Alsalem M, Haddad M, Aldossary SA, Kalbouneh H, Altarifi A, Jaffal SM, Abbas MA, Aldaoud N, El-Salem K (2019) Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor alpha in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound. Inflammopharmacology 27:1131–1142

CAS  PubMed  Article  Google Scholar 

Bae H, Kim R, Kim Y, Lee E, KIM HJ, Jung YPJSK, Kim J (2012) Effects of Schisandra chinensis Baillon (Schizandraceae) on lipopolysaccharide induced lung inflammation in mice. J Ethnopharmacol 142:41–47

CAS  PubMed  Article  Google Scholar 

Chen YJ, Tsai KS, Chan DC, Lan KC, Chen CF, Yang RS, Liu SH (2014) Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes. J Orthop Res 32:573–580

CAS  PubMed  Article  Google Scholar 

Chen D, Shen J, Zhao W, Wang T, Han L, Hamilton JL, Im HJ (2017) Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res 5:16044

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chun JN, Cho M, So I, Jeon JH (2014) The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms. Fitoterapia 97:224–233

CAS  PubMed  Article  Google Scholar 

Crofford LJ (2013) Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther 15(Suppl 3):S2

PubMed  PubMed Central  Article  CAS  Google Scholar 

Fernandes JC, Martel-Pelletier J, Pelletier JP (2002) The role of cytokines in osteoarthritis pathophysiology. Biorheology 39:237–246

CAS  PubMed  Google Scholar 

Gong D, Geng C, Jiang L, Wang L, Yoshimura H, Zhong L (2012) Mechanisms of olive leaf extract-ameliorated rat arthritis caused by kaolin and carrageenan. Phytother Res 26:397–402

CAS  PubMed  Article  Google Scholar 

Graverand-Gastineau LEMP (2010) Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets. Curr Drug Targets 11:528–535

PubMed  Article  Google Scholar 

Guo LY, Hung TM, Bae K, Jang S, Shin EM, Chung JW, Kang SS, Kim HP, Kim YS (2009) Effects of schisandrin on transcriptional factors in lipopolysaccharide-pretreated macrophages. Arch Pharm Res 32:399–405

CAS  PubMed  Article  Google Scholar 

Jeong JW, Kim JW, Ku SK, Kim SG, Kim KY, Kim GY, Hwang HJ, Kim BW, Chung HY, Kim CM, Choi YH (2015) Essential oils purified from Schisandrae semen inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 activation and migration of human aortic smooth muscle cells. BMC Complement Altern Med 15:7

PubMed  PubMed Central  Article  Google Scholar 

Jeong JW, Kim J, Choi EO, Kwon DH, Kong GM, Choi IW, Kim BH, Kim GY, Lee KW, Kim KY, Kim SG, Choi YW, Hong SH, Park C, Choi YH (2017) Schisandrae fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats. EXCLI J 16:265–277

PubMed  PubMed Central  Google Scholar 

Jhun JY, Na HS, Shin JW, Jung KA, Seo HB, Ryu JY, Choi JW, Moon SJ, Park HJ, Oh SW, Cho ML, Min JK (2018) Notoginseng Radix and Rehmanniae Radix Preparata extract combination (YH23537) reduces pain and cartilage degeneration in rats with monosodium iodoacetate-induced Osteoarthritis. J Med Food 21:745–754

CAS  PubMed  Article  Google Scholar 

Jo HG, Lee GY, Baek CY, Song HS, Lee D (2020) Analgesic and anti-inflammatory effects of aucklandia lappa root extracts on acetic acid-induced writhing in mice and monosodium iodoacetate-induced osteoarthritis in rats. Plants 10:42

PubMed Central  Article  CAS  Google Scholar 

Kang JS, Han MH, Kim GY, Kim CM, Kim BW, Hwang HJ, Hyun Y (2014a) Nrf2-mediated HO-1 induction contributes to antioxidant capacity of a Schisandrae fructus ethanol extract in C2C12 myoblasts. Nutrients 6:5667–5678

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kang YS, Han MH, Hong SH, Park C, Hwang HJ, Kim BW, Kyoung KH, Choi YW, Kim CM, Choi YH (2014b) Anti-inflammatory effects of Schisandra chinensis (Turcz.) baill fruit through the inactivation of nuclear factor-kappaB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated murine macrophages. J Cancer Prev 19:279–287

PubMed  PubMed Central  Article  Google Scholar 

Kim JW, Ku SK, Kim KY, Kim SG, Han MH, Kim GY, Hwang HJ, Kim BW, Kim CM, Choi YH (2015) Schisandrae fructus supplementation Ameliorates Sciatic neurectomy-induced muscle atrophy in mice. Oxid Med Cell Longev 2015:872428

