* Corresponding Author; email: [email protected]

1Unit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal

3Department of Gastroenterology, São João Hospital University Centre, Porto, Portugal

4Center for Health Technology and Services Research, Porto, Portugal

5Clinical Pharmacology Unit, São João Hospital University Centre, Porto, Portugal

6Portuguese Inflammatory Bowel Disease Group, Porto, Portugal