Exosomes carrying immune checkpoints, a promising therapeutic approach in cancer treatment

Dai J, Su Y, Zhong S, Cong L, Liu B, Yang J, et al. Exosomes: key players in cancer and potential therapeutic strategy. Signal Transduct Target Ther. 2020;5(1):145. https://doi.org/10.1038/s41392-020-00261-0.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Johnstone RM, Adam M, Hammond J, Orr L, Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 1987;262(19):9412–20.

CAS  PubMed  Article  Google Scholar 

Bahrami A, Moradi Binabaj MA, Ferns G. Exosomes: emerging modulators of signal transduction in colorectal cancer from molecular understanding to clinical application. Biomed Pharmacother. 2021;141:111882. https://doi.org/10.1016/j.biopha.2021.111882.

CAS  Article  PubMed  Google Scholar 

Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sun W, Ren Y, Lu Z, Zhao X. The potential roles of exosomes in pancreatic cancer initiation and metastasis. Mol Cancer. 2020;19(1):1–18.

Google Scholar 

Ahmadi M, Rezaie J. Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications. J Transl Med. 2020;18(1):1–17.

Article  CAS  Google Scholar 

Gluszko A, Mirza SM, Piszczatowska K, Kantor I, Struga M, Szczepanski MJ. The role of tumor-derived exosomes in tumor angiogenesis and tumor progression. Curr Issues Pharm Med Sci. 2019;32(4):193–202.

Article  Google Scholar 

Pan X, Zheng L. Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment. Cell Mol Immunol. 2020;17(9):940–53.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Olejarz W, Dominiak A, Żołnierzak A, Kubiak-Tomaszewska G, Lorenc T. Tumor-derived exosomes in immunosuppression and immunotherapy. J Immunol Res. 2020;2020:6272498. https://doi.org/10.1155/2020/6272498.

Xing C, Li H, Li R-J, Yin L, Zhang H-F, Huang Z-N, et al. The roles of exosomal immune checkpoint proteins in tumors. Mil Med Res. 2021;8(1):1–10.

Google Scholar 

Lawler SE, Nowicki MO, Ricklefs FL, Chiocca EA. Immune escape mediated by exosomal PD-L1 in cancer. Adv Biosyst. 2020;4(12):2000017.

CAS  Article  Google Scholar 

Shimizu A, Sawada K, Kobayashi M, Yamamoto M, Yagi T, Kinose Y, et al. Exosomal CD47 plays an essential role in immune evasion in ovarian cancer. Mol Cancer Res. 2021;19(9):1583–95.

CAS  PubMed  Article  Google Scholar 

You L, Wu W, Wang X, Fang L, Adam V, Nepovimova E, et al. The role of hypoxia-inducible factor 1 in tumor immune evasion. Med Res Rev. 2021;41(3):1622–43.

CAS  PubMed  Article  Google Scholar 

Spugnini EP, Logozzi M, Di Raimo R, Mizzoni D, Fais S. A role of tumor-released exosomes in paracrine dissemination and metastasis. Int J Mol Sci. 2018;19(12):3968.

PubMed Central  Article  Google Scholar 

Fu S, Wang Y, Xia X, Zheng JC. Exosome engineering: current progress in cargo loading and targeted delivery. NanoImpact. 2020;20:100261. https://doi.org/10.1016/j.impact.2020.100261.

Article  Google Scholar 

Gastpar R, Gehrmann M, Bausero MA, Asea A, Gross C, Schroeder JA, et al. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Can Res. 2005;65(12):5238–47.

CAS  Article  Google Scholar 

Taghikhani A, Farzaneh F, Sharifzad F, Mardpour S, Ebrahimi M, Hassan ZM. Engineered tumor-derived extracellular vesicles: potentials in cancer immunotherapy. Front Immunol. 2020. https://doi.org/10.3389/fimmu.2020.00221.

Article  PubMed  PubMed Central  Google Scholar 

Yen E-Y, Miaw S-C, Yu J-S, Lai IR. Exosomal TGF-β1 is correlated with lymphatic metastasis of gastric cancers. Am J Cancer Res. 2017;7(11):2199–208.

CAS  PubMed  PubMed Central  Google Scholar 

Iero M, Valenti R, Huber V, Filipazzi P, Parmiani G, Fais S, et al. Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ. 2008;15(1):80–8.

CAS  PubMed  Article  Google Scholar 

Hao Q, Wu Y, Wu Y, Wang P, Vadgama JV. Tumor-derived exosomes in tumor-induced immune suppression. Int J Mol Sci. 2022;23(3):1461.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lundholm M, Schröder M, Nagaeva O, Baranov V, Widmark A, Mincheva-Nilsson L, et al. Prostate tumor-derived exosomes down-regulate NKG2D expression on natural killer cells and CD8+ T cells: mechanism of immune evasion. PLoS ONE. 2014;9(9):e108925.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Mittelbrunn M, Gutiérrez-Vázquez C, Villarroya-Beltri C, González S, Sánchez-Cabo F, González MÁ, et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun. 2011;2(1):1–10.

