Weight Loss Interventions and Skeletal Health in Persons with Diabetes

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Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, Garcia KR, Glasser S, Greenway FL, Gregg EW, Hazuda HP, Hergenroeder A, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Kahn SE, Knowler WC, Lewis CE, Miller M, Montez MG, Nathan DM, Patricio JL, Peters AL, Pi-Sunyer X, Pownall HJ, Reboussin D, Redmon JB, Steinberg H, Wadden TA, Wagenknecht LE, Wing RR, Womack CR, Yanovski SZ, Zhang P, Schwartz AV, Look Ahead Study Group. The effect of intentional weight loss on fracture risk in persons with diabetes: Results from the look ahead randomized clinical trial. J Bone Miner Res. 2017;32(11):2278-2287. Look AHEAD was the largest randomized controlled trial which could examine the effects of intensional weight loss on bone health. It has reported the short- and long-term effects of intensive lifesytle intervention for weight loss on bone mineral densit and fracture risk.

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