Advances in Pharmacology and Pharmacy Vol. 10(4), pp. 265 - 272
DOI: 10.13189/app.2022.100405
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T. Y. Pasha , C. Manojmouli *, B. Ramesh , K. Naga Prashant , K. N. Purushotham , Noor Ul Eain , M. Shankar
Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, India

ABSTRACT

Lung, prostate, and stomach cancer are the most prevalent cancers among males. Breast, colon, and cervical cancer are the most prevalent cancers among women. The literature also shows that patients suffering from cancer are increasing constantly, and hence the number of different chemotherapy treatments administered is increasing. The main objective of this review article is to summarize the effect of age on the half-life of some antineoplastic drugs belonging to the category of Topoisomerase inhibitors, alkylating agents, anthracyclines, purine analogs, antimetabolites, and N-nitrosoureas along with their pharmacokinetic properties. Literature indicates that highly bound antineoplastic drugs have higher differences in unbound drug concentrations among patients, and in some cases, the amount of concentration is not reflective of the unbound drug level and has an impact on pharmacokinetic parameters, including absorption, the volume of distribution, drug metabolism, and excretion. Protein binding affects the distribution and bioavailability of active drug substances.

KEYWORDS
Half-Life, Antineoplastic Agents, Pharmacokinetics, Cytochrome P450, Plasma Protein Binding

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] T. Y. Pasha , C. Manojmouli , B. Ramesh , K. Naga Prashant , K. N. Purushotham , Noor Ul Eain , M. Shankar , "Therapeutic Importance of Biological Half-Life of Antineoplastic Agents- A Review," Advances in Pharmacology and Pharmacy, Vol. 10, No. 4, pp. 265 - 272, 2022. DOI: 10.13189/app.2022.100405.

(b). APA Format:
T. Y. Pasha , C. Manojmouli , B. Ramesh , K. Naga Prashant , K. N. Purushotham , Noor Ul Eain , M. Shankar (2022). Therapeutic Importance of Biological Half-Life of Antineoplastic Agents- A Review. Advances in Pharmacology and Pharmacy, 10(4), 265 - 272. DOI: 10.13189/app.2022.100405.