Relationship of preoperative oral hypofunction with prognostic nutritional index in gastric cancer

Abstract

We recruited patients with perioperative gastric cancer and examined preoperative oral hypofunction and its relationship with prognostic nutritional index. This cross-sectional study analysed 95 patients who underwent oral function management. We assessed the following parameters: body mass index, stage of gastric cancer, C-reactive protein, total lymphocyte count, albumin, and prognostic nutritional index. The patients were divided into two groups: prognostic nutritional index <45 and prognostic nutritional index >45. Logistic regression analysis was used to assess the association between the measurements of oral function and the prognostic nutritional index.A univariate analysis of factors associated with decreased oral function and prognostic nutritional index showed significant differences in C-reactive protein, neutrophils and tongue pressure (p<0.01) between the two groups. However, oral hygiene, oral dryness, occlusal force, tongue-lip motor function, masticatory function, and swallowing function were not significantly different. Multivariate analysis showed that C-reactive protein (odds ratio: 0.12, 95% confidence interval: 0.30–0.45, p<0.01) and tongue pressure (odds ratio: 3.62, 95% confidence interval: 1.04–12.60, p<0.05) were independent risk factors for oral hypofunction. Oral function is decreased in perioperative patients with gastric cancer, and decreased tongue pressure is associated with decreased prognostic nutritional index.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

The authors received no specific funding for this work.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

This research was independently reviewed and approved by the Ethics Committee of the Nagoya Ekisaikai Hospital (approval number 2021-048). The study was performed in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines and the principles of the Declaration of Helsinki. The experiments were undertaken with the understanding and written consent of each subject and according to the above mentioned principles.

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

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Data Availability

All data generated or analysed during this study are included in this published article.

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