Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74.
CAS PubMed Article Google Scholar
DeBerardinis RJ, Chandel NS. Fundamentals of cancer metabolism. Sci Adv. 2016;2:e1600200.
PubMed PubMed Central Article CAS Google Scholar
Cheng C, Geng F, Cheng X, Guo D. Lipid metabolism reprogramming and its potential targets in cancer. Cancer Commun (Lond). 2018;38:27.
Xiao X, Tang JJ, Peng C, et al. Cholesterol modification of smoothened is required for hedgehog signaling. Mol Cell. 2017;66:154–62.
CAS PubMed Article Google Scholar
Luo J, Yang H, Song BL. Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 2020;21:225–45.
CAS PubMed Article Google Scholar
Gong J, Lin Y, Zhang H, et al. Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells. Cell Death Dis. 2020;11:267.
CAS PubMed PubMed Central Article Google Scholar
Kim D, Wu Y, Li Q, Oh YK. Nanoparticle-mediated lipid metabolic reprogramming of T cells in tumor microenvironments for immunometabolic therapy. Nanomicro Lett. 2021;13:31.
PubMed PubMed Central Google Scholar
Maan M, Peters JM, Dutta M, Patterson AD. Lipid metabolism and lipophagy in cancer. Biochem Biophys Res Commun. 2018;504:582–9.
CAS PubMed PubMed Central Article Google Scholar
Alannan M, Fayyad-Kazan H, Trezeguet V, Merched A. Targeting lipid metabolism in liver cancer. Biochemistry. 2020;59:3951–64.
CAS PubMed Article Google Scholar
Bort A, Sanchez BG, de Miguel I, Mateos-Gomez PA, Diaz-Laviada I. Dysregulated lipid metabolism in hepatocellular carcinoma cancer stem cells. Mol Biol Rep. 2020;47:2635–47.
CAS PubMed Article Google Scholar
Rohrig F, Schulze A. The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer. 2016;16:732–49.
PubMed Article CAS Google Scholar
Koundouros N, Poulogiannis G. Reprogramming of fatty acid metabolism in cancer. Br J Cancer. 2020;122:4–22.
CAS PubMed Article Google Scholar
Ping Q, Yan R, Cheng X, et al. Cancer-associated fibroblasts: overview, progress, challenges, and directions. Cancer Gene Ther. 2021;28:984–99.
CAS PubMed Article Google Scholar
Yu W, Lei Q, Yang L, et al. Contradictory roles of lipid metabolism in immune response within the tumor microenvironment. J Hematol Oncol. 2021;14:187.
CAS PubMed PubMed Central Article Google Scholar
Hu A, Zhao XT, Tu H, et al. PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis. J Lipid Res. 2018;59:507–14.
CAS PubMed PubMed Central Article Google Scholar
Xiao J, Luo J, Hu A, et al. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. Sci China Life Sci. 2019;62:1117–35.
CAS PubMed Article Google Scholar
Prochownik EV, Wang H. The metabolic fates of pyruvate in normal and neoplastic cells. Cells. 2021;10(4):762.
CAS PubMed PubMed Central Article Google Scholar
Bose S, Ramesh V, Locasale JW. Acetate metabolism in physiology, cancer, and beyond. Trends Cell Biol. 2019;29:695–703.
CAS PubMed PubMed Central Article Google Scholar
Calhoun S, Duan L, Maki CG. Acetyl-CoA synthetases ACSS1 and ACSS2 are 4-hydroxytamoxifen responsive factors that promote survival in tamoxifen treated and estrogen deprived cells. Transl Oncol. 2022;19:101386.
PubMed PubMed Central Article CAS Google Scholar
Cheng C, Geng F, Li Z, et al. Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth. Nat Metab. 2022;4:575–88.
CAS PubMed Article Google Scholar
Jones SF, Infante JR. Molecular pathways: fatty acid synthase. Clin Cancer Res. 2015;21:5434–8.
CAS PubMed Article Google Scholar
Shimano H, Sato R. SREBP-regulated lipid metabolism: convergent physiology—divergent pathophysiology. Nat Rev Endocrinol. 2017;13:710–30.
CAS PubMed Article Google Scholar
Cheng C, Ru P, Geng F, et al. Glucose-mediated N-glycosylation of SCAP is essential for SREBP-1 activation and tumor growth. Cancer Cell. 2015;28:569–81.
CAS PubMed PubMed Central Article Google Scholar
Granchi C. ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism. Eur J Med Chem. 2018;157:1276–91.
CAS PubMed Article Google Scholar
Menendez JA, Lupu R. Fatty acid synthase (FASN) as a therapeutic target in breast cancer. Expert Opin Ther Targets. 2017;21:1001–16.
CAS PubMed Article Google Scholar
Enciu AM, Radu E, Popescu ID, Hinescu ME, Ceafalan LC. Targeting CD36 as biomarker for metastasis prognostic: how far from translation into clinical practice? Biomed Res Int. 2018;2018:7801202.
PubMed PubMed Central Article CAS Google Scholar
Go GW, Mani A. Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis. Yale J Biol Med. 2012;85:19–28.
CAS PubMed PubMed Central Google Scholar
Rogers MA, Liu J, Song BL, et al. Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): enzymes with multiple sterols as substrates and as activators. J Steroid Biochem. 2015;151:102–7.
Bovenga F, Sabba C, Moschetta A. Uncoupling nuclear receptor LXR and cholesterol metabolism in cancer. Cell Metab. 2015;21:517–26.
CAS PubMed Article Google Scholar
Phillips MC. Is ABCA1 a lipid transfer protein? J Lipid Res. 2018;59:749–63.
CAS PubMed PubMed Central Article Google Scholar
Chistiakov DA, Bobryshev YV, Orekhov AN. Macrophage-mediated cholesterol handling in atherosclerosis. J Cell Mol Med. 2016;20:17–28.
CAS PubMed Article Google Scholar
Kemmerer M, Wittig I, Richter F, Brune B, Namgaladze D. AMPK activates LXRalpha and ABCA1 expression in human macrophages. Int J Biochem Cell Biol. 2016;78:1–9.
CAS PubMed Article Google Scholar
Bougarne N, Weyers B, Desmet SJ, et al. Molecular actions of PPARalpha in lipid metabolism and inflammation. Endocr Rev. 2018;39:760–802.
Pawlak M, Lefebvre P, Staels B. Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. J Hepatol. 2015;62:720–33.
CAS PubMed Article Google Scholar
Schlaepfer IR, Joshi M. CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential. Endocrinology. 2020. https://doi.org/10.1210/endocr/bqz046.
Santos CR, Schulze A. Lipid metabolism in cancer. FEBS J. 2012;279:2610–23.
CAS PubMed Article Google Scholar
Yi M, Li J, Chen S, et al. Emerging role of lipid metabolism alterations in Cancer stem cells. J Exp Clin Cancer Res. 2018;37(1):1–18.
Fernandez LP, de Gomez CM, de Ramirez MA. Alterations of lipid metabolism in cancer: implications in prognosis and treatment. Front Oncol. 2020;10:577420.
PubMed PubMed Central Article Google Scholar
Luo X, Cheng C, Tan Z, et al. Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer. 2017;16:76.
PubMed PubMed Central Article CAS Google Scholar
Vriens K, Christen S, Parik S, et al. Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity. Nature. 2019;566:403–6.
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