Fuster V, Voûte J. MDGs: chronic diseases are not on the agenda. Lancet. 2005;366(9496):1512–4. https://doi.org/10.1016/S0140-6736(05)67610-6.

Article  PubMed  Google Scholar 

Coebergh JW, Janssen-Heijnen ML, Post PN, Razenberg PP. Serious co-morbidity among unselected cancer patients newly diagnosed in the southeastern part of The Netherlands in 1993–1996. J Clin Epidemiol. 1999;52(12):1131–6. https://doi.org/10.1016/s0895-4356(99)00098-0.

CAS  Article  PubMed  Google Scholar 

Tapia-Vieyra JV, Delgado-Coello B, Mas-Oliva J. Atherosclerosis and Cancer; a resemblance with far-reaching implications. Arch Med Res. 2017;48(1):12–26. https://doi.org/10.1016/j.arcmed.2017.03.005.

CAS  Article  PubMed  Google Scholar 

Koene RJ, Prizment AE, Blaes A, Konety SH. Shared risk factors in cardiovascular disease and cancer. Circulation. 2016;133(11):1104–14. https://doi.org/10.1161/CIRCULATIONAHA.115.020406.

Article  PubMed  PubMed Central  Google Scholar 

Wingo PA, Ries LA, Rosenberg HM, Miller DS, Edwards BK. Cancer incidence and mortality, 1973–1995: a report card for the U.S. Cancer. 1998;82(6):1197–207. https://doi.org/10.1002/(sici)1097-0142(19980315)82:6%3c1197::aid-cncr26%3e3.0.co;2-0.

CAS  Article  PubMed  Google Scholar 

Benditt EP, Benditt JM. Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci USA. 1973;70(6):1753–6. https://doi.org/10.1073/pnas.70.6.1753.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Botto N, Rizza A, Colombo MG, et al. Evidence for DNA damage in patients with coronary artery disease. Mutat Res. 2001;493(1–2):23–30. https://doi.org/10.1016/s1383-5718(01)00162-0.

CAS  Article  PubMed  Google Scholar 

Neugut AI, Rosenberg DJ, Ahsan H, et al. Association between coronary heart disease and cancers of the breast, prostate, and colon. Cancer Epidemiol Biomarkers Prev. 1998;7(10):869–73.

CAS  PubMed  Google Scholar 

Vinkhuyzen AA, Wray NR, Yang J, Goddard ME, Visscher PM. Estimation and partition of heritability in human populations using whole-genome analysis methods. Annu Rev Genet. 2013;47:75–95. https://doi.org/10.1146/annurev-genet-111212-133258.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Schunkert H, König IR, Kathiresan S, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011;43(4):333–8. https://doi.org/10.1038/ng.784.

CAS  Article  PubMed  PubMed Central  Google Scholar 

McPherson R, Pertsemlidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316(5830):1488–91. https://doi.org/10.1126/science.1142447.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Helgadottir A, Thorleifsson G, Manolescu A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007;316(5830):1491–3. https://doi.org/10.1126/science.1142842.

CAS  Article  PubMed  Google Scholar 

Samani NJ, Erdmann J, Hall AS, et al. Genomewide association analysis of coronary artery disease. N Engl J Med. 2007;357(5):443–53. https://doi.org/10.1056/NEJMoa072366.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Roberts R. Genetics of coronary artery disease: an update. Methodist Debakey Cardiovasc J. 2014;10(1):7–12. https://doi.org/10.14797/mdcj-10-1-7.

Article  PubMed  PubMed Central  Google Scholar 

Jarinova O, Stewart AF, Roberts R, et al. Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler Thromb Vasc Biol. 2009;29(10):1671–7. https://doi.org/10.1161/ATVBAHA.109.189522.

CAS  Article  PubMed  Google Scholar 

Holdt LM, Beutner F, Scholz M, et al. ANRIL expression is associated with atherosclerosis risk at chromosome 9p21. Arterioscler Thromb Vasc Biol. 2010;30(3):620–7. https://doi.org/10.1161/ATVBAHA.109.196832.

