Cooper J, Giancotti FG. Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance. Cancer Cell. 2019;35(3):347–67.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hu Y-Z, Hu Z-L, Liao T-Y, et al. LncRNA SND1-IT1 facilitates TGF-β1-induced epithelial-to-mesenchymal transition via miR-124/COL4A1 axis in gastric cancer. Cell death discovery. 2022;8(1):1–12.

Google Scholar 

Liu K, Cheng L, Zhu K, et al. The cancer/testis antigen HORMAD1 mediates epithelial–mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway in lung cancer. Cell Death Discovery. 2022;8(1):1–14.

Google Scholar 

Hu Z, Artibani M, Alsaadi A, et al. The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells. Cancer Cell. 2020;37(2):226-242 e7.

CAS  PubMed  Article  Google Scholar 

Mortezaee K. Redox tolerance and metabolic reprogramming in solid tumors. Cell Biol Int. 2021;45(2):273–86.

CAS  PubMed  Article  Google Scholar 

Mortezaee K. Organ tropism in solid tumor metastasis: an updated review. Future Oncol. 2021. https://doi.org/10.1002/cbin.11506.

Article  PubMed  Google Scholar 

Bhattacharya A, Mukherjee S, Khan P, et al. SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin. Sci Signal. 2020;13(654):eaay6077.

CAS  PubMed  Article  Google Scholar 

Farhood B, Najafi M, Salehi E, et al. Disruption of the redox balance with either oxidative or anti-oxidative overloading as a promising target for cancer therapy. J Cell Biochem. 2019;120(1):71–6.

CAS  PubMed  Article  Google Scholar 

Mortezaee K, Majidpoor J. Key promoters of tumor hallmarks. Int J Clin Oncol. 2021;27:45–58.

PubMed  Article  CAS  Google Scholar 

Zou H, Yang Z, Chan Y-S, et al. Single cell analysis of mechanical properties and EMT-related gene expression profiles in cancer fingers. Iscience. 2022;25(3):103917.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Okita Y, Kimura M, Xie R, et al. The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB. Sci Signal. 2017;10(474):eaak9397.

PubMed  Article  CAS  Google Scholar 

Chang Y, Zhang J, Huo X, et al. Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction. Cell Rep. 2022;38(7):110390.

CAS  PubMed  Article  Google Scholar 

Majidpoor J, Mortezaee K. Steps in metastasis: an updated review. Med Oncol. 2021;38(1):1–17.

Article  Google Scholar 

Mortezaee K, Majidpoor J. (Im) maturity in tumor ecosystem. Front Oncol. 2021;11:813897–813897.

PubMed  Article  Google Scholar 

Chakraborty S, Mir KB, Seligson ND, et al. Integration of EMT and cellular survival instincts in reprogramming of programmed cell death to anastasis. Cancer Metastasis Rev. 2020. https://doi.org/10.1007/s10555-020-09866-x.

Article  PubMed  Google Scholar 

Cano A, Pérez-Moreno MA, Rodrigo I, et al. The transcription factor snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. 2000;2(2):76–83.

CAS  PubMed  Article  Google Scholar 

Chakrabarti R, Hwang J, Andres Blanco M, et al. Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol. 2012;14(11):1212–22.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Serresi M, Kertalli S, Li L, et al. Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition. Sci Adv. 2021;7(9):eabd7974.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wu L, Yu K, Chen K, et al. Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation. Cell Death Dis. 2022;13(3):1–12.

CAS  Article  Google Scholar 

Liu J, Zang Y, Ma C, et al. Pseudophosphatase STYX is induced by Helicobacter pylori and promotes gastric cancer progression by inhibiting FBXO31 function. Cell Death Dis. 2022;13(3):1–12.

Google Scholar 

Yao Y, Liu Z, Huang S, et al. The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway. Cell Death Discov. 2022;8(1):1–12.

Google Scholar 

Mortezaee K. Enriched cancer stem cells, dense stroma, and cold immunity: Interrelated events in pancreatic cancer. J Biochem Mol Toxicol. 2021;35(4):e22708.

