Protein Loss in Peritoneal Effluent: Different Meaning for 24-h versus PET Samples

Peritoneal Dialysis – Research Article

Malho Guedes A.a,b,c· Calças Marques R.a· Domingos A.T.a· Laranjo C.a· Silva A.P.a,b· Rodrigues A.c,d,e

Author affiliations

aServiço de Nefrologia, Centro Hospitalar Universitário do Algarve, Porto, Portugal
bAlgarve Biomedical Center, Faro, Portugal
cICBAS – School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal
dServiço de Nefrologia, Centro Hospitalar Universitário do Porto, Porto, Portugal
eUMIB – Unit for Multidisciplinary Research in Biomedicine, Porto, Portugal

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Article / Publication Details

First-Page Preview

Abstract of Peritoneal Dialysis – Research Article

Received: December 23, 2021
Accepted: June 05, 2022
Published online: August 29, 2022

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 3

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU

Abstract

Introduction: Quantification of peritoneal protein loss (PPL) may be expressed according to a timely collection (24-h measurement or 4-h PET assessment) and as a concentration. The aim of this study was to compare the quantification methods of 24-h and 4-h collections. Methods: This study included 81 prevalent peritoneal dialysis patients. Demographics and clinical and bioelectrical impedance features were registered. PPL was measured (4-h PET and 24-h results) and peritoneal protein clearance was calculated. A linear regression model was performed. Results: Age and continuous ambulatory peritoneal dialysis (compared to cycler) were positively associated with greater PPL on 24-h collections. Neither cardiovascular disease, hypertension, diabetes nor the comorbidity Charlson Index was significantly associated with PPL. There was a consistent univariable relationship with D/P creatinine, whichever sampling method was used. Only 24-h measurements of PPL correlated with body composition variables. In multiple linear regression analysis, D/P creatinine association with PPL stands out. On the other hand, 24-h determinations (in grams or clearance) were associated with overhydration. PET protein quantification was associated with peritoneal creatinine clearance. Discussion/Conclusion: Different methods sign different pathophysiological pathways. PET protein loss quantification should be regarded as a marker of peritoneal membrane intrinsic permeability. Measurements of a 24-h sample might be closer to patients’ clinical status and prognosis, signalizing opportunities for therapy intervention.

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First-Page Preview

Abstract of Peritoneal Dialysis – Research Article

Received: December 23, 2021
Accepted: June 05, 2022
Published online: August 29, 2022

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 3

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU

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