Mendez-Armenta M, Nava-Ruiz C, Juarez-Rebollar D, Rodriguez-Martinez E, Gomez PY (2014) Oxidative stress associated with neuronal apoptosis in experimental models of epilepsy. Oxid Med Cell Longev 2014:293689

PubMed  PubMed Central  Article  Google Scholar 

Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR (2010) Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia 51:883–890

PubMed  PubMed Central  Article  Google Scholar 

Avoli M et al (2002) Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. Prog Neurobiol 68:167–207

CAS  PubMed  Article  Google Scholar 

Aminoff MJ, Simon RP (1980) Status epilepticus: causes, clinical features and consequences in 98 patients. Am J Med 69(5):657–666

CAS  PubMed  Article  Google Scholar 

Trinka E, Hofler J, Leitinger M, Brigo F (2015) Pharmacotherapy for status epilepticus. Drugs 75:1499–1521

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, Engel J Jr (2005) Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 46:470–472

PubMed  Article  Google Scholar 

Si PP, Zhen JL, Cai YL, Wang WJ, Wang WP (2016) Salidroside protects against kainic acid-induced status epilepticus via suppressing oxidative stress. Neurosci Lett 618:19–24

CAS  PubMed  Article  Google Scholar 

Costa AM, Lucchi C, Malkoç A, Rustichelli C, Biagini G (2021) Relationship between delta rhythm, seizure occurrence and allopregnanolone hippocampal levels in epileptic rats exposed to the rebound effect. Pharmaceuticals 14(2):127

CAS  PubMed  PubMed Central  Article  Google Scholar 

Devinsky O, Vezzani A, Najjar S, De Lanerolle NC, Rogawski MA (2013) Glia and epilepsy: excitability and inflammation. Trends Neurosci 36:174–184

CAS  PubMed  Article  Google Scholar 

Frantseva MV, Perez Velazquez JL, Tsoraklidis G (2000) Oxidative stress is involved in seizure–induced neurodegeneration in the kindling model of epilepsy. Neuroscience 97:431–435

CAS  PubMed  Article  Google Scholar 

Gluck MR, Jayatilleke E, Shaw S, Rowan AJ, Haroutunian V (2000) CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy. Epilepsy Res 39:63–71

CAS  PubMed  Article  Google Scholar 

Patsokis N, Zervoudakis G, Panagopoulos NT (2004) Thiol redox state (TRS) and oxidative stres in the mouse hippocampus after pentylenetetrazol-induced epileptic seizure. Neurosci Lett 357:83–86

Article  CAS  Google Scholar 

Patsokis NG, Zervoudakis C, Georgiou D (2004) Effect of pentylenetetrazol-induced epileptic seizure on thiol redox state in the mouse cerebral cortex. Epilepsy Res 62:65–74

Article  CAS  Google Scholar 

Atmaca M, Fry JR (1996) Adenosine-mediated inhibition of glutathione synthesis in rat isolated hepatocytes. Biochem Pharmocol 52:1423–1428

CAS  Article  Google Scholar 

Sudha K, Rao AV, Rao A (2001) Oxidative stress and antioxidants in epilepsy. Clin Chim Acta 303:19–24

CAS  PubMed  Article  Google Scholar 

Oliver CN, Starke-Reed PE, Stadtman ER, Lin GJ, Correy JM, Floyd RA (1990) Oxidative damage to brain proteins, loss of glutamine synthetase activity and production of free radicals during ischemia/reperfusion induced injury to gerbil brain. Proc Natl Acad Sci USA 87:5144–5147

CAS  PubMed  PubMed Central  Article  Google Scholar 

Koshal P, Kumar P (2016) Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice. Mol Cell Biochem 415(1–2):77–87

CAS  PubMed  Article  Google Scholar 

Knauf C, Cani PD, Kim D-H, Iglesias MA, Chabo C, Waget A et al (2008) Role of central nervous system glucagon-like peptide-1 receptors in enteric glucose sensing. Diabetes 57:2603–2612

