Obesity: a perfect storm for carcinogenesis

Ward, Z. J. et al. (2019) Projected U.S. State-level prevalence of adult obesity and severe obesity. New England Journal of Medicine, 381, 2440–2450.

Smittenaar, C. R., Petersen, K. A., Stewart, K., & Moitt, N. (2016). Cancer incidence and mortality projections in the UK until 2035. British Journal of Cancer, 115, 1147–1155.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Cancer Intelligence Team. When could overweight and obesity overtake smoking as the biggest cause of cancer in the UK? Cancer Research UK (2018). Available online at: https://www.cancerresearchuk.org/sites/default/files/obesity_tobacco_cross_over_report_final.pdf Accessed: 12/9/21

Steele, C. B., et al. (2017). Vital signs: Trends in incidence of cancers associated with overweight and obesity — United States, 2005–2014. MMWR Morb Mortal Wkly Rep, 66, 1052–1058.

PubMed  PubMed Central  Article  Google Scholar 

Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. The New England Journal of Medicine, 348, 1625–1638.

PubMed  Article  Google Scholar 

Lauby-Secretan, B., et al. (2016). Body fatness and cancer — Viewpoint of the IARC working group. New England Journal of Medicine, 375, 794–798.

PubMed  Article  Google Scholar 

Schauer, D. P., et al. (2019). Bariatric surgery and the risk of cancer in a large multisite cohort. Annals of Surgery, 269, 95–101.

PubMed  Article  Google Scholar 

Pearson-Stuttard, J., et al. (2018). Worldwide burden of cancer attributable to diabetes and high body-mass index: A comparative risk assessment. The Lancet Diabetes and Endocrinology, 6, e6–e15.

PubMed  Article  Google Scholar 

Petrelli, F., et al. (2021). Association of obesity with survival outcomes in patients with cancer: A systematic review and meta-analysis. JAMA Network Open, 4, e213520–e213520.

PubMed  PubMed Central  Article  Google Scholar 

Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: The next generation. Cell, 144, 646–674.

CAS  PubMed  Article  Google Scholar 

Gregor, M. F., & Hotamisligil, G. S. (2011). Inflammatory mechanisms in obesity. Annual Review of Immunology, 29, 415–445.

CAS  PubMed  Article  Google Scholar 

Kishida, K., et al. (2011). Relationships between circulating adiponectin levels and fat distribution in obese subjects. Journal of Atherosclerosis and Thrombosis, 18, 592–595.

CAS  PubMed  Article  Google Scholar 

Lönnqvist, F., et al. (1997). Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. The Journal of Clinical Investigation, 99, 2398–2404.

PubMed  PubMed Central  Article  Google Scholar 

Silha, J. V. & Murphy, L. J. (2004) Serum resistin (FIZZ3) protein is increased in obese humans. The Journal of Clinical Endocrinology and Metabolism, 89, 1977–1978.

Asghari, A., & Umetani, M. (2020). Obesity and cancer: 27-hydroxycholesterol, the missing link. International Journal of Molecular Sciences, 21, 4822.

CAS  PubMed Central  Article  Google Scholar 

Hashimoto, N., & Hara, H. (2003). Dietary amino acids promote pancreatic protease synthesis at the translation stage in rats. Journal of Nutrition, 133, 3052–3057.

CAS  PubMed  Article  Google Scholar 

Ni, Y., et al. (2015). Circulating unsaturated fatty acids delineate the metabolic status of obese individuals. eBioMedicine, 2, 1513–1522.

PubMed  PubMed Central  Article  Google Scholar 

John, H. J. (1927). The relationship of obesity to carbohydrate metabolism. The American Journal of the Medical Sciences, 173, 184–194.

Article  Google Scholar 

Favennec, M., et al. (2015). The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. Obesity, 23, 2066–2074.