CAS  PubMed  Article  Google Scholar 

Li Y, Hu J, Guo D, et al. LncRNA SNHG5 promotes the proliferation and cancer stem cell-like properties of HCC by regulating UPF1 and Wnt-signaling pathway. Cancer Gene Ther. 2022. https://doi.org/10.1038/s41417-022-00456-3.

Article  PubMed  PubMed Central  Google Scholar 

Hermann PC, Sainz B Jr. Pancreatic cancer stem cells: A state or an entity? in Seminars in cancer biology. Amsterdam: Elsevier; 2018.

Google Scholar 

Kim J, Park C, Kim KH, et al. Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity. NPJ Precis Oncol. 2022;6(1):1–11.

Article  CAS  Google Scholar 

Nicolas AM, Pesic M, Engel E, et al. Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. Cancer Cell. 2022;40(2):168-184 e13.

CAS  PubMed  Article  Google Scholar 

Najafi M, Mortezaee K, Majidpoor J. Stromal reprogramming: a target for tumor therapy. Life Sci. 2019;239:117049.

CAS  PubMed  Article  Google Scholar 

Boukouris AE, Zhang Y, Saleme B, et al. A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer. Cell Rep. 2022;38(11):110511.

CAS  PubMed  Article  Google Scholar 

Li H, Li J, Chen L, et al. HERC3-mediated SMAD7 ubiquitination degradation promotes autophagy-induced EMT and chemoresistance in glioblastoma. Clin Cancer Res. 2019;25(12):3602–16.

CAS  PubMed  Article  Google Scholar 

Wilson MM, Callens C, Le Gallo M, et al. An EMT–primary cilium–GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis. Sci Adv. 2021;7(44):eabf6063.

CAS  PubMed  PubMed Central  Article  Google Scholar 

García-Jiménez C, Goding CR. Starvation and pseudo-starvation as drivers of cancer metastasis through translation reprogramming. Cell Metab. 2019;29(2):254–67.

PubMed  Article  CAS  Google Scholar 

Liu M, Li H, Zhang H, et al. RBMS1 promotes gastric cancer metastasis through autocrine IL-6/JAK2/STAT3 signaling. Cell Death Dis. 2022;13(3):1–12.

Google Scholar 

Majidpoor J, Mortezaee K. Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications. Biomed Pharmacother. 2022;145:112419.

CAS  PubMed  Article  Google Scholar 

Li L, Li Z, Lu C, et al. Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling. Commun Biolo. 2022;5(1):1–14.

Article  Google Scholar 

Brodziak A, Sobczuk P, Bartnik E, et al. Drug resistance in papillary RCC: from putative mechanisms to clinical practicalities. Nat Rev Urol. 2019;16(11):655–73.

PubMed  Article  Google Scholar 

Qi M, Xia Y, Wu Y, et al. Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nat Commun. 2022;13(1):1–18.

Google Scholar 

Xia X, Zhang Z, Zhu C, et al. Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications. Nat Commun. 2022;13(1):1–14.

Google Scholar 

Stehr AM, Wang G, Demmler R, et al. Neutrophil extracellular traps drive epithelial–mesenchymal transition of human colon cancer. J Pathol. 2022;256(4):455–67.

CAS  PubMed  Article  Google Scholar 

Majidpoor J, Mortezaee K. The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives. Clin Immunol. 2021;226:108707.

CAS  PubMed  Article  Google Scholar 

Mortezaee K, Majidpoor J. Checkpoint inhibitor/interleukin-based combination therapy of cancer. Cancer Med. 2022. https://doi.org/10.1002/cam4.4659.

Article  PubMed  PubMed Central  Google Scholar 

Malta TM, Sokolov A, Gentles AJ, et al. Machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell. 2018;173(2):338-354 e15.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ricklefs FL, Alayo Q, Krenzlin H, et al. Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018;4(3):eaar2766.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Guo Y, Lu X, Chen Y, et al. Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells. Sci Adv. 2021;7(21):eabd7455.

CAS  PubMed  PubMed Central  Article