Rigel DS, Carucci JA. Malignant melanoma: prevention, early detection, and treatment in the 21st century. CA Cancer J Clin. 2000;50:215–36 quiz 237–40.

CAS  PubMed  Article  Google Scholar 

Perera E, Gnaneswaran N, Jennens R, Sinclair R. Malignant Melanoma. Healthcare (Basel). 2013;2:1–19.

Article  Google Scholar 

Larkin J, Hodi FS, Wolchok JD. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015;373:1270–1.

PubMed  Article  CAS  Google Scholar 

Horvat TZ, Adel NG, Dang T-O, Momtaz P, Postow MA, Callahan MK, et al. Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial Sloan Kettering cancer center. J Clin Oncol. 2015;33:3193–8.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Slominski AT, Carlson JA. Melanoma resistance: a bright future for academicians and a challenge for patient advocates. Mayo Clin Proc. 2014;89:429–33.

PubMed  Article  Google Scholar 

Soriano P, Montgomery C, Geske R, Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell. 1991;64:693–702.

CAS  PubMed  Article  Google Scholar 

Vara JÁF, Cáceres MAD, Silva A, Martı́n-Pérez J. Src family kinases are required for prolactin induction of cell proliferation. Mol Biol Cell. 2001;12:2171–83.

CAS  PubMed Central  Article  Google Scholar 

Kim LC, Song L, Haura EB. Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol. 2009;6:587–95.

PubMed  Article  CAS  Google Scholar 

Okada M. Regulation of the SRC family kinases by Csk. Int J Biol Sci. 2012;8:1385–97.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhao M, Finlay D, Zharkikh I, Vuori K. Novel role of Src in priming Pyk2 phosphorylation. PLoS One. 2016;11:e0149231.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Berdeaux RL, Díaz B, Kim L, Martin GS. Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function. J Cell Biol. 2004;166:317–23.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene. 2000;19:5636–42.

CAS  PubMed  Article  Google Scholar 

Qi J, Wang J, Romanyuk O, Siu C-H. Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells. Mol Biol Cell. 2006;17:1261–72.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Eustace AJ, Crown J, Clynes M, O’Donovan N. Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines. J Transl Med. 2008;6:53.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Oneyama C, Hikita T, Nada S, Okada M. Functional dissection of transformation by c-Src and v-Src. Genes Cells. 2008;13:1–12.

CAS  PubMed  Article  Google Scholar 

Homsi J, Cubitt CL, Zhang S, Munster PN, Yu H, Sullivan DM, et al. Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma. Melanoma Res. 2009;19:167–75.

CAS  PubMed  Article  Google Scholar 

Sánchez-Bailón MP, Calcabrini A, Gómez-Domínguez D, Morte B, Martín-Forero E, Gómez-López G, et al. Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells. Cell Signal. 2012;24:1276–86.

PubMed  Article  CAS  Google Scholar 

Andrä K, Lassmann H, Bittner R, Shorny S, Fässler R, Propst F, et al. Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture. Genes Dev. 1997;11:3143–56.

PubMed  PubMed Central  Article  Google Scholar 

Steinböck FA, Wiche G. Plectin: a cytolinker by design. Biol Chem. 1999;380:151–8.

PubMed  Article  Google Scholar 

Osmanagic-Myers S, Gregor M, Walko G, Burgstaller G, Reipert S, Wiche G. Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration. J Cell Biol. 2006;174:557–68.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Matsubara T, Kinbara M, Maeda T, Yoshizawa M, Kokabu S, Takano YT. Regulation of osteoclast differentiation and actin ring formation by the cytolinker protein plectin. Biochem Biophys Res Commun. 2017;489:472–6.

CAS  PubMed  Article  Google Scholar 

Matsubara T, Yaginuma T, Addison WN, Fujita Y, Watanabe K, Yoshioka I, et al. Plectin stabilizes microtubules during osteoclastic bone resorption by acting as a scaffold for Src and Pyk2. Bone. 2020;132:115209.

CAS  PubMed  Article  Google Scholar 

Bausch D, Thomas S, Mino-Kenudson M, Fernández-del CC, Bauer TW, Williams M, et al. Plectin-1 as a novel biomarker for pancreatic cancer. Clin Cancer Res. 2011;17:302–9.

CAS  PubMed  Article  Google Scholar 

Katada K, Tomonaga T, Satoh M, Matsushita K, Tonoike Y, Kodera Y, et al. Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma. J Proteomics. 2012;75:1803–15.

CAS  PubMed  Article  Google Scholar 

Tamura I, Ueda K, Nishikawa T, Kamada A, Okamura T, Matsuda Y, et al. Expression of Plectin-1 and Trichohyalin in human tongue Cancer cells. OJST. 2018;08:196–204.

CAS  Article  Google Scholar 

Meier SM, Kreutz D, Winter L, Klose MHM, Cseh K, Weiss T, et al. An organoruthenium anticancer agent shows unexpected target selectivity for plectin. Angew Chem Int Ed Engl. 2017;56:8267–71.

CAS  PubMed  Article  Google Scholar 

Klose MHM, Schöberl A, Heffeter P, Berger W, Hartinger CG, Koellensperger G, et al. Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC-ICP-MS. Monatsh Chem. 2018;149:1719–26.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ogawa M, Yaginuma T, Nakatomi C, Nakajima T, Tada-Shigeyama Y, Addison WN, et al. Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity. Oncotarget. 2019;10:404–14.

PubMed  PubMed Central  Article  Google Scholar 

Katoh K. Regulation of fibroblast cell polarity by Src tyrosine kinase. Biomedicines. 2021;9:135.

Kirihara Y, Takechi M, Kurosaki K, Kobayashi Y, Kurosawa T. Anesthetic effects of a mixture of medetomidine, midazolam and butorphanol in two strains of mice. Exp Anim. 2013;62:173–80.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Nakanishi M, Hata K, Nagayama T, Sakurai T, Nishisho T, Wakabayashi H, et al. Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: a potential mechanism of inflammatory pain. Mol Biol Cell. 2010;21:2568–77.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tada Y, Kokabu S, Sugiyama G, Nakatomi C, Aoki K, Fukushima H, et al. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014;5:12317–30.

PubMed  PubMed Central  Article  Google Scholar 

Liu Y, Qi X, Li G, Sowa G. Caveolin-2 deficiency induces a rapid anti-tumor immune response prior to regression of implanted murine lung carcinoma tumors. Sci Rep. 2019;9:18970.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rojasawasthien T, Shirakawa T, Washio A, Tsujisawa T, Matsubara T, Inoue A, et al. Vignacyanidin polyphenols isolated from Vigna Angularis bean promote osteoblast differentiation. In Vivo. 2021;35:883–8.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Miyawaki A, Rojasawasthien T, Hitomi S, Aoki Y, Urata M, Inoue A, et al. Oral administration of Geranylgeraniol rescues denervation-induced muscle atrophy via suppression of Atrogin-1. In Vivo. 2020;34:2345–51.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shirakawa T, Miyawaki A, Matsubara T, Okumura N, Okamoto H, Nakai N, et al. Daily oral administration of protease-treated royal jelly protects against denervation-induced skeletal muscle atrophy. Nutrients. 2020;12:3089.

Nath S, Devi GR. Three-dimensional culture systems in cancer research: focus on tumor spheroid model. Pharmacol Ther. 2016;163:94–108.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rötzer V, Breit A, Waschke J, Spindler V. Adducin is required for desmosomal cohesion in keratinocytes. J Biol Chem. 2014;289:14925–40.

PubMed  PubMed Central  Article  CAS  Google Scholar