germany.

Prof. Dr. Peter Wolf (MD): Professor at the Department of Dermatology, Medical University of Graz, Graz, Austria.

Prof. Dr. Dagmar Stoiber (PhD): Professor at the Division Pharmacology, Department of Pharmacology, Physiology and Microbiology, Karl Landsteiner University of Health Sciences, Krems, Austria.

Prof. Dr. Phillip B. Staber (MD): Professor at the Department of Medicine I, Division of Hematology and Hemostaseology, MUV, Vienna, Austria.

Prof. Dr. Gerda Egger (PhD): Professor at the Department of Pathology, MUV, Vienna, Austria.

Prof. Dr. Wolfram Klapper (MD): Professor at the Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel/University Hospital Schleswig-Holstein, Germany.

Prof. Dr. Wilhelm Woessmann (MD): Professor at the Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Prof. Dr. Thomas A. Look (PhD): Professor at the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Prof. Dr. Patrick Gunning (PhD): Professor at the Department of Chemical and Physical Sciences, University of Toronto Mississauga, Canada.

Prof Dr. Suzanne D. Turner (PhD): Professor at the Department of Pathology, University Cambridge, UK.

Prof Dr. Richard Moriggl (PhD): Professor at the Institute of Animal Breeding and Genetics, VetMedUni, Vienna, Austria.

Dr. Sabine Lagger (PhD): PostDoc at the Unit of Laboratory Animal Pathology, VetMedUni, Vienna, Austria.

Prof. Dr. Lukas Kenner (MD): Clinical and Laboratory Animal Pathologist, Head of The Department of Experimental and Laboratory Animal Pathology, MUV and of the Unit of Laboratory Animal Pathology, VetMedUni, Vienna, Austria.

Corresponding author

Correspondence to L. Kenner.