Novel strategy for dental caries by physiologic dentin regeneration with CPNE7 peptide

Dental caries, which affect approximately 3.5 billion people worldwide, is the most common chronic disease (Dye, 2017, Kassebaum et al., 2015, World Health Oraganization, 2017). Dental caries progression eventually causes an edentulous state with chewing disability, which severely affects quality of life (Bortoluzzi et al., 2012). Therefore, treatment for dental caries is essential to improve the life quality. Still, many are unable to receive dental care due to such reasons as dental phobia (Appukuttan et al., 2015, Enkling et al., 2006, Pohjola et al., 2016) or social inequality(Vujicic et al., 2016; Williams et al., 2021).

Dental caries is infectious disease caused by imbalance of the native oral microbiome (Caufield et al., 2005). The bacteria, such as Streptococcus mutans, colonizes the tooth surface and secrete acidic byproducts. Eventually the tooth surface become soft and brittle leading to destruction of tooth structure (Çehreli et al., 2003, Kidd et al., 1996). Due to its infectious etiology, dental caries differs from other destructive dental diseases like cervical abrasion.

We previously discovered a dental epithelium-derived protein called Copine 7 (CPNE7) based on the knowledge that epithelial–mesenchymal interaction is essential for dentin development (Lee et al., 2011). We also introduced and evaluated CPNE7-DP, a CPNE7-derived functional peptide (Bai et al., 2022, Lee et al., 2020). CPNE7-DP not only regenerated tubular tertiary dentin, but also occluded the dentinal tubule surface at the defect site, the so-called biological dentin sealing (Choung et al., 2016, Park et al., 2019). These notable capacities shed light on CPNE7-DP as an effective therapeutic agent for treating dentinal defects without infection, such as dentin hypersensitivity (Lee et al., 2020, Park et al., 2019). However, the role of CPNE7-DP in dental caries remains uninvestigated. In the present, we explored the development of in vivo dentin caries models, which were exceedingly rare despite the prevalence of dental caries. We also thoroughly evaluated the possibility of using CPNE7-DP as a potential therapeutic agent for dental caries.

留言 (0)

沒有登入
gif