Lew, Daniel P., and Francis A. Waldvogel. 2004. Osteomyelitis. Lancet 364. Elsevier B.V. 369–379. https://doi.org/10.1016/S0140-6736(04)16727-5.

Urish, Kenneth L., and James E. Cassat. 2020. Staphylococcus aureus osteomyelitis: bone, bugs, and surgery. Infection and Immunity 88. https://doi.org/10.1128/IAI.00932-19

Ben-Zvi, Lior, Jeremy Hassan, Marah andraous, Daniel Weltsch, Diklah Sebag, Michael Margulis, and Benjamin Bernfeld. 2021. Diagnosis and management of osteomyelitis in children. Current Infectious Disease Reports 23. Springer. https://doi.org/10.1007/S11908-021-00763-0.

Gimza, Brittney D., and James E. Cassat. 2021. Mechanisms of antibiotic failure during Staphylococcus aureus osteomyelitis. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.638085.

Article  PubMed  PubMed Central  Google Scholar 

Funk, Shawn S., and Lawson A.B. Copley. 2017. Acute hematogenous osteomyelitis in children: pathogenesis, diagnosis, and treatment. Orthopedic Clinics of North America 48. Elsevier: 199–208. https://doi.org/10.1016/J.OCL.2016.12.007.

Gornitzky, Alex L., Arin E. Kim, Jennifer M. O’Donnell, and Ishaan Swarup. 2020. Diagnosis and management of osteomyelitis in children: a critical analysis review. JBJS Reviews 8. Journal of Bone and Joint Surgery Inc. https://doi.org/10.2106/JBJS.RVW.19.00202.

Peyrani, P., M. Allen, D. Seligson, C. Roberts, A. Chen, N. Haque, M. Zervos, et al. 2012. Clinical outcomes of osteomyelitis patients infected with methicillin-resistant Staphylococcus aureus USA-300 strains. American journal of orthopedics (Belle Mead, N.J.) 41: 117–122.

Arnold, Sandra R., David Elias, Steven C. Buckingham, Eddie D. Thomas, Eduardo Novais, Alexandre Arkader, and Cassandra Howard. 2006. Changing patterns of acute hematogenous osteomyelitis and septic arthritis: emergence of community-associated methicillin-resistant Staphylococcus aureus. Journal of pediatric orthopedics 26. J Pediatr Orthop: 703–708. https://doi.org/10.1097/01.BPO.0000242431.91489.B4.

Hatzenbuehler, John, and Thomas J. Pulling. 2011. Diagnosis and management of osteomyelitis. American Family Physician 84. American Academy of Family Physicians: 1027–1033. https://doi.org/10.2165/00019053-199916060-00003.

Nair, Sean, Yu Song, Sajeda Meghji, Kris Reddi, Malcolm Harris, Alistair Ross, Stephen Poole, Michael Wilson, and Brian Henderson. 1995. Surface-associated proteins from Staphylococcus aureus demonstrate potent bone resorbing activity. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 10. J Bone Miner Res: 726–734. https://doi.org/10.1002/JBMR.5650100509.

Meghji, S, S J Crean, P A Hill, M Sheikh, S P Nair, K Heron, B Henderson, E B Mawer, and M Harris. 1998. Surface-associated protein from Staphylococcus aureus stimulates osteoclastogenesis: possible role in S. aureus-induced bone pathology. British Journal of Rheumatology. Vol. 37.

Sin, Lau, Yu., Wilson Wang, Afsaneh Sabokbar, Hamish Simpson, Sean Nair, Brian Henderson, Anthony Berendt, and Nicholas A. Athanasou. 2006. Staphylococcus aureus capsular material promotes osteoclast formation. Injury 37: 41–48. https://doi.org/10.1016/J.INJURY.2006.04.008.

Article  Google Scholar 

Madrazo, Denise R., Susanne L. Tranguch, and Ian Marriott. 2003. Signaling via toll-like receptor 5 can initiate inflammatory mediator production by murine osteoblasts. Infection and immunity 71: 5418–5421.

CAS  Article  Google Scholar 

Chauhan, V.S., and I. Marriott. 2010. Differential roles for NOD2 in osteoblast inflammatory immune responses to bacterial pathogens of bone tissue. Journal of Medical Microbiology 59: 755–762. https://doi.org/10.1099/jmm.0.015859-0.

