Liaw YF, Chu CM. Hepatitis B virus infection. Lancet. 2009;373:582–92.
CAS PubMed Article Google Scholar
Liaw YF. Clinical utility of HBV surface antigen quantification in HBV e antigen-negative chronic HBV infection. Nat Rev Gastroenterol Hepatol. 2019;16:631–41.
Sarin SK, Kumar M, Lau GK, et al. Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update. Hepatol Int. 2016;10:1–98.
CAS PubMed Article Google Scholar
Lampertico P, Agarwal K, Berg T, et al. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67:370–98.
Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67:1560–99.
Clermont RJ, Chalmers TC. The transaminase tests in liver disease. Medicine (Baltimore). 1967;46:197–207.
Prati D, Taioli E, Zanella A, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med. 2002;137:1–10.
CAS PubMed Article Google Scholar
Terrault NA, Bzowej NH, Chang KM, et al. AASLD guidelines for treatment of chronic hepatitis B. Hepatology. 2016;63:261–83.
Neuschwander-Tetri BA, Unalp A, Creer MH. Nonalcoholic steatohepatitis clinical research network. The upper limits of normal for serum ALT levels reported by clinical laboratories depend on local reference populations. Arch Intern Med. 2004. https://doi.org/10.1001/archinternmed.2007.131.
Article PubMed Central Google Scholar
Dutta A, Saha C, Johnson CS, Chalasani N. Variability in the upper limit of normal for serum alanine aminotransferase levels: a statewide study. Hepatology. 2009;50:1957–62.
CAS PubMed Article Google Scholar
Panteghini M, Adeli K, Ceriotti F, Sandberg S, Horvath AR. American liver guidelines and cutoffs for “Normal” ALT: a potential for overdiagnosis. Clin Chem. 2017;63:1196–8.
CAS PubMed Article Google Scholar
Hui CK, Leung N, Yuen ST, et al. Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phase. Hepatology. 2007;46:395–401.
Manno M, Cammà C, Schepis F, et al. Natural history of chronic HBV carriers in northern Italy: morbidity and mortality after 30 years. Gastroenterology. 2004;127:756–63.
Tai DI, Lin SM, Sheen IS, et al. Long-term outcome of hepatitis B e antigen-negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time. Hepatology. 2009;49:1859–67.
CAS PubMed Article Google Scholar
Brahmania M, Lombardero M, Hansen BE, et al. Association between severe serum alanine aminotransferase flares and hepatitis B e antigen seroconversion and HBV DNA decrease in untreated patients with chronic HBV infection. Clin Gastroenterol Hepatol. 2019;17:2541–51.
CAS PubMed PubMed Central Article Google Scholar
Liem KS, Fung S, Wong DK, et al. Limited sustained response after stopping nucleos(t)ide analogues in patients with chronic hepatitis B: results from a randomised controlled trial (toronto stop study). Gut. 2019;68:2206–13.
CAS PubMed Article Google Scholar
Chang ML, Liaw YF. Hepatitis B flares in chronic hepatitis B: pathogenesis, natural course and management. J Hepatol. 2014;61:1407–17.
Buti M, Gane E, Seto WK, Chan HL, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, Phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol. 2016;1:196–206.
Chu CM, Karayiannis P, Fowler MJF, Thomas HC, et al. Natural history of chronic hepatitis B virus infection in Taiwan: studies of hepatitis B virus DNA in serum. Hepatology. 1985;5:431–4.
CAS PubMed Article Google Scholar
Brunetto MR, Giarin MM, Oliveri F, et al. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci U S A. 1991;88:4186–90.
CAS PubMed PubMed Central Article Google Scholar
Kennedy PTF, Sandalova E, Jo J, et al. Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B. Gastroenterology. 2012;143:637–45.
CAS PubMed Article Google Scholar
Mason WS, Gill US, Litwin S, et al. HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant. Gastroenterology. 2016;151:986–98.
