Small-animal blood exchange is an emerging approach for systemic aging research

Villeda, S. A. et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90–96 (2011).

CAS  Article  Google Scholar 

Villeda, S. A. et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat. Med. 20, 659–663 (2014).

CAS  Article  Google Scholar 

Loffredo, F. S. et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 153, 828–839 (2013).

CAS  Article  Google Scholar 

Conboy, I. M. et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433, 760–764 (2005).

CAS  Article  Google Scholar 

Conboy, I. M. & Rando, T. A. Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches. Cell Cycle 11, 2260–2267 (2012).

CAS  Article  Google Scholar 

Conboy, M. J., Conboy, I. M. & Rando, T. A. Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging Cell. 12, 525–530 (2013).

CAS  Article  Google Scholar 

Elabd, C. et al. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nat. Commun. 5, 4082 (2014).

CAS  Article  Google Scholar 

Yousef, H. et al. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nat. Med. 25, 988–1000 (2019).

CAS  Article  Google Scholar 

Yousef, H. et al. Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal. Oncotarget 6, 11959–11978 (2015).

Article  Google Scholar 

Castellano, J. M. et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature 544, 488–492 (2017).

CAS  Article  Google Scholar 

Yousef, H. et al. Age-associated increase in BMP signaling inhibits hippocampal neurogenesis. Stem Cells 33, 1577–1588 (2015).

CAS  Article  Google Scholar 

Yousef, H. et al. hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding. Aging 5, 357–372 (2013).

CAS  Article  Google Scholar 

Carlson, M. E. et al. Relative roles of TGF- β1 and Wnt in the systemic regulation and aging of satellite cell responses. Aging Cell 8, 676–689 (2009).

CAS  Article  Google Scholar 

Carlson, M. E., Silva, H. S. & Conboy, I. M. Aging of signal transduction pathways, and pathology. Exp. Cell Res. 314, 1951–1961 (2008).

CAS  Article  Google Scholar 

Egerman, M. A. et al. GDF11 Increases with age and inhibits skeletal muscle regeneration. Cell Metab. 22, 164–174 (2015).

CAS  Article  Google Scholar 

Smith, L. K. et al. β2-Microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat. Med. 21, 932–937 (2015).

CAS  Article  Google Scholar 

Conboy, I. M., Conboy, M. J. & Rebo, J. Systemic problems: a perspective on stem cell aging and rejuvenation. Aging 7, 754–765 (2015).

CAS  Article  Google Scholar 

Schaffer, D. V. & Gage, F. H. Neurogenesis and neuroadaptation. Neuromol. Med. 5, 1–9 (2004).

CAS  Article  Google Scholar 

Bruel-Jungerman, E., Laroche, S. & Rampon, C. New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur. J. Neurosci. 21, 513–521 (2005).

Article  Google Scholar 

Mehdipour, M. et al. Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline–albumin. Aging 12, 8790–8819 (2020).

CAS  Article  Google Scholar 

Mehdipour, M. et al. Plasma dilution improves cognition and attenuates neuroinflammation in old mice. Geroscience https://doi.org/10.1007/s11357-020-00297-8 (2020).

Rebo, J. et al. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nat. Commun. 7, 13363 (2016).

CAS  Article  Google Scholar 

Esser, F., Masselter, T. & Speck, T. Silent pumpers: a comparative topical overview of the peristaltic pumping principle in living nature, engineering, and biomimetics. Adv. Intell. Syst. 1, 1900009 (2019).

Article  Google Scholar 

Horobin, J. T., Sabapathy, S. & Simmonds, M. J. Repetitive supra-physiological shear stress impairs red blood cell deformability and induces hemolysis. Artif. Organs 41, 1017–1025 (2017).

Article  Google Scholar 

Zhang, T. et al. Study of flow-induced hemolysis using novel couette-type blood-shearing devices. Artif. Organs 35, 1180–1186 (2011).

Article  Google Scholar 

Finerty, J. C. & Panos, T. C. Parabiosis intoxication. Proc. Soc. Exp. Biol. Med. 76, 833–835 (1951).

CAS  Article  Google Scholar 

Finerty, J. C. Parabiosis in physiological studies. Physiol. Rev. 32, 277–302 (1952).

CAS  Article  Google Scholar 

Horowitz, A. M. et al. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. Science 369, 167–173 (2020).

CAS  Article  Google Scholar 

De Miguel, Z. et al. Exercise plasma boosts memory and dampens brain inflammation via clusterin. Nature (2021) https://doi.org/10.1038/s41586-021-04183-x

Zhang, G., Budker, V. & Wolff, J. A. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum. Gene Ther. 10, 1735–1737 (1999).

CAS  Article  Google Scholar 

McKeen, L. W. Introduction to fatigue of plastics and elastomers. Fatigue and Tribological Properties of Plastics and Elastomers 3rd edn (Elsevier, 2016); https://doi.org/10.1016/B978-0-323-44201-5.00001-0

McKeen, L. W. Introduction to the tribology of plastics and elastomers. Fatigue and Tribological Properties of Plastics and Elastomers 3rd edn (Elsevier, 2016); https://doi.org/10.1016/B978-0-323-44201-5.00002-2

Ventola, C. L. Medical applications for 3D printing: current and projected uses. P&T 39, 704–711 (2014).

Google Scholar 

Mastellos, D. C., Reis, E. S., Ricklin, D., Smith, R. J. & Lambris, J. D. Complement C3-targeted therapy: replacing long-held assertions with evidence-based discovery. Trends Immunol. 38, 383–394 (2017).

CAS  Article  Google Scholar 

Ricklin, D., Hajishengallis, G., Yang, K. & Lambris, J. D. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11, 785–797 (2010).

CAS  Article  Google Scholar 

Kolev, M., Le Friec, G. & Kemper, C. Complement—tapping into new sites and effector systems. Nat. Rev. Immunol. 14, 811–820 (2014).

CAS  Article  Google Scholar 

Hajishengallis, G. & Lambris, J. D. Microbial manipulation of receptor crosstalk in innate immunity. Nat. Rev. Immunol. 11, 187–200 (2011).

CAS  Article  Google Scholar 

Cardoso, A. L. et al. Towards frailty biomarkers: candidates from genes and pathways regulated in aging and age-related diseases. Ageing Res. Rev. 47, 214–277 (2018).

CAS  Article  Google Scholar 

Niyonzima, N. et al. Complement activation by cholesterol crystals triggers a subsequent cytokine response. Mol. Immunol. 84, 43–50 (2017).

CAS  Article  Google Scholar 

Björk, I. & Lindahl, U. Mechanism of the anticoagulant action of heparin. Mol. Cell. Biochem. 48, 161–182 (1982).

Article  Google Scholar 

Chuang, Y.-J., Swanson, R., Raja, S. M. & Olson, S. T. Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence: evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin. J. Biol. Chem. 276, 14961–14971 (2001).

CAS  Article  Google Scholar 

Weitz, J. I. New anticoagulants for treatment of venous thromboembolism. Circulation 110, I-19–I-26 (2004).

Google Scholar 

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