CAS  Article  PubMed  Google Scholar 

Marriott, I., D.M. Rati, S.H. McCall, and S.L. Tranguch. 2005. Induction of Nod1 and Nod2 intracellular pattern recognition receptors in murine osteoblasts following bacterial challenge. Infection and Immunity 73: 2967–2973. https://doi.org/10.1128/IAI.73.5.2967-2973.2005.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gasper, Nancy A., Cynthia C. Petty, Laura W. Schrum, Ian Marriott, and Kenneth L. Bost. 2002. Bacterium-induced CXCL10 secretion by osteoblasts can be mediated in part through toll-like receptor 4. Infection and immunity 70: 4075–4082.

CAS  Article  Google Scholar 

Barton, Gregory M., and Ruslan Medzhitov. 2003. Toll-like receptor signaling pathways. Science 300: 1524–1525. https://doi.org/10.1126/SCIENCE.1085536.

CAS  Article  PubMed  Google Scholar 

Zou, Wei, Alla Amcheslavsky, and Zvi Bar-Shavit. 2003. CpG oligodeoxynucleotides modulate the osteoclastogenic activity of osteoblasts via toll-like receptor 9. Journal of Biological Chemistry 278: 16732–16740. https://doi.org/10.1074/JBC.M212473200.

CAS  Article  PubMed  Google Scholar 

Marriott, Ian, David L. Gray, Dana M. Rati, Vance G. Fowler, Martin E. Stryjewski, L. Scott Levin, Michael C. Hudson, and Kenneth L. Bost. 2005. Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. Bone 37: 504–512. https://doi.org/10.1016/J.BONE.2005.05.011.

CAS  Article  PubMed  Google Scholar 

Marriott, Ian, David L. Gray, Susanne L. Tranguch, Vance G. Fowler, Martin Stryjewski, L. Scott Levin, Michael C. Hudson, and Kenneth L. Bost. 2004. Osteoblasts express the inflammatory cytokine interleukin-6 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. American Journal of Pathology 164. American Society for Investigative Pathology Inc.: 1399–1406. https://doi.org/10.1016/S0002-9440(10)63226-9.

Marriott, Ian, Francis M. Hughes, and Kenneth L. Bost. 2002. Bacterial infection of osteoblasts induces interleukin-1β and interleukin-18 transcription but not protein synthesis. Journal of Interferon and Cytokine Research 22: 1049–1055. https://doi.org/10.1089/107999002760624288.

CAS  Article  PubMed  Google Scholar 

Marriott, Ian. 2004. Osteoblast responses to bacterial pathogens: A previously unappreciated role for bone-forming cells in host defense and disease progression. Immunologic Research 30: 291–308. https://doi.org/10.1385/IR:30:3:291.

CAS  Article  PubMed  Google Scholar 

Liu, Da., Lei Sheng Jiang, and Li Yang Dai. 2007. Substance P and its receptors in bone metabolism. Neuropeptides. https://doi.org/10.1016/j.npep.2007.05.003.

Article  PubMed  Google Scholar 

Niedermair, Tanja, Stephan Schirner, Raphael Seebröker, Rainer H. Straub, and Susanne Grässel. 2018. Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts. Scientific Reports 8. https://doi.org/10.1038/s41598-018-27432-y

Xing, Li., Fu., Feng Xu Zi, Xiao Lin, Wu. Feng, Jia Yu Zhong, Yi. Wang, Bei Guo, Ming Hui Zheng, Su Kang Shan, and Ling Qing Yuan. 2020. The role of substance P in the regulation of bone and cartilage metabolic activity. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2020.00077.

Article  PubMed  PubMed Central  Google Scholar 

Imai, Shinji, and Yoshitaka Matsusue. 2002. Neuronal regulation of bone metabolism and anabolism: calcitonin gene-related peptide-, substance P-, and tyrosine hydroxylase-containing nerves and the bone. Microscopy Research and Technique 58. https://doi.org/10.1002/jemt.10119

Lerner, Ulf H. 2002. Neuropeptidergic regulation of bone resorption and bone formation. Journal of Musculoskeletal Neuronal Interactions 2.

Goto, Tetsuya, Takayoshi Yamaza, Mizuho A. Kido, and Teruo Tanaka. 1998. Light- and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone. Cell and Tissue Research 293. https://doi.org/10.1007/s004410051100

Grässel, Susanne. 2014. The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology. Arthritis Research and Therapy. https://doi.org/10.1186/s13075-014-0485-1.

