Predictive value of SLCO1B1 c.521T>C polymorphism on observed changes in the treatment of 1136 statin-users

Abstract

Purpose Pharmacogenomic testing is a method to prevent adverse drug reactions. Pharmacogenomics could be relevant to optimize statin treatment, by identifying patients at high risk for adverse drug reactions. We aim to investigate the clinical validity and utility of pre-emptive pharmacogenomics screening in primary care, with SLCO1B1 c.521T>C as a risk factor for statin induced adverse drug reactions. Methods The focus was on changes in therapy as a proxy for adverse drug reactions observed in statin-users in a population-based Dutch cohort. In total 1136 statin users were retrospectively genotyped for the SLCO1B1 c.521T>C polymorphism (rs4149056) and information on their statin dispensing was evaluated as a cross-sectional research. Results Approximately half of the included participants discontinued or switched their statin treatment within three years. In our analyses we could not confirm an association between the SLCO1B1 c.521T>C genotype and any change in statin therapy or arriving at a stable dose sooner in primary care. Conclusion To be able to evaluate the predictive values of SLCO1B1 c.521T>C genotype on adverse drug reactions from statins, prospective data collection of actual adverse drug reactions and reasons to change statin treatment should be facilitated.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

The research was supported by the National Institute for Public Health and the Environment (RIVM) in the strategic programme (SPR), project number S132001 Personalised Medicine.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

This research was evaluated by the Medical Ethical Committee of the VU University Medical Center Amsterdam (identifier 2017.074) and the Compliance Committee of the PHARMO Institute.

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Data Availability

All data produced in the present study are available upon reasonable request to the authors

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