CAS  PubMed  PubMed Central  Article  Google Scholar 

Yoshino Y, Ishisaka M, Tsujii S, Shimazawa M, Hara H (2015) Glucagon-like peptide-1 protects the murine hippocampus against stressors via Akt and ERK1/2 signaling. Biochem Biophys Res Commun 458:274–279

CAS  PubMed  Article  Google Scholar 

During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X et al (2003) Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 9:1173–1179

CAS  PubMed  Article  Google Scholar 

Harkavyi A, Whitton PS (2010) Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection. Br J Pharmacol 159:495–501

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ladenheim EE (2015) Liraglutide and obesity: a review of the data so far. Drug Des Devel Ther 9:1867

CAS  PubMed  PubMed Central  Article  Google Scholar 

Hansen HH, Fabricius K, Barkholt P, Niehoff ML, Morley JE, Jelsing J et al (2015) The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer’s disease. J Alzheimers Dis 46(4):877–888

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kim DI, Park SH (2015) Glucagon peptide-like 1 receptor (GLP-1R) expression per se: a new insight into neurodegenerative disease? Neural Regen Res 10(7):1055

CAS  PubMed  PubMed Central  Article  Google Scholar 

Holscher C (2014) The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer’s disease. Alzheimers Dement 10:S47-54

PubMed  Google Scholar 

Darsalia V, Mansouri S, Ortsater H, Olverling A, Nozadze N, Kappe C, Iverfeldt K, Tracy LM, Grankvist N, Sjoholm A, Patrone C (2012) Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats. Clin Sci (Lond) 122:473–483

CAS  Article  Google Scholar 

Faivre E, Hölscher C (2013) Neuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse model. Alzheimers Res Ther 5:20

CAS  PubMed  PubMed Central  Article  Google Scholar 

Solmaz V, Çınar BP, Yiğittürk G, Çavuşoğlu T, Taşkıran D, Erbaş O (2015) Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats. Eur J Pharmacol 765:482–487

CAS  PubMed  Article  Google Scholar 

Aksoy D, Solmaz V, Çavuşoğlu T, Meral A, Ateş U, Erbaş O (2017) Neuroprotective effects of eexenatide in a rotenone-induced rat model of Parkinson’s disease. Am J Med Sci 354(3):319–324

PubMed  Article  Google Scholar 

Erdogan MA, Yusuf D, Christy J, Solmaz V, Erdogan A, Taskiran E, Erbas O (2018) Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy. BMC Neurol 18(1):1–8

Article  CAS  Google Scholar 

Erdogan A, Erdogan MA, Atasoy O et al (2021) Effects of the calcium channel blocker otilonium bromide on seizure activity in rats with pentylenetetrazole-induced convulsions. Neurochem Res 46:1717–1724. https://doi.org/10.1007/s11064-021-03310-4

CAS  Article  PubMed  Google Scholar 

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1–2):248–254

CAS  PubMed  Article  Google Scholar 

Genkova-Papazova M, Petkova B, Shishkova N, Lazarova-Bakarova M (2000) The GABA-B antagonist CGP 36742 prevent PTZ-kindling-provoked amnesia in rats. Eur Neuropsychopharmacol 10:273–278

CAS  PubMed  Article  Google Scholar 

Agarwal NB, Agarwal NK, Mediratta PK, Sharma KK (2011) Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice. Seizure 20:257–262

PubMed  Article  Google Scholar 

Gupta Y, Kumar MV, Srivastava A (2003) Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats. Pharmacol Biochem Behav 74:579–585

CAS  PubMed  Article  Google Scholar 

Mehla J, Reeta K, Gupta P, Gupta YK (2010) Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci 87:596–603

CAS  PubMed  Article  Google Scholar 

Dhir A, Naidu PS, Kulkarni SK (2007) Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. Seizure 16:691–697

PubMed  Article  Google Scholar 

Sehar N, Agarwal NB, Vohora D, Raisuddin S (2015) Atorvastatin prevents development of kindling by modulating hippocampal levels of dopamine, glutamate, and GABA in mice. Epilepsy Behav 42:48–53

PubMed  Article