Ogurtsova K, da Rocha Fernandes JD, Huang Y, et al. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40–50.

CAS  PubMed  Article  Google Scholar 

World Health Organisation. WHO Global Health Observatory Data Repository 2020. https://apps.who.int/gho/data/view.main. Accessed 1 Feb 2022.

Health and Social Care Information Centre. Statistics on obesity, physical activity and diet, England. NHS Digital. 2019. https://digital.nhs.uk/data-and-information/publications/statistical/statistics-on-obesity-physical-activity-and-diet/statistics-on-obesity-physical-activity-and-diet-england-2019/part-3-adult-obesity. Accessed 1 Feb 2022.

Ward ZJ, Bleich SN, Cradock AL, et al. Projected US state-level prevalence of adult obesity and severe obesity. N Engl J Med. 2019;381(25):2440–50.

PubMed  Article  Google Scholar 

Feldman EL, Callaghan BC, Pop-Busui R, et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019;5(1):42.

PubMed Central  Article  Google Scholar 

Pop-Busui R, Herman WH, Feldman EL, et al. DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history. Curr Diab Rep. 2010;10(4):276–82.

PubMed  PubMed Central  Article  Google Scholar 

Tesfaye S, Selvarajah D. The Eurodiab study: what has this taught us about diabetic peripheral neuropathy? Curr Diab Rep. 2009;9(6):432–4.

PubMed  Article  Google Scholar 

Andersen ST, Witte DR, Dalsgaard EM, et al. Risk factors for incident diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes followed for 13 years: ADDITION-Denmark. Diabetes Care. 2018;41(5):1068–75.

CAS  PubMed  Article  Google Scholar 

Ziegler D, Rathmann W, Dickhaus T, Meisinger C, Mielck A. Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg surveys S2 and S3. Diabetes Care. 2008;31(3):464–9.

CAS  PubMed  Article  Google Scholar 

Hanewinckel R, Drenthen J, Ligthart S, et al. Metabolic syndrome is related to polyneuropathy and impaired peripheral nerve function: a prospective population-based cohort study. J Neurol Neurosurg Psychiatry. 2016;87(12):1336–42.

PubMed  Article  Google Scholar 

Callaghan BC, Xia R, Banerjee M, et al. Metabolic syndrome components are associated with symptomatic polyneuropathy independent of glycemic status. Diabetes Care. 2016;39(5):801–7.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ziegler D, Rathmann W, Dickhaus T, Meisinger C, Mielck A. Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg surveys S2 and S3. Diabetes Care. 2008;31(3):464–9.

CAS  PubMed  Article  Google Scholar 

Viader A, Sasaki Y, Kim S, et al. Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy. Neuron. 2013;77(5):886–98.

CAS  PubMed  PubMed Central  Article  Google Scholar 

National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979;28(12):1039–57.

Dyck PJ, Albers JW, Andersen H, et al. Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity. Diabetes Metab Res Rev. 2011;27(7):620–8.

PubMed  Article  Google Scholar 

Lee JA, Halpern EM, Lovblom LE, Yeung E, Bril V, Perkins BA. Reliability and validity of a point-of-care sural nerve conduction device for identification of diabetic neuropathy. PLoS ONE. 2014;9(1): e86515.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Tesfaye S, Chaturvedi N, Eaton SE, et al. Vascular risk factors and diabetic neuropathy. N Engl J Med. 2005;352(4):341–50.

CAS  PubMed  Article  Google Scholar 

Smith AG, Singleton JR. Obesity and hyperlipidemia are risk factors for early diabetic neuropathy. J Diabetes Complications. 2013;27(5):436–42.

PubMed  PubMed Central  Article  Google Scholar 

Azmi S, Ferdousi M, Liu Y, et al. The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity. Sci Rep. 2021;11(1):12573.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Buckman LB, Hasty AH, Flaherty DK, et al. Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system. Brain Behav Immun. 2014;35:33–42.

CAS  PubMed  Article  Google Scholar 

Guillemot-Legris O, Masquelier J, Everard A, Cani PD, Alhouayek M, Muccioli GG. High-fat diet feeding differentially affects the development of inflammation in the central nervous system. J Neuroinflammation. 2016;13(1):206.

PubMed  PubMed Central  Article  CAS  Google Scholar 

O’Brien PD, Hinder LM, Callaghan BC, Feldman EL. Neurological consequences of obesity. Lancet Neurol. 2017;16(6):465–77.