PubMed  PubMed Central  Google Scholar 

Kim KY, Ku SK, Lee KW, Song CH, An WG (2018) Muscle-protective effects of Schisandrae fructus extracts in old mice after chronic forced exercise. J Ethnopharmacol 212:175–187

PubMed  Article  Google Scholar 

Kwon DY, Kim DS, Yang HJ, Park S (2011) The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-gamma pathways in in vitro and in vivo studies. J Ethnopharmacol 135:455–462

CAS  PubMed  Article  Google Scholar 

Lee YM, Son E, Kim SH, Kim DS (2019) Effect of Alpinia oxyphylla extract in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model. Phytomedicine 65:153095

CAS  PubMed  Article  Google Scholar 

Liang WJ, Yang HW, Liu HN, Qian W, Chen XL (2020) HMGB1 upregulates NF-kB by inhibiting IKB-alpha and associates with diabetic retinopathy. Life Sci 241:117146

CAS  PubMed  Article  Google Scholar 

Lin EA, Liu CJ (2010) The role of ADAMTSs in arthritis. Protein Cell 1:33–47

CAS  PubMed  PubMed Central  Article  Google Scholar 

Loeser RF, Goldring SR, Scanzello CR, Goldring MB (2012) Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 64:1697–1707

PubMed  PubMed Central  Article  Google Scholar 

Lv XJ, Zhao LJ, Hao YQ, Su ZZ, Li JY, Du YW, Zhang J (2015) Schisandrin B inhibits the proliferation of human lung adenocarcinoma A549 cells by inducing cycle arrest and apoptosis. Int J Clin Exp Med 8:6926–6936

PubMed  PubMed Central  Google Scholar 

Meng P, Zhang F, Zhang Y, Wei H, Tan S, Guo X, Wang S, Yu Y (2020) ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck disease. Med Hypotheses 135:109440

CAS  PubMed  Article  Google Scholar 

Monfort J, Tardif G, Roughley P, Reboul P, Boileau C, Bishop PN, Pelletier JP, Martel-Pelletier J (2008) Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis. Osteoarthritis Cartilage 16:749–755

CAS  PubMed  Article  Google Scholar 

Moon PD, Jeong HJ, Kim HM (2012) Effects of schizandrin on the expression of thymic stromal lymphopoietin in human mast cell line HMC-1. Life Sci 91:384–388

CAS  PubMed  Article  Google Scholar 

Mulero MC, Huxford T, Ghosh G (2019) NF-kappaB, IkappaB, and IKK: integral components of immune system signaling. Adv Exp Med Biol 1172:207–226

CAS  PubMed  Article  Google Scholar 

Musumeci G, Carnazza ML, Leonardi R, Loreto C (2012) Expression of beta-defensin-4 in “an in vivo and ex vivo model” of human osteoarthritic knee meniscus. Knee Surg Sports Traumatol Arthrosc 20:216–222

PubMed  Article  Google Scholar 

Panossian A, Wikman G (2008) Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine. J Ethnopharmacol 118:183–212

PubMed  Article  Google Scholar 

Park SY, Park DJ, Kim YH, Kim Y, Kim SG, Shon KJ, Choi YW, Lee SJ (2011) Upregulation of heme oxygenase-1 via PI3K/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages. Immunol Lett 139:93–101

CAS  PubMed  Article  Google Scholar 

Park EJ, Chun JN, Kim SH, Kim CY, Lee HJ, Kim HK, Park JK, Lee SW, So I, Jeon JH (2012) Schisandrin B suppresses TGFbeta1 signaling by inhibiting Smad2/3 and MAPK pathways. Biochem Pharmacol 83:378–384

CAS  PubMed  Article  Google Scholar 

Rahmati M, Mobasheri A, Mozafari M (2016) Inflammatory mediators in osteoarthritis: a critical review of the state-of-the-art, current prospects, and future challenges. Bone 85:81–90

CAS  PubMed  Article  Google Scholar 

Richards MM, Maxwell JS, Weng L, Angelos MG, Golzarian J (2016) Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine. Phys Sportsmed 44:101–108

PubMed  PubMed Central  Article  Google Scholar 

Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM, Sokolove J (2016) Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol 12:580–592

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sellam J, Berenbaum F (2010) The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 6:625–635

CAS  PubMed  Article  Google Scholar 

Sharma VK, Mamontov E, Tyagi M (2020) Effects of NSAIDs on the nanoscopic dynamics of lipid membrane. Biochim Biophys Acta Biomembr 1862:183100

CAS  PubMed  Article  Google Scholar 

Steels E, Venkatesh R, Steels E, Vitetta G, Vitetta L (2019) A double-blind randomized placebo controlled study assessing safety, tolerabil