Jibrel Abdulkadir Emam Estifanos Ele Yaya Muhammad Iqbal Choudhary Sammer Yousuf Tetemke Mehari Gebremedihn

Keywords: Polygonaceae, Rumex abyssinicu Jacq., Cytotoxic, Antifungal, Anti-Inflammatory, Reactive oxygen species

Abstract

 

ABSTRACT. Rumex abyssinicus showed strong cytotoxicity against HeLa cells (IC50 = 22.25 μg/mL) and weak cytotoxicity against PC3 and BJ cells with percent inhibition of 58.6, 25.8 and 29.7% at 30.0 μg/mL. It showed moderate antifungal activity against Aspergillus niger with a percent growth inhibition of 55.5% at 3000 µg/mL. It also strongly inhibited oxidative burst with IC50 value of 24.8 μg/mL. DCM (100%) and DCM: EtOAc (1:1) fractions showed strong cytotoxicity against HeLa cells, whilst pet ether: DCM (1:1) fraction showed strong cytotoxicity against PC3 cells with IC50 values of 29.3, 26.3 and 24.3 μg/mL, respectively. Moreover, the DCM: EtOAc (1:1) fraction inhibited ROS production with IC50 value of 18.8 μg/mL. Cytotoxic fractions afforded chrysophanol (1), physicon (2), emodin (3), citreorosein (4) and β-sitosterol (5). Among the isolated compounds, emodin (3) showed strong cytotoxicity against HeLa cells, whilst chrysphanol (1) and physicon (2) showed strong cytotoxicity against PC3 cells with IC50 values of 8.94, 22.5, and 28.5 µM, respectively. In addition, emodin (3) and citreorosein (4) showed strong inhibition against ROS production with an IC50 value of 16.2 and 38.2 μg/mL. The findings of this study suggest R. abyssinicus as a good candidate for cancer and inflammation management.  

 

KEY WORDS: Polygonaceae, Rumex abyssinicu Jacq., Cytotoxic, Antifungal, Anti-Inflammatory, Reactive oxygen species

 

Bull. Chem. Soc. Ethiop. 2022, 36(4), 879-892.                                                              

DOI: https://dx.doi.org/10.4314/bcse.v36i4.13