CAS  Article  PubMed  Google Scholar 

McPherson R, Tybjaerg-Hansen A. Genetics of coronary artery disease. Circ Res. 2016;118(4):564–78. https://doi.org/10.1161/CIRCRESAHA.115.306566.

CAS  Article  PubMed  Google Scholar 

van der Harst P, Verweij N. Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease. Circ Res. 2018;122(3):433–43. https://doi.org/10.1161/CIRCRESAHA.117.312086.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Spracklen CN, Chen P, Kim YJ, et al. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Hum Mol Genet. 2017;26(9):1770–84. https://doi.org/10.1093/hmg/ddx062l.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Turner AW, Wong D, Dreisbach CN, Miller CL. GWAS reveal targets in vessel wall pathways to treat coronary artery disease. Front Cardiovasc Med. 2018;5:72. https://doi.org/10.3389/fcvm.2018.00072.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Mani A, Radhakrishnan J, Wang H, et al. LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science. 2007;315(5816):1278–82. https://doi.org/10.1126/science.1136370.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Keramati AR, Fathzadeh M, Go GW, et al. A form of the metabolic syndrome associated with mutations in DYRK1B. N Engl J Med. 2014;370(20):1909–19. https://doi.org/10.1056/NEJMoa1301824.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Khera AV, Kathiresan S. Genetics of coronary artery disease: discovery, biology and clinical translation. Nat Rev Genet. 2017;18(6):331–44. https://doi.org/10.1038/nrg.2016.160.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Funalot B, Varenne O, Mas JL. A call for accurate phenotype definition in the study of complex disorders. Nat Genet. 2004;36(1):3–4. https://doi.org/10.1038/ng0104-3a.

CAS  Article  PubMed  Google Scholar 

Li WQ, Pfeiffer RM, Hyland PL, et al. Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers. Carcinogenesis. 2014;35(12):2698–705. https://doi.org/10.1093/carcin/bgu203.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bishop DT, Demenais F, Iles MM, et al. Genome-wide association study identifies three loci associated with melanoma risk. Nat Genet. 2009;41(8):920–5. https://doi.org/10.1038/ng.411.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Amos CI, Wang LE, Lee JE, et al. Genome-wide association study identifies novel loci predisposing to cutaneous melanoma. Hum Mol Genet. 2011;20(24):5012–23. https://doi.org/10.1093/hmg/ddr415.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Stacey SN, Sulem P, Masson G, et al. New common variants affecting susceptibility to basal cell carcinoma. Nat Genet. 2009;41(8):909–14. https://doi.org/10.1038/ng.412.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Wrensch M, Jenkins RB, Chang JS, et al. Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet. 2009;41(8):905–8. https://doi.org/10.1038/ng.408.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Timofeeva MN, Hung RJ, Rafnar T, et al. Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. Hum Mol Genet. 2012;21(22):4980–95. https://doi.org/10.1093/hmg/dds334.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Turnbull C, Ahmed S, Morrison J, et al. Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet. 2010;42(6):504–7. https://doi.org/10.1038/ng.586.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Bei JX, Li Y, Jia WH, et al. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet. 2010;42(7):599–603. https://doi.org/10.1038/ng.601.

CAS  Article  PubMed  Google Scholar 

Osman W, Low SK, Takahashi A, Kubo M, Nakamura Y. A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. Hum Mol Genet. 2012;21(12):2836–42. https://doi.org/10.1093/hmg/dds103.

CAS  Article  PubMed  Google Scholar 

Gu F, Pfeiffer RM, Bhattacharjee S, et al. Common genetic variants in the 9p21 region and their associations with multiple tumours. Br J Cancer. 2013;108(6):1378–86. https://doi.org/10.1038/bjc.2013.7.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Yang XR, Lia