Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.

PubMed  Google Scholar 

Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer. Lyon, France. 2020. https://gco.iarc.fr/today. Accessed 27 Jul 2021.

Curry H, Parkes S, Powell J, Mann J. Caring for survivors of childhood cancers: the size of the problem. Eur J Cancer. 2006;42:501–8.

CAS  Article  PubMed  Google Scholar 

Corremans R, Adão R, De Keulenaer GW, Leite-Moreira F, Brás-Silva C. Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity. Clin Exp Pharmacol Physiol. 2019;46:204–15.

CAS  Article  PubMed  Google Scholar 

Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013;65:157–70.

CAS  Article  PubMed  Google Scholar 

López-Sendón J, Álvarez-Ortega C, Zamora Auñon P, Buño Soto A, Lyon AR, Farmakis D, et al. Classification, prevalence, and outcomes of anticancer therapy-induced cardiotoxicity: the CARDIOTOX registry. Eur Heart J. 2020;41:1720–9.

Article  PubMed  Google Scholar 

Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni CA, Veglia F, et al. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation. 2015;131:1981–8.

CAS  Article  PubMed  Google Scholar 

Shah KS, Yang EH, Maisel AS, Fonarow GC. The role of biomarkers in detection of cardio-toxicity. Curr Oncol Rep. 2017;19:1–8.

Article  Google Scholar 

Frias MA, Lang U, Gerber-Wicht C, James RW. Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. Cardiovasc Res. 2010;85:118–26.

CAS  Article  PubMed  Google Scholar 

Woudberg NJ, Pedretti S, Lecour S, Schulz R, Vuilleumier N, James RW, et al. Pharmacological intervention to modulate HDL: what do we target? Front Pharmacol. 2018;8:989.

PubMed Central  Article  CAS  PubMed  Google Scholar 

Camont L, Chapman MJ, Kontush A. Biological activities of HDL subpopulations and their relevance to cardiovascular disease. Trends Mol Med. 2011;17:594–603.

CAS  Article  PubMed  Google Scholar 

Woudberg NJ, Lecour S, Goedecke JH. HDL Subclass Distribution Shifts with Increasing Central Adiposity. J Obes. 2019;2019:2107178.

PubMed Central  Article  CAS  PubMed  Google Scholar 

Brinck JW, Thomas A, Lauer E, Jornayvaz FR, Brulhart-Meynet MC, Prost JC, et al. Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. Arterioscler Thromb Vasc Biol. 2016;36:817–24.

CAS  Article  PubMed  Google Scholar 

Plana JC, Galderisi M, Barac A, Ewer MS, Ky B, Scherrer-Crosbie M, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2014;27:911–39.

Article  PubMed  Google Scholar 

Lotrionte M, Biondi-Zoccai G, Abbate A, Lanzetta G, D’Ascenzo F, Malavasi V, et al. Review and meta-analysis of incidence and clinical predictors of anthracycline cardiotoxicity. Am J Cardiol. 2013;112:1980–4.

CAS  Article  PubMed  Google Scholar 

Kibudde S, Mondo CK, Kibirige D, Walusansa V, Orem J. Anthracycline induced cardiotoxicity in adult cancer patients: a prospective cohort study from a specialized oncology treatment centre in Uganda. Afr Health Sci. 2019;19:1647–56.

PubMed Central  Article  PubMed  Google Scholar 

Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 2004;56:185–229.

CAS  Article  PubMed  Google Scholar 

Cummings J, Anderson L, Willmott N, Smyth JF. The molecular pharmacology of doxorubicin in vivo. Eur J Cancer Clin Oncol. 1991;27:532–5.

CAS  Article  Google Scholar 

Breed JG, Zimmerman AN, Dormans JA, Pinedo HM. Failure of the antioxidant vitamin E to protect against adriamycin-induced cardiotoxicity in the rabbit. Cancer Res. 1980;40:2033–8.

CAS  PubMed  Google Scholar 

Berthiaume J, Oliveira P, Fariss M, Wallace KB. Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunction. Cardiovasc Toxicol. 2005;5:257–67.

CAS  Article  PubMed  Google Scholar 

Šimůnek T, Štěrba M, Popelová O, Adamcová M, Hrdina R, Geršl V. Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacol Rep. 2009;61:154–71.