Article  PubMed  PubMed Central  Google Scholar 

Sun, Seungyup, Nicklaus H. Diggins, Zachary J. Gunderson, Jill C. Fehrenbacher, Fletcher A. White, and Melissa A. Kacena. 2020. No pain, no gain? The effects of pain-promoting neuropeptides and neurotrophins on fracture healing. Bone 131. Elsevier Inc. https://doi.org/10.1016/J.BONE.2019.115109.

Marriott, I., and K.L. Bost. 2001. Expression of authentic substance P receptors in murine and human dendritic cells. Journal of neuroimmunology 114: 131–141.

CAS  Article  Google Scholar 

Burmeister, Amanda R., M. Brittany Johnson, Vinita S. Chauhan, Megan J. Moerdyk-Schauwecker, Ada D. Young, Ian D. Cooley, Alejandra N. Martinez, Geeta Ramesh, Mario T. Philipp, and Ian Marriott. 2017. Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P. Journal of Neuroinflammation. https://doi.org/10.1186/s12974-017-1012-5.

Article  PubMed  PubMed Central  Google Scholar 

Marriott, Ian, Michael J. Mason, Adam Elhofy, and Kenneth L. Bost. 2000. Substance P activates NF-κB independent of elevations in intracellular calcium in murine macrophages and dendritic cells. Journal of Neuroimmunology 102: 163–171. https://doi.org/10.1016/S0165-5728(99)00182-4.

CAS  Article  PubMed  Google Scholar 

Kataeva, G., A. Agro, and A.M. Stanisz. 1994. Substance-P-mediated intestinal inflammation: Inhibitory effects of CP 96,345 and SMS 201–995. NeuroImmunoModulation 1: 350–356. https://doi.org/10.1159/000097187.

CAS  Article  PubMed  Google Scholar 

Marriott, Ian, and Kenneth L. Bost. 2001. Substance P receptor mediated macrophage responses. In Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases, 493:247–254. Boston: Kluwer Academic Publishers. https://doi.org/10.1007/0-306-47611-8_30.

Rogers, Donna P., Carol R. Wyatt, Paul H. Walz, James S. Drouillard, and Derek A. Mosier. 2006. Bovine alveolar macrophage neurokinin-1 and response to substance P. Veterinary Immunology and Immunopathology 112: 290–295. https://doi.org/10.1016/J.VETIMM.2006.03.001.

CAS  Article  PubMed  Google Scholar 

Rasley, Amy, Ian Marriott, Craig R Halberstadt, Kenneth L Bost, and Juan Anguita. 2004. Substance P augments Borrelia burgdorferi-induced prostaglandin E2 production by murine microglia. Journal of immunology (Baltimore, Md. : 1950) 172: 5707–13.

Marriott, I., M.J. Mason, A. Elhofy, and K.L. Bost. 2000. Substance P activates NF-kappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells. Journal of neuroimmunology 102: 163–171.

CAS  Article  Google Scholar 

Landau, A.M., K. Yashpal, C.M. Cahill, and M. st. Louis, A. Ribeiro-da-Silva, and J. L. Henry. 2007. Sensory neuron and substance P involvement in symptoms of a zymosan-induced rat model of acute bowel inflammation. Neuroscience 145: 699–707. https://doi.org/10.1016/J.NEUROSCIENCE.2006.11.066.

CAS  Article  PubMed  Google Scholar 

Elsawa, Sherine F, William Taylor, Cynthia C Petty, Ian Marriott, Joel v Weinstock, and Kenneth L Bost. 2003. Reduced CTL response and increased viral burden in substance P receptor-deficient mice infected with murine gamma-herpesvirus 68. Journal of immunology (Baltimore, Md. : 1950) 170: 2605–12.

Wang, Liping, Rong Zhao, Xiaoyou Shi, Tzuping Wei, Bernard P. Halloran, David J. Clark, Christopher R. Jacobs, and Wade S. Kingery. 2009. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone 45: 309–320. https://doi.org/10.1016/J.BONE.2009.04.203.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Vincent, Cristina, Masakazu Kogawa, David M. Findlay, and Gerald J. Atkins. 2009. The generation of osteoclasts from RAW 264.7 precursors in defined, serum-free conditions. Journal of Bone and Mineral Metabolism 27: 114–119. https://doi.org/10.1007/S00774-008-0018-6.

CAS  Article  PubMed  Google Scholar 

Ng, Andrew Y.H., Chengjian Tu, Shichen Shen, Ding Xu, Merry J. Oursler, Jun Qu, and Shuying Yang. 2018. Comparative characterization of osteoclasts derived from murine bone marrow macrophages and RAW 264.7 cells using quantitative proteomics. JBMR Plus 2. Blackwell Publishing Ltd: 328–340. https://doi.org/10.1002/JBM4.10058.