CAS  PubMed  Article  Google Scholar 

Filippatos, T. D., et al. (2017). Effects of increased body weight and short-term weight loss on serum PCSK9 levels – A prospective pilot study. Archives of Medical Science - Atherosclerotic Diseases, 2, 46–51.

Article  Google Scholar 

Yoshimoto, S., et al. (2013). Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature, 499, 97–101.

CAS  PubMed  Article  Google Scholar 

Karbownik-Lewinska, M., et al. (2012). Direct contribution of obesity to oxidative damage to macromolecules. Neuro Endocrinology Letters, 33, 453–461.

CAS  PubMed  Google Scholar 

Bankoglu, E. E., et al. (2016). Impact of weight loss induced by gastric bypass or caloric restriction on oxidative stress and genomic damage in obese Zucker rats. Free Radical Biology and Medicine, 94, 208–217.

CAS  PubMed  Article  Google Scholar 

Lassenius, M. I., et al. (2011). Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation. Diabetes Care, 34, 1809–1815.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lee, E., et al. (2014). Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Nature Communications, 5, 4715.

CAS  PubMed  Article  Google Scholar 

Laurent, V., et al. (2016). Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity. Nature Communications, 7, 10230.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Schmidt, F. M., et al. (2015). Inflammatory cytokines in general and central obesity and modulating effects of physical activity. PLoS ONE, 10, e0121971.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Moschen, A. R., et al. (2011). Adipose and liver expression of interleukin (IL)-1 family members in morbid obesity and effects of weight loss. Molecular Medicine, 17, 840–845.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Vendrell, J., et al. (2004). Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: Relationships in obesity. Obesity Research, 12, 962–971.

CAS  PubMed  Article  Google Scholar 

Straczkowski, M., et al. (2002). Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-α system. The Journal of Clinical Endocrinology & Metabolism, 87, 4602–4606.

CAS  Article  Google Scholar 

Blüher, M., et al. (2005). Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism. Experimental and Clinical Endocrinology & Diabetes, 113, 534–537.

Article  CAS  Google Scholar 

Ahmad, R., Thomas, R., Kochumon, S., & Sindhu, S. (2017). Increased adipose tissue expression of IL-18R and its ligand IL-18 associates with inflammation and insulin resistance in obesity. Immun Inflamm Dis, 5, 318–335.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Catalán, V., et al. (2007). Proinflammatory cytokines in obesity: Impact of type 2 diabetes mellitus and gastric bypass. Obesity Surgery, 17, 1464–1474.

PubMed  Article  Google Scholar 

Olszanecka-Glinianowicz, M., Zahorska-Markiewicz, B., Janowska, J., & Zurakowski, A. (2004). Serum concentrations of nitric oxide, tumor necrosis factor (TNF)-alpha and TNF soluble receptors in women with overweight and obesity. Metabolism, 53, 1268–1273.

CAS  PubMed  Article  Google Scholar 

Yadav, H., et al. (2011). Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metabolism, 14, 67–79.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lynch, L., et al. (2009). Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity. European Journal of Immunology, 39, 1893–1901.

CAS  PubMed  Article  Google Scholar 

Frasca, D., et al. (2016). Obesity decreases B cell responses in young and elderly individuals. Obesity, 24, 615.

CAS  PubMed  Article  Google Scholar 

Nishimura, S., et al. (2009). CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nature Medicine, 15, 914–920.

CAS  PubMed  Article  Google Scholar 

Wu, D., et al. (2011). Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science, 332, 243–247.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Toubal, A., et al. (2020). Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity. Nature Communications, 11, 1–20.

Article  CAS  Google Scholar 

Bao, Y., Mo, J., Ruan, L., & Li, G. (2015). Increased monocytic CD14+HLADRlow/- myeloid-derived suppressor cells in obesity. Molecular Medicine Reports, 11, 2322–2328.

CAS  PubMed  Article  Google Scholar 

Tiwari, P., et al. (2019). Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. Journal of Experimental Medicine, 216, 1345–1358.

CAS  PubMed  PubMed Central  Article 

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