Afroz A, Alam K, Ali L, Karim A, Alramadan MJ, Habib SH, Magliano DJ, Billah B (2019) Type 2 diabetes mellitus in Bangladesh: a prevalence based cost-of-illness study. BMC Health Serv Res 19(1):1–12

Article  Google Scholar 

Agrawal A (2011) Pharmacological activities of flavonoids: a review. Int J Pharm Sci Nanotechnol 4(2):1394–1398

Google Scholar 

Akins NS, Mishra N, Harris HM, Dudhipala N, Kim SJ, Keasling AW, Majumdar S, Zjawiony JK, Paris JJ, Ashpole NM (2022) 6, 5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid receptor agonists as analgesics devoid of anxiogenic effects. ChemMedChem 17(7):e202100684

PubMed  Article  CAS  Google Scholar 

Alamir AH, Patil S (2021) Allicin could potentially alleviate oral cancer pain by inhibiting “pain mediators” TNF-alpha, IL-8, and endothelin. Curr Issues Mol Biol 43(1):187–196

PubMed  PubMed Central  Article  CAS  Google Scholar 

Briskin DP (2000) Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol 124(2):507–514

PubMed  PubMed Central  Article  CAS  Google Scholar 

Dubuisson D, Dennis SG (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4:161–174

PubMed  Article  CAS  Google Scholar 

Fujiwara N, Kobayashi K (2005) Macrophages in inflammation. Curr Drug Targets Inflamm Allergy 4(3):281–286

PubMed  Article  CAS  Google Scholar 

García-Mediavilla V, Crespo I, Collado PS, Esteller A, Sánchez-Campos S, Tuñón MJ, González-Gallego J (2007) The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol 557(2–3):221–229

PubMed  Article  CAS  Google Scholar 

Gawade S (2012) Acetic acid induced painful endogenous infliction in writhing test on mice. J Pharmacol Pharmacother 3(4):348

PubMed  PubMed Central  Article  Google Scholar 

Grinter SZ, Liang Y, Huang SY, Hyder SM, Zou X (2011) An inverse docking approach for identifying new potential anti-cancer targets. J Mol Graph Model 29(6):795–799

PubMed  PubMed Central  Article  CAS  Google Scholar 

Ho K-V, Efrat N, Schreiber KL, Vo PH, De Canha MN, van Staden AB, Payne BD, Oosthuizen CB, Twilley D, Lei Z (2022) Assessing anti-inflammatory activities and compounds in switchgrass (Panicum virgatum). Agriculture 12(7):936

Article  CAS  Google Scholar 

Hong Y, Abbott FV (1995) Peripheral opioid modulation of pain and inflammation in the formalin test. Eur J Pharmacol 277(1):21–28

PubMed  Article  CAS  Google Scholar 

Huang Z-H, Yin L-Q, Guan L-P, Li Z-H, Tan C (2020) Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects. Bioorg Med Chem Lett 30(11):127173

PubMed  Article  CAS  Google Scholar 

Ibrahim MAA, Abdelrahman AHM, Hassan AMA (2019) Identification of novel Plasmodium falciparum PI4KB inhibitors as potential anti-malarial drugs: homology modeling, molecular docking and molecular dynamics simulations. Comput Biol Chem 80:79–89

PubMed  Article  CAS  Google Scholar 

Iwakiri Y, Groszmann RJ (2006) The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. Hepatology 43(S1):S121–S131

PubMed  Article  CAS  Google Scholar 

Jang Y, Kim M, Hwang SW (2020) Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception. J Neuroinflammation 17(1):1–27

Article  CAS  Google Scholar 

Kassuya CAL, Cremoneze A, Barros LFL, Simas AS, da Rocha Lapa F, Mello-Silva R, Stefanello MÉA, Zampronio AR (2009) Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). J Ethnopharmacol 124(3):369–376

PubMed  Article  CAS  Google Scholar 

Kim JH, Kismali G, Gupta SC (2018) Natural products for the prevention and treatment of chronic inflammatory diseases: integrating traditional medicine into modern chronic diseases care. Hindawi 2018:1

Google Scholar 

Łyko L, Olech M, Nowak R (2022) LC-ESI-MS/MS characterization of concentrated polyphenolic fractions from rhododendron luteum and their anti-inflammatory and antioxidant activities. Molecules 27(3):827

PubMed  PubMed Central  Article  CAS  Google Scholar 

Martel-Pelletier J, Lajeunesse D, Reboul P, Pelletier J-P (2003) Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Ann Rheum Dis 62(6):501–509

PubMed  PubMed Central  Article  CAS  Google Scholar 

Martin GS (2012) Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther 10(6):701–706