CAS PubMed Article Google Scholar
Milich DR. The concept of immune tolerance in chronic hepatitis B virus infection is alive and well. Gastroenterology. 2016;151:801–4.
Liaw YF, Chu CM. Immune tolerance phase of chronic hepatitis B. Gastroenterology. 2017;152:1245–6.
Schwartz RH. Historical overview of immunological tolerance. Cold Spring Harb Perspect Biol. 2012;4: a006908.
PubMed PubMed Central Article CAS Google Scholar
Jeng WJ, Lok AS. Should treatment indications for chronic hepatitis B be expanded? Clin Gastroenterol Hepatol. 2021;10:2006–14.
Lee HW, Chan HL. Unresolved issues of immune tolerance in chronic hepatitis B. J Gastroenterol. 2020;55:383–9.
PubMed PubMed Central Article Google Scholar
Lok AS, Perrillo R, Lalama CM, et al. Low incidence of adverse outcomes in adults with chronic hepatitis B virus infection in the era of antiviral therapy. Hepatology. 2021;73:2124–40.
CAS PubMed Article Google Scholar
Mason WS, Jilbert AR, Litwin S. Hepatitis B virus DNA integration and clonal expansion of hepatocytes in the chronically infected liver. Viruses. 2021;13:210.
CAS PubMed PubMed Central Article Google Scholar
World Health Organization; Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection. 2015. https://www.who.int/publications/i/item/9789241549059. Accessed 01 Dec 2021.
Gane EJ, Charlton MR, Mohamed R, et al. Asian consensus recommendations on optimizing the diagnosis and initiation of treatment of hepatitis B virus infection in resource-limited settings. J Viral Hepat. 2020;27:466–75.
Wu JF, Su YR, Chen CH, et al. Predictive effect of serial serum alanine aminotransferase levels on spontaneous HBeAg seroconversion in chronic genotype B and C HBV-infected children. J Pediatr Gastroenterol Nutr. 2012;54:97–100.
CAS PubMed PubMed Central Article Google Scholar
Chu CM, Hung SJ, Lin J, et al. Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels. Am J Med. 2004;116:829–34.
CAS PubMed Article Google Scholar
Lee HA, Lee HW, Kim IH, et al. Extremely low risk of hepatocellular carcinoma development in patients with chronic hepatitis B in immune-tolerant phase. Aliment Pharmacol Ther. 2020;52:196–204.
CAS PubMed Article Google Scholar
Lee HW, Chon YE, Kim BK, et al. Negligible HCC risk during stringently defined untreated immune-tolerant phase of chronic hepatitis B. Eur J Intern Med. 2021;84:68–73.
CAS PubMed Article Google Scholar
Kim GA, Lim YS, Han S, et al. High risk of hepatocellular carcinoma and death in patients with immune-tolerant-phase chronic hepatitis B. Gut. 2018;67:945–52.
CAS PubMed Article Google Scholar
Chu CM, Liaw YF. Prognosis of immune-tolerant-phase chronic hepatitis B. Gut. 2018;67:988.
CAS PubMed Article Google Scholar
Choi GH, Kim GA, Choi J, et al. High risk of clinical events in untreated HBeAg-negative chronic hepatitis B patients with high viral load and no significant ALT elevation. Aliment Pharmacol Ther. 2019;50:215–26.
CAS PubMed Article Google Scholar
Tseng TC, Liu CJ, Yang HC, et al. Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads. Hepatology. 2013;57:441–50.
CAS PubMed Article Google Scholar
Oliveri F, Surace L, Cavallone D, et al. Long-term outcome of inactive and active, low viraemic HBeAg-negative-hepatitis B virus infection: benign course towards HBsAg clearance. Liver Int. 2017;37:1622–31.
CAS PubMed Article Google Scholar
Bonacci M, Lens S, Mariño Z, et al. Anti-viral therapy can be delayed or avoided in a significant proportion of HBeAg-negative Caucasian patients in the Grey Zone. Aliment Pharmacol Ther. 2018;47:1397–408.
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