Collin-Osdoby, Patricia, and Philip Osdoby. 2012. RANKL-mediated osteoclast formation from murine RAW 264.7 cells. Methods in Molecular Biology 816: 187–202. https://doi.org/10.1007/978-1-61779-415-5_13.

CAS  Article  PubMed  Google Scholar 

Bost, Kenneth L, Jennifer L Bento, Cynthia C Petty, Laura W Schrum, Michael C Hudson, and Ian Marriott. 2001. Monocyte chemoattractant protein-1 expression by osteoblasts following infection with Staphylococcus aureus or Salmonella. Journal of Interferon and Cytokine Research. 21. Mary Ann Liebert, Inc.

Spagnolo, N., F. Greco, A. Rossi, L. Ciolli, A. Teti, and P. Posteraro. 1993. Chronic staphylococcal osteomyelitis: A new experimental rat model. Infection and Immunity 61: 5225–5230. https://doi.org/10.1128/IAI.61.12.5225-5230.1993.

CAS  Article  PubMed  PubMed Central  Google Scholar 

Goto, Tetsuya, Takayoshi Yamaza, Mizuho A. Kido, and Teruo Tanaka. 2001. Substance P activates osteoclast formation and osteoclastic bene resorption through the neurokinin-1 receptor. Acta Histochemica et Cytochemica 34. https://doi.org/10.1267/ahc.34.31

Sohn, Soo Joon. 2005. Substance P upregulates osteoclastogenesis by activating nuclear factor kappa B in osteoclast precursors. Acta Oto-Laryngologica 125. https://doi.org/10.1080/00016480410017710

Sun, Ying Ming, Song Jiao Luo, and Yu Hui Zhao. 2006. Substance P regulates function of osteoclasts via neurokinin-1 receptor. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 24.

Eiji Fukuhara Tetsuya Goto Takaaki Matayoshi Shigeru Kobayashi Tetsu Takahashi 2005 Substance P stimulates the formation of osteoclasts from human peripheral blood monocytes The Journal of the Kyushu Dental Society 59 https://doi.org/10.2504/kds.59.53

Matayoshi, Takaaki, Tetsuya Goto, Eiji Fukuhara, Hiroshi Takano, Shigeru Kobayashi, and Tetsu Takahashi. 2005. Neuropeptide substance P stimulates the formation of osteoclasts via synovial fibroblastic cells. Biochemical and Biophysical Research Communications 327. https://doi.org/10.1016/j.bbrc.2004.12.05

Krause, J. E., D. A. DiMaggio, and K. E. McCarson. 1995. Alterations in neurokinin 1 receptor gene expression in models of pain and inflammation. Canadian Journal of Physiology and Pharmacology 73. Canadian Science Publishing: 854–859. https://doi.org/10.1139/Y95-117.

Liu, J.Y., J.H. Hu, Q.G. Zhu, F.Q. Li, and H.J. Sun. 2006. Substance P receptor expression in human skin keratinocytes and fibroblasts. British Journal of Dermatology 155: 657–662. https://doi.org/10.1111/J.1365-2133.2006.07408.X.

CAS  Article  PubMed  Google Scholar 

Bae, Sang Jae, Yoshitaka Matsunaga, Motoi Takenaka, Yoichi Tanaka, Yoichiro Hamazaki, Kazuhiro Shimizu, and Ichiro Katayama. 2002. Substance P induced preprotachykinin-A mRNA, neutral endopeptidase mRNA and substance P in cultured normal fibroblasts. International Archives of Allergy and Immunology 127: 316–321. https://doi.org/10.1159/000057749.

CAS  Article  PubMed  Google Scholar 

Heffner, Mollie A., Damian C. Genetos, and Blaine A. Christiansen. 2017. Bone adaptation to mechanical loading in a mouse model of reduced peripheral sensory nerve function. PLoS ONE 12. Public Library of Science. https://doi.org/10.1371/JOURNAL.PONE.0187354.

Sun, Hai Biao, Jun Chang Chen, Qiang Liu, Min Feng Guo, and Hua Ping Zhang. 2010. Substance P stimulates differentiation of mice osteoblast through up-regulating Osterix expression. Chinese Journal of Traumatology - English Edition 13. Elsevier B.V.: 46–50. https://doi.org/10.3760/CMA.J.ISSN.1008-1275.2010.01.009.