PubMed  PubMed Central  Article  CAS  Google Scholar 

Ming-Tatt L, Khalivulla SI, Akhtar MN, Mohamad AS, Perimal EK, Khalid MH, Akira A, Lajis N, Israf DA, Sulaiman MR (2012) Antinociceptive activity of a synthetic curcuminoid analogue, 2, 6-bis-(4-hydroxy-3-methoxybenzylidene) cyclohexanone, on Nociception-induced models in mice. Basic Clin Pharmacol Toxicol 110(3):275–282

PubMed  Article  CAS  Google Scholar 

Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Pires MEL, Vaja R, Warner TD (2021) Cyclooxygenases and the cardiovascular system. Pharmacol Ther 217:107624

PubMed  Article  CAS  Google Scholar 

Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TPA (2007) Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 40(3):163–173

PubMed  PubMed Central  Article  Google Scholar 

Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ (2009) AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 30(16):2785–2791

PubMed  PubMed Central  Article  CAS  Google Scholar 

Parida P, Bhowmick S, Saha A, Islam MA (2021) Insight into the screening of potential beta-lactamase inhibitors as anti-bacterial chemical agents through pharmacoinformatics study. J Biomol Struct Dyn 39(3):923–942

PubMed  Article  CAS  Google Scholar 

Prasad V (2017) Notes on sedges (Cyperaceae) of andaman and nicobar islands-seven new records and five exclusions. Nelumbo Bull Bot Surv India 59(2):155–158

Google Scholar 

Pyzer-Knapp EO, Suh C, Gómez-Bombarelli R, Aguilera-Iparraguirre J, Aspuru-Guzik A (2015) What is high-throughput virtual screening? A perspective from organic materials discovery. Annu Rev Mater Res 45:195–216

Article  CAS  Google Scholar 

Quintans Júnior LJ, Guimarães AG, Santana MTD, Araújo BE, Moreira FV, Bonjardim LR, Araújo AA, Siqueira JS, Antoniolli ÂR, Botelho MA (2011) Citral reduces nociceptive and inflammatory response in rodents. Rev Bras 21(3):497–502

Google Scholar 

Reza MS, Jashimuddin M, Ahmed J, Abeer M, Naznin NE, Jafrin S, Haque ME, Barek MA, Daula ASU (2021) Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of Aeginetia indica. J Ethnopharmacol 271:113915

PubMed  Article  CAS  Google Scholar 

Roy R, Daula ASU, Akter A, Sultana S, Barek MA, Liya IJ, Basher MA (2019) Antipyretic and anti-nociceptive effects of methanol extract of leaves of Fimbristylis miliacea in mice model. J Ethnopharmacol 243:112080

PubMed  Article  CAS  Google Scholar 

Saini RK, Rengasamy KR, Mahomoodally FM, Keum Y-S (2020) Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: an update on epidemiological and mechanistic perspectives. Pharmacol Res 155:104730

PubMed  Article  CAS  Google Scholar 

Saker L, Lee K, Cannito B, Gilmore A, Campbell-Lendrum DH (2004) Globalization and infectious diseases: a review of the linkages. World Health Organ. https://apps.who.int/iris/handle/10665/68726

Serhan CN, Haeggstrom J (2010) Lipid mediators in acute inflammation and resolution: eicosanoids, PAF, resolvins, and protectins. Fundam Inflamm. https://doi.org/10.1017/CBO9781139195737.014

Article  Google Scholar 

Simpson DA, Inglis CA (2001) Cyperaceae of economic, ethnobotanical and horticultural importance: a checklist. Kew Bull. https://doi.org/10.2307/4110962

Article  Google Scholar 

Singh A, Mohanty I, Singh J, Rattan S (2020) BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release. Am J Physiol Gastrointest Liver Physiol 318(1):G23-g33

PubMed  Article  CAS  Google Scholar 

Singh A, Singh J, Rattan S (2022) Evidence for the presence and release of BDNF in the neuronal and non-neuronal structures of the internal anal sphincter. Neurogastroenterol Motil 34(4):e14099

PubMed  Article  CAS  Google Scholar 

Stevenson GW, Bilsky EJ, Negus SS (2006) Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice. J Pain 7(6):408–416

PubMed  Article  CAS  Google Scholar 

Swedberg JE, De Veer SJ, Sit KC, Reboul CF, Buckle AM, Harris JM (2011) Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network. PLoS ONE 6(4):e19302

PubMed  PubMed Central  Article  CAS  Google Scholar 

Taguchi T, Katanosaka K, Yasui M, Hayashi K, Yamashita M, Wakatsuki K, Kiyama H, Yamanaka A, Mizumura K (2015) Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. Pain 156(3):415–427

PubMed  Article  CAS