Article  CAS  Google Scholar 

Shojaei S, Hashemi SM, Ghanbarian H, Salehi M, Mohammadi-Yeganeh S. Effect of mesenchymal stem cells-derived exosomes on tumor microenvironment: tumor progression versus tumor suppression. J Cell Physiol. 2019;234(4):3394–409.

CAS  PubMed  Article  Google Scholar 

Shen Y, Xue C, Li X, Ba L, Gu J, Sun Z, et al. Effects of gastric cancer cell-derived exosomes on the immune regulation of mesenchymal stem cells by the NF-kB signaling pathway. Stem Cells Dev. 2019;28(7):464–76.

CAS  PubMed  Article  Google Scholar 

Mulero MC, Huxford T, Ghosh G. NF-κB, IκB, and IKK: integral components of immune system signaling. Struct Immunol. 2019. https://doi.org/10.1007/978-981-13-9367-9_10.

Article  Google Scholar 

Mishra V, Pathak C. Human Toll-Like Receptor 4 (hTLR4): Structural and functional dynamics in cancer. Int J Biol Macromol. 2019;122:425–51.

CAS  PubMed  Article  Google Scholar 

Domenis R, Cifù A, Marinò D, Fabris M, Niazi KR, Soon-Shiong P, et al. Toll-Like receptor-4 activation boosts the immunosuppressive properties of tumor cells-derived exosomes. Sci Rep. 2019;9(1):1–14.

CAS  Article  Google Scholar 

Mirzaei R, Sarkar S, Dzikowski L, Rawji KS, Khan L, Faissner A, et al. Brain tumor-initiating cells export tenascin-C associated with exosomes to suppress T cell activity. Oxfordshire: Taylor & Francis; 2018. p. e1478647.

Google Scholar 

Bland CL, Byrne-Hoffman CN, Fernandez A, Rellick SL, Deng W, Klinke DJ. Exosomes derived from B16F0 melanoma cells alter the transcriptome of cytotoxic T cells that impacts mitochondrial respiration. FEBS J. 2018;285(6):1033–50.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wu Y, Deng W, McGinley EC, Klinke DJ. Melanoma exosomes deliver a complex biological payload that upregulates PTPN 11 to suppress T lymphocyte function. Pigment Cell Melanoma Res. 2017;30(2):203–18.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tung SL, Boardman DA, Sen M, Letizia M, Peng Q, Cianci N, et al. Regulatory T cell-derived extracellular vesicles modify dendritic cell function. Sci Rep. 2018;8(1):1–12.

Google Scholar 

Li L, Cao B, Liang X, Lu S, Luo H, Wang Z, et al. Microenvironmental oxygen pressure orchestrates an anti-and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes. Oncogene. 2019;38(15):2830–43.

CAS  PubMed  Article  Google Scholar 

Muntasell A, Berger AC, Roche PA. T cell-induced secretion of MHC class II–peptide complexes on B cell exosomes. EMBO J. 2007;26(19):4263–72.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol. 2007;8(3):239–45.

CAS  PubMed  Article  Google Scholar 

Lotfinejad P, Kazemi T, Mokhtarzadeh A, Shanehbandi D, Niaragh FJ, Safaei S, et al. PD-1/PD-L1 axis importance and tumor microenvironment immune cells. Life Sci. 2020;259:118297.

CAS  PubMed  Article  Google Scholar 

Tang Y, Zhang P, Wang Y, Wang J, Su M, Wang Y, et al. The biogenesis, biology, and clinical significance of exosomal PD-L1 in cancer. Front Immunol. 2020;11:604.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fan Y, Che X, Qu J, Hou K, Wen T, Li Z, et al. Exosomal PD-L1 retains immunosuppressive activity and is associated with gastric cancer prognosis. Ann Surg Oncol. 2019;26(11):3745–55.

PubMed  Article  Google Scholar 

Liang B, Hu X, Ding Y, Liu M. Tumor-derived exosomes in the PD-1/PD-L1 axis: Significant regulators as well as promising clinical targets. J Cell Physiol. 2021;236(6):4138–51.

CAS  PubMed  Article  Google Scholar 

Zhou K, Guo S, Li F, Sun Q, Liang G. Exosomal PD-L1: new insights into tumor immune escape mechanisms and therapeutic strategies. Front Cell Dev Biol. 2020. https://doi.org/10.3389/fcell.2020.569219.

Article  PubMed  PubMed Central  Google Scholar 

Ye L, Zhu Z, Chen X, Zhang H, Huang J, Gu S, et al. The Importance of exosomal PD-L1 in cancer progression and its potential as a therapeutic target. Cells. 2021;10(11):3247.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature. 2018;560(7718):382–6.

CAS  PubMed 

留言 (0)

沒有登入
gif