PubMed  PubMed Central  Article  Google Scholar 

Ziegler D, Rathmann W, Dickhaus T, Meisinger C, Mielck A. Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy. Diabetes Care. 2008;31(3):464.

CAS  PubMed  Article  Google Scholar 

Dziewas R, Schilling M, Engel P, et al. Treatment for obstructive sleep apnoea: effect on peripheral nerve function. J Neurol Neurosurg Psychiatry. 2007;78(3):295–7.

PubMed  Article  Google Scholar 

Fidan-Yaylali G, Yaylali YT, Erdogan Ç, et al. The association between central adiposity and autonomic dysfunction in obesity. Med Princ Pract. 2016;25(5):442–8.

PubMed  PubMed Central  Article  Google Scholar 

Guarino D, Nannipieri M, Iervasi G, Taddei S, Bruno RM. The role of the autonomic nervous system in the pathophysiology of obesity. Front Physiol. 2017;8:665.

PubMed  PubMed Central  Article  Google Scholar 

Xu L, Zeng H, Zhao J, et al. Index of plantar pressure alters with prolonged diabetes duration. Diabetes Ther. 2019;10(6):2139–52.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Gao S, Zhang H, Long C, Xing Z. Association between obesity and microvascular diseases in patients with type 2 diabetes mellitus. Front Endocrinol (Lausanne). 2021;12(1307).

Callaghan BC, Reynolds E, Banerjee M, Chant E, Villegas-Umana E, Feldman EL. Central obesity is associated with neuropathy in the severely obese. Mayo Clin Proc. 2020;95(7):1342–53.

PubMed  Article  Google Scholar 

Herman RM, Brower JB, Stoddard DG, et al. Prevalence of somatic small fiber neuropathy in obesity. Int J Obes (Lond). 2007;31(2):226–35.

CAS  Article  Google Scholar 

Miscio G, Guastamacchia G, Brunani A, Priano L, Baudo S, Mauro A. Obesity and peripheral neuropathy risk: a dangerous liaison. J Peripher Nerv Syst. 2005;10(4):354–8.

PubMed  Article  Google Scholar 

Ylitalo KR, Sowers M, Heeringa S. Peripheral vascular disease and peripheral neuropathy in individuals with cardiometabolic clustering and obesity. Diabetes Care. 2011;34(7):1642.

PubMed  PubMed Central  Article  Google Scholar 

Roustit M, Loader J, Deusenbery C, Baltzis D, Veves A. Endothelial dysfunction as a link between cardiovascular risk factors and peripheral neuropathy in diabetes. J Clin Endocrinol Metab. 2016;101(9):3401–8.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Spallone V, Morganti R, D’Amato C, et al. Clinical correlates of painful diabetic neuropathy and relationship of neuropathic pain with sensorimotor and autonomic nerve function. Eur J Pain. 2011;15(2):153–60.

PubMed  Article  Google Scholar 

Schlesinger S, Herder C, Kannenberg JM, et al. General and abdominal obesity and incident distal sensorimotor polyneuropathy: insights into inflammatory biomarkers as potential mediators in the KORA F4/FF4 cohort. Diabetes Care. 2019;42(2):240.

CAS  PubMed  Article  Google Scholar 

Puchalska P, Crawford PA. Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Cell Metab. 2017;25(2):262–84.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bruce KD, Zsombok A, Eckel RH. Lipid processing in the brain: a key regulator of systemic metabolism. Front Endocrinol. 2017;8:60.

Article  Google Scholar 

Coccurello R, Nazio F, Rossi C, et al. Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice. PLoS ONE. 2018;13(12):e0208596.

PubMed  PubMed Central  Article  Google Scholar 

Rumora AE, LoGrasso G, Hayes JM, et al. The divergent roles of dietary saturated and monounsaturated fatty acids on nerve function in murine models of obesity. J Neurosci. 2019;39(19):3770–81.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Iqbal Z, Kalteniece A, Ferdousi M, et al. Corneal keratocyte density and corneal nerves are reduced in patients with severe obesity and improve after bariatric surgery. Investig Ophthalmol Vis Sci. 2021;62(1):20.

CAS  Article  Google Scholar 

Adam S, Azmi S, Ho JH, et al. Improvements in diabetic neuropathy and nephropathy after bariatric surgery: a prospective cohort study. Obes Surg. 2021;31(2):554–63.

PubMed  Article  Google Scholar 

Verheijen MH, Chrast R, Burrola P, Lemke G. Local regulation of fat metabolism in peripheral nerves. Genes Dev. 2003;17(19):2450–64.

CAS  PubMed  PubMed Central