Article  PubMed  Google Scholar 

Hrdina R, Gersl V, Klimtová I, Simunek T, Machackova J, Adamcová M. Anthracycline-induced cardiotoxicity. Acta Med. 2000;43:75–82.

CAS  Google Scholar 

Mitry MA, Edwards JG. Doxorubicin induced heart failure: Phenotype and molecular mechanisms. IJC Heart Vasc. 2016;10:17–24.

Article  Google Scholar 

Moradi H, Pahl MV, Elahimehr R, Vaziri ND. Impaired antioxidant activity of high-density lipoprotein in chronic kidney disease. Transl Res. 2009;153:77–85.

CAS  Article  PubMed  Google Scholar 

Songbo M, Lang H, Xinyong C, Bin X, Ping Z, Liang S. Oxidative stress injury in doxorubicin-induced cardiotoxicity. Toxicol Lett. 2019;307:41–8.

CAS  Article  PubMed  Google Scholar 

Octavia Y, Tocchetti CG, Gabrielson KL, Janssens S, Crijns HJ, Moens AL. Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol. 2012;52:1213–25.

CAS  Article  PubMed  Google Scholar 

Odom AL, Hatwig CA, Stanley JS, Benson AM. Biochemical determinants of adriamycin® toxicity in mouse liver, heart and intestine. Biochem Pharmacol. 1992;43:831–6.

CAS  Article  PubMed  Google Scholar 

Wallace KB, Sardão VA, Oliveira PJ. Mitochondrial determinants of doxorubicin-induced cardiomyopathy. Circ Res. 2020;126:926–41.

CAS  PubMed Central  Article  PubMed  Google Scholar 

Huang J, Wu R, Chen L, Yang Z, Yan D, Li M. Understanding Anthracycline Cardiotoxicity From Mitochondrial Aspect. Front Pharmacol. 2022;13:811406–811406.

CAS  PubMed Central  Article  PubMed  Google Scholar 

Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, et al. Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem. 2009;16:3267–85.

CAS  Article  PubMed  Google Scholar 

Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature. 2008;454:455–62.

CAS  PubMed Central  Article  PubMed  Google Scholar 

Nicolay K, Timmers RJ, Spoelstra E, Van Der Neut R, Fok JJ, Huigen YM, et al. The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes. Biochim Biophys Acta Biomembr. 1984;778:359–71.

CAS  Article  Google Scholar 

Goormaghtigh E, Brasseur R, Ruysschaert J-M. Adriamycin inactivates cytochrome c oxidase by exclusion of the enzyme from its cardiolipin essential environment. Biochem Biophys Res Commun. 1982;104:314–20.

CAS  Article  PubMed  Google Scholar 

Oliveira PJ, Wallace KB. Depletion of adenine nucleotide translocator protein in heart mitochondria from doxorubicin-treated rats—relevance for mitochondrial dysfunction. Toxicology. 2006;220:160–8.

CAS  Article  PubMed  Google Scholar 

Marcillat O, Zhang Y, Davies KJ. Oxidative and non-oxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxorubicin. Biochem J. 1989;259:181–9.

CAS  PubMed Central  Article  PubMed  Google Scholar 

Pointon AV, Walker TM, Phillips KM, Luo J, Riley J, Zhang S-D, et al. Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation. PLoS ONE. 2010;5:e12733.

PubMed Central  Article  CAS  PubMed  Google Scholar 

Ichikawa Y, Ghanefar M, Bayeva M, Wu R, Khechaduri A, Prasad SVN, et al. Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J Clin Invest. 2014;124:617–30.

CAS  PubMed Central  Article  PubMed  Google Scholar 

Cascales A, Sánchez-Vega B, Navarro N, Pastor-Quirante F, Corral J, Vicente V, et al. Clinical and genetic determinants of anthracycline-induced cardiac iron accumulation. Int J Cardiol. 2012;154:282–6.

Article  PubMed  Google Scholar 

Khiati S, Dalla Rosa I, Sourbier C, Ma X, Rao VA, Neckers LM, et al. Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity. Clin Cancer Res. 2014;20:4873–81.

CAS  PubMed Central  Article  PubMed  Google Scholar