Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis

Keywords

Antibody

B cells

BLIMP1

IRF4

Malignancy

Multiple myeloma

Plasma cells

Transcriptional regulation

XBP1

AbbreviationsAICE

AP-1-IRF composite element

AID

activation-induced cytidine deaminase

ATF6

activating transcription factor 6

BACH2

BTB domain and CNC homolog 2

BATF

B cell activating transcription factor

BIM

Bcl-2 interacting mediator of cell death

BLIMP1

B lymphocyte-induced maturation protein 1

BMF

Bcl-2 modifying factor

BTK

Bruton's tyrosine kinase

bZIP

family which harbours basic leucine zipper

CREB/ATF

cAMP response element binding protein/activating transcription factor

CRISPR

Clustered regularly interspaced short palindromic repeats

CSR

class-switch recombination

CXCL12

C‐X‐C motif chemokine ligand 12

CXCR4

C-X-C chemokine receptor type 4

DNA-PKcs

DNA-dependent protein kinase catalytic subunit

DNAJB11

DnaJ homolog subfamily B member 11

EICE

Ets-IRF composite motifs

FDCs

follicular dendritic cells

H3K27

histone H3 lysine 27

IAD

interferon activation domain

ID3

DNA-binding protein inhibitor

IRE1α

inositol-requiring transmembrane kinase/endoribonuclease 1α

IRF4

interferon regulatory factor 4

ISRE

interferon-stimulated response element

KDM1A

lysine demethylase 1A

MGUS

monoclonal gammopathy of undetermined significance

mTORC1

mammalian target of rapamycin complex 1

MUM1

multiple myeloma oncogene 1

OBF-1

Oct binding factor 1

PRDI

positive regulatory domain I

RAG2

recombination-activating gene-2

RANKL

receptor activator of NF-κB ligand

ROS

reactive oxygen species

SMM

smouldering multiple myeloma

SYK

spleen tyrosine kinase

UPR

unfold protein response

XBP1

X box binding protein 1

ZICE

zinc finger-IRF composite elements

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